US4414198A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Rapidly disintegrable tablet composition and method
Assignee: Individual
•
Filing: 1982-04-23
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Granted: 1983-11-08
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Expires: 2002-04-23
Abstract
Abstract Rapidly water-disintegrable tablet is provided comprising an active ingredient such as a foodstuff or medicament, and distributed therewithin a small but effective amount of a tablet disintegrable system comprising an unreacted, intimate mixture of alginic acid and a water soluble metal carbonate in proportions reactive to form metal alginic acid salt and carbonic acid when the tablet is placed in water, the bulk of the salt acting to swell the tablet and the carbonic acid acting to simultaneously release carbon dioxide within the swelling tablet whereby rapid disintegration of the tablet is effected.
Inventors
- 👤 Joseph Michaelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 18:15
CPC Classifications
A; A23; A23C; A23C9/00; A23C9/18; A23F; A23F5/00; A23F5/24; A23F5/36; A23F5/38; A23F5/385; A61; A61K; A61K9/00; A61K9/0002; A61K9/0007
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
99 words
Rapidly water-disintegrable tablet comprising an active ingredient, and distributed therewithin a small but effective amount of a tablet disintegrable system comprising an unreacted, intimate mixture of alginic acid and a water soluble carbonate radical precursor in proportions reactive to form metal alginic acid salt and carbonic acid when the tablet is placed in water, the bulk of said formed salt acting to swell the tablet and the carbonic acid acting to simultaneously release carbon dioxide within the swelling tablet whereby rapid disintegration of the tablet is effected, the alginic acid salt acting to body the resulting active ingredient solution.
Claim 2
Dependent Claim
99 words
Rapidly water-disintegrable tablet comprising an active ingredient, and distributed therewithin a small but effective amount of a tablet disintegrable system comprising an unreacted, intimate mixture of alginic acid and a water soluble carbonate radical precursor in proportions reactive to form metal alginic acid salt and carbonic acid when the tablet is placed in water, the bulk of said formed salt acting to swell the tablet and the carbonic acid acting to simultaneously release carbon dioxide within the swelling tablet whereby rapid disintegration of the tablet is effected, the alginic acid salt acting to body the resulting active ingredient solution.
Claim 3
Dependent Claim
16 words
The rapidly water-disintegrable tablet according to claim 1, in which said active ingredient is a medicament.
Claim 4
Dependent Claim
16 words
The rapidly water-disintegrable tablet according to claim 1 in which said active ingredient is a foodstuff.
Claim 5
Dependent Claim
26 words
The rapidly water-disintegrable tablet according to claim 1, in which the weight ratio of said carbonate radical precursor to said alginic acid is three or more.
Claim 6
Dependent Claim
32 words
The rapidly water-disintegrable tablet according to claim 4, in which said alginic acid is present in an effective amount between 0.05 and 25% by weight based on the weight of said tablet.
Claim 7
Dependent Claim
25 words
Rapidly water-disintegrable tablet according to claim 1, in which said carbonate radical precursor is a carbonate or bicarbonate of an alkali or alkaline earth metal.
Claim 8
Dependent Claim
18 words
Rapidly water-disintegrable tablet according to claim 6, in which said metal is sodium, potassium, calcium, magensium or managnese.
Claim 9
Dependent Claim
20 words
Rapidly water-disintegrable tablet according to claim 1, in which the tablet further comprises a tablet-lubricating effective amount of a lubricant.
Claim 10
Dependent Claim
18 words
Rapidly water-disintegrable tablet according to claim 8, in which the tablet lubricant comprises leucine in tablet-lubricating effective amount.
Claim 11
Dependent Claim
15 words
Rapidly water-disintegrable tablet according to claim 9, in which the leucine is L-leucine or L-isoleucine.
Claim 12
Dependent Claim
117 words
Rapidly water-disintegrable tablet comprising an active ingredient, and distributed therewithin an effective amount of a tablet disintegrable system comprising an unreacted, intimate mixture of alginic acid and a water soluble metal carbonate in proportions reactive to form metal alginic acid salt and carbonic acid when the tablet is placed in water, said alginic acid comprising from 3 to 15% and the metal carbonate from 1 to 70% of the tablet by weight, the bulk of the salt formed acting to swell the tablet and the carbonic acid acting to simultaneously release carbon dioxide within the swelling tablet whereby rapid disintegration of the tablet is effected, said alginic acid salt acting to body the resulting active ingredient solution.
Claim 13
Dependent Claim
117 words
Rapidly water-disintegrable tablet comprising an active ingredient, and distributed therewithin an effective amount of a tablet disintegrable system comprising an unreacted, intimate mixture of alginic acid and a water soluble metal carbonate in proportions reactive to form metal alginic acid salt and carbonic acid when the tablet is placed in water, said alginic acid comprising from 3 to 15% and the metal carbonate from 1 to 70% of the tablet by weight, the bulk of the salt formed acting to swell the tablet and the carbonic acid acting to simultaneously release carbon dioxide within the swelling tablet whereby rapid disintegration of the tablet is effected, said alginic acid salt acting to body the resulting active ingredient solution.
Claim 14
Dependent Claim
21 words
Rapidly water-disintegrable tablet according to claim 11, in which the metal carbonate is a carbonate or bicarbonate of an alkali metal.
Claim 15
Dependent Claim
15 words
Rapidly water-disintegrable tablet according to claim 12, in which the metal is sodium or potassium.
Claim 16
Dependent Claim
17 words
Rapidly water-disintegrable tablet according to claim 11, in which the active ingredient is a foodstuff or medicament.
Claim 17
Dependent Claim
20 words
Rapidly water-disintegrable tablet according to claim 14, in which said tablet further comprises a tablet-lubricating effective amount of a lubricant.
Claim 18
Dependent Claim
32 words
Rapidly water-disintegrable tablet according to claim 15, in which said tablet lubricant comprises L-leucine or L-isoleucine in an amount between 0.3 and 1.5 parts per 10 parts by weight of said tablet.
Claim 19
Dependent Claim
27 words
Rapidly water-disintegrable tablet according to claim 14, in which the carbonate is sodium bicarbonate and is present in about stoichiometric amount for reaction with said alginic acid.
Claim 20
Dependent Claim
48 words
Method of preparing a rapidly water-disintegrable tablet, including combining an active ingredient with a small but effective amount of an unreacted mixture of a water soluble metal carbonate and alginic acid, intimately and under pressure, pulverizing, and tabletting with a lubricant as necessary to form a stable tablet.
Claim 21
Dependent Claim
48 words
Method of preparing a rapidly water-disintegrable tablet, including combining an active ingredient with a small but effective amount of an unreacted mixture of a water soluble metal carbonate and alginic acid, intimately and under pressure, pulverizing, and tabletting with a lubricant as necessary to form a stable tablet.
Claim 22
Dependent Claim
24 words
Method according to claim 18, including also incorporating L-leucine or L-isoleucine as said lubricant, in lubricating effective amount in advance of the tabletting step.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-07 | 1987-05-09 | 1987-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-07 | 1991-05-09 | 1991-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-07 | 1995-05-09 | 1995-11-08 | $7700.00 | Window Closed / Lapsed |