US4407791A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Ophthalmic solutions
Assignee: Alcon Research LLC
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Filing: 1981-09-28
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Granted: 1983-10-04
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Expires: 2001-09-28
Abstract
Abstract This invention relates to the quaternary ammonium salt, alpha -4-[-tris (2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride, providing aqueous disinfecting solutions for contact lenses as well as a preservative for ocular solutions including contact lens treating solutions.
Inventors
- 👤 Raymond L. Stark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 15:47
CPC Classifications
A; A61; A61L; A61L12/00; A61L12/08; A61L12/14; A61L12/143; A61L12/145; A61K; A61K31/00; A61K31/74; A61K31/785; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02; A61P31/00; A61P31/04; Y; Y02; Y02A; Y02A50/00; Y02A50/30
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
40 words
A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising: adding to said solution from about 0.00001% to about 3.0% by weight/volume of α-4-[1-tris(2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.
Claim 2
Independent Claim
40 words
A method of imparting antimicrobial activity to an aqueous ophthalmic contact lens solution comprising: adding to said solution from about 0.00001% to about 3.0% by weight/volume of α-4-[1-tris(2-hydroxyethyl) ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.
Claim 3
Dependent Claim
27 words
A method as recited in claim 1 wherein said antimicrobial agent preserves said solution and comprises from about 0.0001% to about 0.005% by weight/volume of said solution.
Claim 4
Dependent Claim
31 words
A method as recited in claim 1 wherein said antimicrobial agent comprises from about 0.001% to about 0.01% by weight/volume of said solution and wherein said solution disinfects a contact lens.
Claim 5
Dependent Claim
30 words
A method as recited in claim 2 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.
Claim 6
Dependent Claim
34 words
A method as recited in claim 2 comprising further adding to said ophthalmic solution from about 0.01% to about 0.2% by weight/volume of polyvinylalcohol and from about 0.001% to about 0.005% by weight/volume thimerosal.
Claim 7
Dependent Claim
23 words
A method as recited in claim 2 comprising further adding to said ophthalmic solution about 0.01% to about 0.2% by weight/volume of polyvinylpyrrolidone.
Claim 8
Dependent Claim
36 words
A method as recited in claim 2 comprising further adding to said ophthalmic solution disodium edetate, sodium chloride and a buffer, said ophthalmic solution having a pH in the range of about 5.0 to about 8.5.
Claim 9
Dependent Claim
24 words
A method as recited in claim 4 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.
Claim 10
Dependent Claim
30 words
A method as recited in claim 3 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.
Claim 11
Dependent Claim
21 words
A method as recited in claim 3 wherein said ophthalmic solution further comprises about 0.01% to about 0.2% by weight/volume polyvinylpyrrolidone.
Claim 12
Dependent Claim
32 words
A method as recited in claim 3 wherein said solution comprises from about 0.01% to about 0.2% by weight/volume of polyvinyl alcohol and from about 0.001% to about 0.005% by weight/volume thimerosal.
Claim 13
Dependent Claim
34 words
A method as recited in claim 3 wherein said solution further comprises disodium edetate, sodium chloride, and a buffer, said ophthalmic solution having a pH in the range of about 5.0 to about 8.5.
Claim 14
Dependent Claim
24 words
A method as recited in claim 9 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.
Claim 15
Independent Claim
37 words
A method of disinfecting a contact lens comprising: contacting said lens with a solution comprising from about 0.001% to about 0.01% by weight/volume of α-4-[1-tris(2-hydroxyethyl ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.
Claim 16
Independent Claim
37 words
A method of disinfecting a contact lens comprising: contacting said lens with a solution comprising from about 0.001% to about 0.01% by weight/volume of α-4-[1-tris(2-hydroxyethyl ammonium chloride-2-butenyl] poly[1-dimethyl ammonium chloride-2-butenyl]-w-tris (2-hydroxyethyl) ammonium chloride as an antimicrobial agent.
Claim 17
Dependent Claim
30 words
A method as recited in claim 14 wherein said antimicrobial agent has a molecular weight sufficiently large to substantially preclude adsorption, absorption or physical binding onto a soft contact lens.
Claim 18
Dependent Claim
24 words
A method as recited in claim 15 wherein said antimicrobial agent has a molecular weight in the range from about 1200 to about 3100.
Claim 19
Dependent Claim
29 words
A method as recited in claim 15 further comprising heating said ophthalmic solutions and said contact lens in a temperature range from about 60° C. to about 100° C.
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