US4405644A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Medicaments for the treatment of disorders of lipometabolism and their use
Assignee: Bayer AG
•
Filing: 1981-12-17
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Granted: 1983-09-20
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Expires: 2001-12-17
Abstract
Abstract The invention relates primarily to pharmaceutical compositions and medicaments containing a compound of Formula (I), infra as the active ingredient. Also included in the invention are methods for combatting lipometabolic illnesses by administration of an active compound of the invention alone, in combination with a diluent or in the form of a medicament.
Inventors
- 👤 Hans-Joachim Kabbe
- 👤 Erich Klauke
- 👤 Hans P. Krause
- 👤 Mithat Mardin
- 👤 Rudiger Sitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 05:47
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/72; C07D213/75; A; A61; A61P; A61P3/00; A61P3/06; C07C; C07C275/00; C07C275/28; C07C275/30; C07D215/00; C07D215/02; C07D215/16; C07D215/38; C07D215/42; C07D249/00; C07D249/02; C07D249/04; C07D249/06; C07D251/00; C07D251/02; C07D251/12; C07D251/14; C07D251/22; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/44; C07D277/48; C07D277/60; C07D277/62; C07D277/68; C07D277/82; C07D279/00; C07D279/02; C07D279/04; C07D279/08; C07D295/00; C07D295/04; C07D295/12; C07D295/14; C07D295/155; C07D307/00; C07D307/77; C07D307/91; C07D317/00; C07D317/08; C07D317/44; C07D317/46
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
172 words
A method of combating lipometabolic illnesses in warm-blooded animals which comprises administering to the animals a hypolipidemically effective amount of a urea derivative of the formula ##STR367## in which R 3 and R 4 are identical or different and in each case represent a mono-or bi-cyclic carbocyclic aryl radical, optionally substituted by 1 or 2 identical or different substituents selected from cyano, halogen, alkyl, alkoxy and alkylmercapto, the alkyl, alkoxy and alkylmercapto radicals mentioned being in turn substituted by 1 or more fluorine atoms with the proviso that (a) R 3 and R 4 contain a total of 2 or 3 substituents including a total of 1 or 2 halogen substituents (b) R 3 and R 4 are devoid of ortho substituents and (c) R 3 and R 4 are so chosen that p,p'-substituted compounds and m,m'-disubstituted compounds in which the substituents are fluorinated alkyl groups are excluded, and X represents an oxygen or sulphur atom either alone or in admixture with an inert carrier or in the form of a medicament.
Claim 2
Independent Claim
172 words
A method of combating lipometabolic illnesses in warm-blooded animals which comprises administering to the animals a hypolipidemically effective amount of a urea derivative of the formula ##STR367## in which R 3 and R 4 are identical or different and in each case represent a mono-or bi-cyclic carbocyclic aryl radical, optionally substituted by 1 or 2 identical or different substituents selected from cyano, halogen, alkyl, alkoxy and alkylmercapto, the alkyl, alkoxy and alkylmercapto radicals mentioned being in turn substituted by 1 or more fluorine atoms with the proviso that (a) R 3 and R 4 contain a total of 2 or 3 substituents including a total of 1 or 2 halogen substituents (b) R 3 and R 4 are devoid of ortho substituents and (c) R 3 and R 4 are so chosen that p,p'-substituted compounds and m,m'-disubstituted compounds in which the substituents are fluorinated alkyl groups are excluded, and X represents an oxygen or sulphur atom either alone or in admixture with an inert carrier or in the form of a medicament.
Claim 3
Dependent Claim
27 words
A method according to claim 1 in which the active compound is administered in an amount of 5 to 100 mg per kg body weight per day.
Claim 4
Independent Claim
16 words
A method according to claims 1 or 2 in which the active compound is administered orally.
Claim 5
Dependent Claim
13 words
A method according to claim 1 in which the active ingredient is N-3-trifluoromethylphenyl-N'-3-chloro-4-trifluoromethylphenyl-urea.
Claim 6
Dependent Claim
14 words
A method according to claim 1 in which the active ingredient is N-3-trifluoromethoxyphenyl-N'-3-chloro-4-trifluoromethylphenyl urea.
Claim 7
Dependent Claim
14 words
A method according to claim 1 in which the active ingredient is N-3-trifluoromethoxyphenyl-N'-3-trifluoromethyl-4-chlorophenyl urea.
Claim 8
Dependent Claim
14 words
A method according to claim 1 in which the active ingredient is N-3-trifluoromethoxyphenyl-N'-3-trifluoromethylphenyl urea.
Claim 9
Dependent Claim
14 words
A method according to claim 1 in which the active ingredient is N-4-trifluoromethylphenyl-N'-3-cyanophenyl urea.
Claim 10
Dependent Claim
14 words
A method according to claim 1 in which the active ingredient is N-4-trifluoromethoxyphenyl-N'-3-cyanophenyl urea.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |