US4408077A
Expired / Lapsed
US
⏱️ 0.0 years remaining
6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehydes
Assignee: Wyeth Canada Inc
•
Filing: 1981-11-13
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Granted: 1983-10-04
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Expires: 2001-11-13
Abstract
Abstract A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.
Inventors
- 👤 Kazimir Sestanj
- 👤 Steven Fung
- 👤 Nedumparambil A. Abraham
- 👤 Francesco Bellini
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:42
CPC Classifications
C; C07; C07C; C07C17/00; C07C17/26; C07C17/263; C07C17/2632; C07C29/00; C07C29/58; C07C37/00; C07C37/06; C07C37/07; C07C43/00; C07C43/02; C07C43/20; C07C43/225; C07C45/00; C07C45/004; C07C45/42; C07C47/00; C07C47/52; C07C47/575; C07C49/00; C07C49/20; C07C49/213; C07C49/217; C07C49/223
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
2 words
6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde.
Claim 2
Dependent Claim
2 words
6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde.
Claim 3
Dependent Claim
6 words
6-(Methoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde, as claimed in claim 1.
References Cited (Backward Citations)
US3977949A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-03 | 1987-04-04 | 1987-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-03 | 1991-04-04 | 1991-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-03 | 1995-04-04 | 1995-10-04 | $7700.00 | Window Closed / Lapsed |