US4411893A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Topical medicament preparations
Assignee: 3M Co
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Filing: 1982-09-24
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Granted: 1983-10-25
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Expires: 2002-09-24
Abstract
Abstract Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol. The amine oxide enhances penetration of the therapeutic agent into and through the skin.
Inventors
- 👤 Dee L. Johnson
- 👤 Therese A. Senta
- 👤 Larry M. Sirvio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 14:54
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/16; A61K47/18; A61K47/22; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
87 words
A composition for topical application to animal skin comprising: (1) an effective amount of a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol; (2) about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide; and (3) at least 1 molecule of water for every molecule of said amine oxide; said composition exhibiting at least 50 percent greater penetration of said therapeutic agent through mouse skin in 24 hours than a control composition without said amine oxide.
Claim 2
Dependent Claim
87 words
A composition for topical application to animal skin comprising: (1) an effective amount of a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol; (2) about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide; and (3) at least 1 molecule of water for every molecule of said amine oxide; said composition exhibiting at least 50 percent greater penetration of said therapeutic agent through mouse skin in 24 hours than a control composition without said amine oxide.
Claim 3
Dependent Claim
24 words
The composition according to claim 1 further comprising an extending medium compatible with the skin of the animal to which said composition is applied.
Claim 4
Dependent Claim
112 words
The composition according to claims 1 or 2 wherein said amine oxide is selected from the group consisting of: ##STR4## where R 1 , R 2 and R 3 are saturated or unsaturated aliphatic radicals optionally containing, amide or ether linkages and pendent hydroxy groups and the total number of carbon atoms in R 1 +R 2 +R 3 does not exceed 28; ##STR5## X is --O-- or N-R 5 , R 4 and R 5 are saturated or unsaturated aliphatic radicals each containing 1-18 carbon atoms optionally containing ether linkages or pendent hydroxyl groups; P is zero or 1; n is 2 or 3 and m is 2, 3 or 4.
Claim 5
Dependent Claim
38 words
The composition according to claim 1 wherein said amine oxide is selected from the group consisting of trimethylamine oxide, tributylamine oxide, diheptylmethylamine oxide, dimethyldecylamine oxide, dimethyldodecylamine oxide, dimethylcocoamidopropylamine oxide, dipropyl-6-hydroxyhexylamine oxide, dicyclohexylmethylamine oxide, dimethyltetradecylamine oxide, and mixtures thereof.
Claim 6
Dependent Claim
22 words
The composition according to claim 1 wherein said amine oxide is selected from the group consisting of N-cocomorpholine-N-oxide, N-methylpyrrolidine-N-oxide, N-methylmorpholine-N-oxide, and N-methylpiperidine-N-oxide.
Claim 7
Dependent Claim
15 words
The composition according to claim 1 comprising 0.1 to 99 percent by weight of water.
Claim 8
Dependent Claim
18 words
The composition according to claim 1 comprising about 2 to 10 percent by weight of said amine oxide.
Claim 9
Dependent Claim
34 words
A method for the topical treatment or prevention of a disorder of the animal body comprising applying to the skin of said animal body an effective amount of the composition according to claim 1.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-24 | 1987-04-25 | 1987-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-24 | 1991-04-25 | 1991-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-24 | 1995-04-25 | 1995-10-25 | $7700.00 | Window Closed / Lapsed |