US4413233A
Expired / Lapsed
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Dynamic NMR measurement
Assignee: Harvard University
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Filing: 1981-07-02
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Granted: 1983-11-01
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Expires: 2001-07-02
Abstract
Abstract Apparatus and method for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, the apparatus including an NMR pulse spectrometer capable of providing an observation pulse for instantaneously measuring the spectrum of the chemical entity in the tissue, sensing means for sensing the physical characteristic and providing an output signal, and triggering means responsive to the sensing means output signal and connected to the spectrometer for triggering the spectrometer to produce the observation pulse at a selected point in the course of the fluctuation of the physical characteristic of the tissue.
Inventors
- 👤 Eric T. Fossel
- 👤 Joanne S. Ingwall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:44
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/05; A61B5/055; G; G01; G01R; G01R33/00; G01R33/20; G01R33/28; G01R33/30; G01R33/44; G01R33/46; G01R33/465
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
95 words
Apparatus for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, comprising an NMR pulse spectrometer capable of providing an observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue, sensing means for sensing said physical characteristic and providing an output signal, and triggering means responsive to said sensing means output signal and connected to said spectrometer for triggering said spectrometer to produce said observation pulse at a selected point in the course of said fluctuation of said physical characteristic of said tissue.
Claim 2
Dependent Claim
95 words
Apparatus for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, comprising an NMR pulse spectrometer capable of providing an observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue, sensing means for sensing said physical characteristic and providing an output signal, and triggering means responsive to said sensing means output signal and connected to said spectrometer for triggering said spectrometer to produce said observation pulse at a selected point in the course of said fluctuation of said physical characteristic of said tissue.
Claim 3
Dependent Claim
91 words
Apparatus for dynamically measuring a chemical entity in living biological tissue having a cyclical physical characteristic, comprising an NMR pulse spectrometer capable of providing an observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue, sensing means for sensing said cyclical physical characteristic and providing an output signal, and triggering means responsive to said sensing means output signal and connected to said spectrometer for triggering said spectrometer to produce said observation pulse at a selected point in the cycle of said physical characteristic of said tissue.
Claim 4
Dependent Claim
91 words
Apparatus for dynamically measuring a chemical entity in living biological tissue having a cyclical physical characteristic, comprising an NMR pulse spectrometer capable of providing an observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue, sensing means for sensing said cyclical physical characteristic and providing an output signal, and triggering means responsive to said sensing means output signal and connected to said spectrometer for triggering said spectrometer to produce said observation pulse at a selected point in the cycle of said physical characteristic of said tissue.
Claim 5
Dependent Claim
42 words
Apparatus as claimed in claim 1 or 2, wherein said triggering means further inlcudes time delay means for triggering said NMR pulse spectrometer to produce said observation pulse after a predetermined time delay following the receipt of said sensing means output signal.
Claim 6
Dependent Claim
39 words
Apparatus as claimed in claim 2, wherein said triggering means further includes multiple pulse means for triggering said NMR pulse spectrometer to produce a plurality of said observation pulses within said cycle of said physical characteristic of said tissue.
Claim 7
Independent Claim
68 words
A method for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, comprising sensing said physical characteristic, and providing an NMR pulse spectrometer observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue at a selected point in the course of said fluctuation, said pulse being provided in response to said sensing of said physical characteristic.
Claim 8
Independent Claim
68 words
A method for dynamically measuring a chemical entity in living biological tissue having a physical characteristic capable of fluctuation, comprising sensing said physical characteristic, and providing an NMR pulse spectrometer observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue at a selected point in the course of said fluctuation, said pulse being provided in response to said sensing of said physical characteristic.
Claim 9
Independent Claim
69 words
A method for dynamically measuring a chemical entity in living biological tissue having a cyclical physical characteristic, comprising sensing said cyclical physical characteristic, and providing an NMR pulse spectrometer observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue at a selected point in the cycle of said cyclical physical characteristic, said pulse being provided in response to said sensing of said physical characteristic.
Claim 10
Independent Claim
69 words
A method for dynamically measuring a chemical entity in living biological tissue having a cyclical physical characteristic, comprising sensing said cyclical physical characteristic, and providing an NMR pulse spectrometer observation pulse for instantaneously measuring the spectrum of said chemical entity in said biological tissue at a selected point in the cycle of said cyclical physical characteristic, said pulse being provided in response to said sensing of said physical characteristic.
Claim 11
Dependent Claim
24 words
A method as claimed in claim 5 or claim 6, further comprising the step of providing said observation pulse after a predetermined time delay.
Claim 12
Dependent Claim
29 words
A method as claimed in claim 6, further comprising the step of providing a plurality of said observation pulses within said cycle of said physical characteristic of said tissue.
Claim 13
Dependent Claim
15 words
A method as claimed in claim 6 or 8 wherein said tissue is a heart.
Claim 14
Dependent Claim
17 words
A method as claimed in claim 9 wherein said cyclical physical characteristic is change in blood pressure.
References Cited (Backward Citations)
US3911905A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1986-10-31 | 1987-05-02 | 1987-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-31 | 1991-05-02 | 1991-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-31 | 1995-05-02 | 1995-11-01 | $7700.00 | Window Closed / Lapsed |