US4413012A
Expired / Lapsed
US
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Method for treating depression
Assignee: Merrell Toraude et Cie
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Filing: 1982-05-26
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Granted: 1983-11-01
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Expires: 2002-05-26
Abstract
Abstract 2-Amino-3-(3'-hydroxyphenyl)-3-butenoic acid or 2-amino-3-(3', 4'-dihydroxyphenyl)-3-butenoic acid can be used to treat depression either alone or in combination with an extracerebrally acting AADC inhibitor.
Inventors
- 👤 Michael G. Palfreyman
- 👤 Ian A. McDonald
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 12:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; C; C07; C07D; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
90 words
A method for treating depression which comprises administering to a depressed patient an antidepressant effective amount of 2-amino-3-(3'-hydroxyphenyl)-3-butenoic acid or 2-amino-3-(3',4'-dimethoxyphenyl)-3-butenoic acid, or a (C 1 -C 8 ) alkyl ester thereof or a pharmaceutically acceptable salt thereof; in combination with an AADC inhibitor selected from carbidopa, benserazide, or a 2-amino-3-(monofluoromethyl or difluoromethyl)-3-(monohydroxyphenyl or dihydroxyphenyl)-propionic acid, the amount of said AADC inhibitor being effective to substantially block the AADC catalyzed decarboxylation of said antidepressant compound extracerebrally without substantially blocking the AADC catalyzed decarboxylation of said antidepressant compound in the brain.
Claim 2
Independent Claim
90 words
A method for treating depression which comprises administering to a depressed patient an antidepressant effective amount of 2-amino-3-(3'-hydroxyphenyl)-3-butenoic acid or 2-amino-3-(3',4'-dimethoxyphenyl)-3-butenoic acid, or a (C 1 -C 8 ) alkyl ester thereof or a pharmaceutically acceptable salt thereof; in combination with an AADC inhibitor selected from carbidopa, benserazide, or a 2-amino-3-(monofluoromethyl or difluoromethyl)-3-(monohydroxyphenyl or dihydroxyphenyl)-propionic acid, the amount of said AADC inhibitor being effective to substantially block the AADC catalyzed decarboxylation of said antidepressant compound extracerebrally without substantially blocking the AADC catalyzed decarboxylation of said antidepressant compound in the brain.
Claim 3
Dependent Claim
14 words
A method as defined in claim 1 wherein the compound administered is 2-amino-3-(3'-hydroxyphenyl)-3-butenoic acid.
Claim 4
Dependent Claim
14 words
A method as defined in claim 1 wherein the compound administered is 2-amino-3-(3',4'-dihydroxyphenyl)-3-butenoic acid.
Claim 5
Dependent Claim
13 words
A method as defined in claim 1 wherein the AADC inhibitor is carbidopa.
Claim 6
Dependent Claim
13 words
A method as defined in claim 1 wherein the AADC inhibitor is benserazide.
Claim 7
Dependent Claim
19 words
A method as defined in claim 1 wherein the AADC inhibitor is a 2-amino-2-(monofluoromethyl or difluoromethyl)-3-(monohydroxyphenyl or dihydroxyphenyl)propionic acid.
Claim 8
Dependent Claim
24 words
A method as defined in claim 6 wherein the AADC inhibitor is 2-amino-2-fluoromethyl-3-(3',4'-dihydroxyphenyl)propionic acid or 2-amino-2-difluoromethyl-3-(3',4'-dihydroxyphenyl)propionic acid, or a 2',3'- or 2',5'-dihydroxyphenyl isomer thereof.
Claim 9
Dependent Claim
18 words
A method as claimed in claim 4, 5, 6, or 7 wherein the compound administered is 2-amino-3-(3'-hydroxyphenyl)-3-butenoic acid.
Claim 10
Dependent Claim
18 words
A method as defined in claim 4, 5, 6, or 7 wherein the compound administered is 2-amino-3-(3',4'-dihydroxyphenyl)-3-butenoic acid.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-31 | 1987-05-02 | 1987-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-31 | 1991-05-02 | 1991-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-31 | 1995-05-02 | 1995-11-01 | $7700.00 | Window Closed / Lapsed |