US4407796A
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Modulators of the complement system
Assignee: Wyeth Holdings LLC
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Filing: 1981-12-28
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Granted: 1983-10-04
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Expires: 2001-12-28
Abstract
Abstract Poly-cation salts of bis-(or tris-) [polyhexaose-thio (or sulfinyl, or sulfonyl)]-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
Inventors
- 👤 Thomas G. Miner
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 13:48
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/04
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
105 words
A compound selected from those of the formula: ##STR5## wherein X is --SO 3 M and M is a nontoxic pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ); A is selected from the group consisting of S, SO and SO 2 ; n is an integer 2 or 3; and B is an arylene selected from the group consisting of ##STR6##
Claim 2
Dependent Claim
105 words
A compound selected from those of the formula: ##STR5## wherein X is --SO 3 M and M is a nontoxic pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ); A is selected from the group consisting of S, SO and SO 2 ; n is an integer 2 or 3; and B is an arylene selected from the group consisting of ##STR6##
Claim 3
Dependent Claim
27 words
The compound according to claim 1, 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecatriethylamine salt, where the structure is ##STR7## wherein M is N + H(C 2 H 5 ) 3 .
Claim 4
Dependent Claim
27 words
The compound according to claim 1, 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecatriethylamine salt, where the structure is ##STR8## wherein M is N + H(C 2 H 5 ) 3 .
Claim 5
Dependent Claim
27 words
The compound according in claim 1, 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, tetradecakis(H-sulfate), tetradecatriethylamine salt, where the structure is ##STR9## wherein M is N + H(C 2 H 5 ) 3 .
Claim 6
Dependent Claim
15 words
The compound according to claim 1, 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecasodium salt, where the structure is ##STR10##
Claim 7
Dependent Claim
15 words
The compound according to claim 1, 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecasodium salt, where the structure is ##STR11##
Claim 8
Dependent Claim
15 words
The compound according to claim 1, 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, tetradecakis(H-sulfate), tetradecasodium salt, where the structure is ##STR12##
Claim 9
Dependent Claim
34 words
A method of modulating the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement modulating amount of a pharmaceutically acceptable compound of claim 1.
Claim 10
Dependent Claim
13 words
The method according to claim 8, wherein the body fluid is blood serum.
Claim 11
Dependent Claim
31 words
A method of modulating the complement system in a warm-blooded animal which comprises administering to said warm-blooded animal an effective complement modulating amount of a pharmaceutically acceptable compound of claim 1.
Claim 12
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecatriethylamine salt.
Claim 13
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecatriethylamine salt.
Claim 14
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, tetradecakis-(H-sulfate), tetradecatriethylamine salt.
Claim 15
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecasodium salt.
Claim 16
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecakis(H-sulfate), tetradecasodium salt.
Claim 17
Dependent Claim
16 words
The method according to claim 8 or 10, wherein the compound is 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, tetradecakis-(H-sulfate), tetradecasodium salt.
Claim 18
Dependent Claim
12 words
The method according to claim 10, wherein the compound is administered internally.
Claim 19
Dependent Claim
12 words
The method according to claim 10, wherein the compound is administered topically.
Claim 20
Dependent Claim
16 words
The method according to claim 10, wherein the compound is administered periodontally in the oral cavity.
Claim 21
Dependent Claim
12 words
The method according to claim 10, wherein the compound is administered intra-articularly.
Claim 22
Dependent Claim
12 words
The method according to claim 10, wherein the compound is administered parenterally.
Claim 23
Dependent Claim
56 words
A compound selected from those of the formula: ##STR13## wherein Y is selected from the group consisting of H and --COCH 3 ; A is selected from the group consisting of S, SO and SO 2 ; n is an integer 2 or 3; and B is an arylene selected from the group consisting of ##STR14##
Claim 24
Dependent Claim
56 words
A compound selected from those of the formula: ##STR13## wherein Y is selected from the group consisting of H and --COCH 3 ; A is selected from the group consisting of S, SO and SO 2 ; n is an integer 2 or 3; and B is an arylene selected from the group consisting of ##STR14##
Claim 25
Dependent Claim
12 words
The compound according to claim 22, 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, where the structure is ##STR15##
Claim 26
Dependent Claim
19 words
The compound according to claim 22, 1,3-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecaacetate, where the structure is ##STR16## wherein Y is --COCH 3 .
Claim 27
Dependent Claim
12 words
The compound according to claim 22, 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, where the structure is ##STR17##
Claim 28
Dependent Claim
19 words
The compound according to claim 22, 1,3-bis-[4-O-β-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-phenylene, tetradecaacetate, where the structure is ##STR18## wherein Y is --COCH 3 .
Claim 29
Dependent Claim
12 words
The compound according to claim 22, 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, where the structure is ##STR19##
Claim 30
Dependent Claim
19 words
The compound according to claim 22, 4,4'-bis-[4-O-α-D-glucopyranosyl-β-D-glucopyranosyl-1-thio]-1,1'-biphenylene, tetradecaacetate, where the structure is ##STR20## wherein Y is --COCH 3 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-10-03 | 1987-04-04 | 1987-10-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-10-03 | 1991-04-04 | 1991-10-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-10-03 | 1995-04-04 | 1995-10-04 | $7700.00 | Window Closed / Lapsed |