US4405596A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparations for and treatment procedures involving increasing plasma bicarbonate level
Assignee: Individual
•
Filing: 1981-09-15
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Granted: 1983-09-20
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Expires: 2001-09-15
Abstract
Abstract The invention concerns a novel pharmaceutical preparation and methods of treatment associated therewith. More particularly, the invention is concerned with pharmaceutical preparations adapted to form or release resorbable bicarbonate ions only in the intestine of the subject. The oral dosage forms of the invention may comprise further active agents, and trace elements. The dosage forms are for example useful in treating patients suffering from abnormal distribution or retention of body fluids or retention products, i.e. products which should be or which should desirably be cleared by kidney function.
Inventors
- 👤 Joachim W. Helbig
- 👤 Klaus F. Kopp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 02:45
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/14
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
122 words
A pharmaceutical oral dosage form for use in treating altered renal function or prophylactically conditioning against such alterations of an active agent capable of forming or releasing bicarbonate ions and being for increasing plasma bicarbonate level of a subject to a value in excess of that prior to treatment, characterised in that said oral dosage form is substantially free of undesirable side effects known to exist for oral dosage forms of gastro-intestinal bicarbonate-releasing preparations, the active agent being one which forms or releases or which has been adapted in the oral dosage form to form or release resorbable bicarbonate ions only in the intestine of a subject without the possibility of reaction thereof with gastric secretions in the stomach of the subject.
Claim 2
Dependent Claim
122 words
A pharmaceutical oral dosage form for use in treating altered renal function or prophylactically conditioning against such alterations of an active agent capable of forming or releasing bicarbonate ions and being for increasing plasma bicarbonate level of a subject to a value in excess of that prior to treatment, characterised in that said oral dosage form is substantially free of undesirable side effects known to exist for oral dosage forms of gastro-intestinal bicarbonate-releasing preparations, the active agent being one which forms or releases or which has been adapted in the oral dosage form to form or release resorbable bicarbonate ions only in the intestine of a subject without the possibility of reaction thereof with gastric secretions in the stomach of the subject.
Claim 3
Dependent Claim
28 words
A pharmaceutical oral dosage form according to claim 1, in which the active agent is one which forms or releases bicarbonate ions following reaction thereof with intestinal secretions.
Claim 4
Dependent Claim
30 words
A pharmaceutical oral dosage form according to claim 2, in which the active agent is one which forms or releases bicarbonate ions following reaction with enzymes present in intestinal secretions.
Claim 5
Dependent Claim
53 words
A pharmaceutical oral dosage form according to claim 1, in which the active agent has been adapted to form or release bicarbonate ions only in the intestine of the subject by being associated with an additional substance enabling the active agent to form or release bicarbonate ions only following reaction with intestinal secretions.
Claim 6
Dependent Claim
26 words
A pharmaceutical oral dosage form according to claim 4, in which said additional substance comprises enzymes which are activated only in the environment of the intestine.
Claim 7
Dependent Claim
19 words
A pharmaceutical oral dosage form according to claim 4, in which said additional substance comprises a gastric-secretion-resistant intestine-secretion-decomposable material.
Claim 8
Dependent Claim
21 words
A pharmaceutical oral dosage form according to claim 5, in which the active agent has been coated with said additional substance.
Claim 9
Dependent Claim
21 words
A pharmaceutical oral dosage form according to claim 7, in which the gastric-juice-resistant small-intestine-decomposable enclosure comprises a gastric-juice resistant acrylic resin.
Claim 10
Dependent Claim
40 words
A pharmaceutical oral dosage form according to claim 7, in which the gastric-juice resistant small-intestine-decomposable enclosure is a capsule enclosure rendered resistant to gastric juice with the aid of a mixture of gelatine hydroxypropyl methyl cellulose phthalate and dibutyl phthalate.
Claim 11
Dependent Claim
35 words
A pharmaceutical oral dosage form according to claim 7, in which the gastric-juice-resistant small-intestine-decomposable enclosure is a tablet coating rendered resistant to gastric juice with the aid of cellulose acetate phthalate and an acrylic resin.
Claim 12
Dependent Claim
42 words
A pharmaceutical preparation according to claim 1, in which the active agent is selected from the group consisting of a bicarbonate, a carbonate, or a mixture of a bicarbonate and a carbonate at a ratio by weight of from 1:10 to 10:1.
Claim 13
Dependent Claim
49 words
A pharmaceutical oral dosage form according to claim 1, in which the active agent is associated with a further active substance suitable for the prophylaxis and therapy of kidney stones, selected from the group consisting of an alkali metal or alkaline earth metal salt of citric acid, and urea.
Claim 14
Dependent Claim
27 words
A pharmaceutical oral dosage form according to claim 1, in which the active agent is associated with a calcium compound suitable for supplementing calcium in the subject.
Claim 15
Dependent Claim
17 words
A pharmaceutical oral dosage form according to claim 13, in which the calcium compound is calcium gluconate.
Claim 16
Dependent Claim
27 words
A pharmaceutical oral dosage form according to claim 1, in which the active agent is associated with a potassium compound suitable for supplementing potassium in the subject.
Claim 17
Dependent Claim
28 words
A pharmaceutical oral dosage form according to claim 15, in which the potassium compound is selected from the group consisting of potassium chloride, potassium bicarbonate, and potassium citrate.
Claim 18
Dependent Claim
42 words
A pharmaceutical oral dosage form according to claim 2, in unit dosage form, comprising from about 200 to about 1500 mg of a bicarbonate enclosed within a gastric-juice-resistant small-intestine-decomposable enclosure enabling release of bicarbonate ions only in the intestine of the subject.
Claim 19
Dependent Claim
29 words
A pharmaceutical oral dosage form according to claim 1, in which trace elements recognised to contribute to the general well-being of subjects are included in the oral dosage form.
Claim 20
Dependent Claim
47 words
A method of preventing severe impediment of renal function or acute renal failure, which comprises the step of orally administering to a patient likely to contract such severe impediment of renal function or renal failure, a prophylactically effective amount of the oral dosage form of claim 1.
Claim 21
Dependent Claim
35 words
A method according to claim 19, in which the prophylactically effective amount is sufficient to correct at least in part conditions of metabolic acidosis which precede severe impediment of renal function or acute renal failure.
Claim 22
Dependent Claim
19 words
A method according to claim 19, in which the prophylactically effective amount is sufficient to induce increased urine volume.
Claim 23
Dependent Claim
54 words
A method according to claim 19, in which the patient likely to contract severe impediment of renal function or renal failure is one suffering from altered renal function and which patient is to be subjected to a procedure likely to lead to severe impediment of renal function or acute renal failure in such patients.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-19 | 1987-03-21 | 1987-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-19 | 1991-03-21 | 1991-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-19 | 1995-03-21 | 1995-09-20 | $7700.00 | Window Closed / Lapsed |