Patent US5473702A successfully refreshed from Google Patents.
US4412985A
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Depyrogenation process
Assignee: New York Blood Center
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Filing: 1982-01-04
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Granted: 1983-11-01
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Expires: 2002-01-04
Abstract
Abstract Products and materials used in the biomedical field are depyrogenated by prolonged contact with a solution or suspension of about 0.1% to about 10% by weight of a nonionic amphiphile selected from the group consisting of substances having the general formula RC 6 H 4 (OC 2 H 4 ) n OH wherein R is octyl or nonyl and n is at least 3, followed by liquid phase separation of said amphiphile from the resulting depyrogenated product or material.
Inventors
- 👤 Edward Shanbrom
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:28
CPC Classifications
A; A61; A61L; A61L2/00; A61L2/16; A61L2/18; A61K; A61K35/00; A61K35/12; A61K35/14; A61K39/00; A61L2103/00; A61L2103/05
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
85 words
The method of depyrogenating a biomedical product or material comprising treating said product or material by prolonged contact with a solution or suspension of about 0.1% to about 10% by weight of a nonionic amphiphile selected from the group consisting of substances having the general formula RC 6 H 4 (OC 2 H 4 ) n OH wherein R is octyl or nonyl and n is at least 3, followed by separating said amphiphile from the resulting depyrogenated product or material by liquid phase separation.
Claim 2
Independent Claim
85 words
The method of depyrogenating a biomedical product or material comprising treating said product or material by prolonged contact with a solution or suspension of about 0.1% to about 10% by weight of a nonionic amphiphile selected from the group consisting of substances having the general formula RC 6 H 4 (OC 2 H 4 ) n OH wherein R is octyl or nonyl and n is at least 3, followed by separating said amphiphile from the resulting depyrogenated product or material by liquid phase separation.
Claim 3
Dependent Claim
14 words
The method of claim 1 in which the amphiphile is octyl phenoxy polyethoxy ethanol.
Claim 4
Dependent Claim
16 words
The method of claim 1 in which the liquid phase separation comprises solvent washing with isopropanol.
Claim 5
Dependent Claim
32 words
The method of claim 1 in which the liquid phase separation comprises solvent phase extraction with an organic solvent selected from the group consisting of butanol, chloroform, toluene, xylene and methylene chloride.
Claim 6
Dependent Claim
16 words
The method of claim 1 in which the liquid phase separation comprises ultrafiltration, diafiltration or dialysis.
Claim 7
Dependent Claim
14 words
The method of claim 5 in which the amphiphile is octyl phenoxy polyethyoxy ethanol.
Claim 8
Dependent Claim
16 words
The method of claim 1 in which the biomedical product or material is a filtration membrane.
Claim 9
Dependent Claim
17 words
The method of claim 1 in which the biomedical product or material is DEAE-coated cross-linked dextran beads.
Claim 10
Dependent Claim
12 words
The method of claim 4 in which the organic solvent is butanol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-31 | 1987-05-02 | 1987-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-31 | 1991-05-02 | 1991-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-31 | 1995-05-02 | 1995-11-01 | $7700.00 | Window Closed / Lapsed |