Piperazinyl-substituted imidazoles

Claim 1

A compound according to formula I ##STR2## or a pharmacologically acceptable salt thereof, wherein X 1 is (a) ═CH--; or (b) ═C(CH 3 )--; wherein m is zero, one, 2 or 3; wherein n is zero, one or 2, wherein R 4 is: (a) hydrogen; (b) alkyl of one to three carbon atoms, inclusive; (c) R 54 OCH 2 --, wherein R 54 is defined below; (d) --CH(R 35 )(OH); or (e) --R 35 ; wherein R 5 , R 15 , R 25 and R 35 are the same or different and are (i) 2,3, or 4 pyridinyl, or (ii) phenyl substituted by zero to 2 chloro, fluoro, bromo, alkyl of from one to 3 carbon atoms, or alkoxy of from one to 3 carbon atoms, or (iii) phenyl substituted by one trifluoromethyl and zero to one of the previous phenyl substituents, wherein R 6 is: (a) hydrogen; (b) --OR 54 ; (c) alkanoyloxy of from one to 3 carbon atoms; or (d) alkyl of from one to 3 carbon atoms; with the proviso that when m is zero, R 6 does not contain oxygen; wherein R 7 is (i) hydrogen, (ii) methyl, (iii) phenylmethyl, or (iv) phenylethyl, wherein R 8 is (i) --R 15 ; (ii) --CH 2 R 15 , or (iii) --CHR 15 R 25 ; wherein R 17 is methyl, phenyl, benzyl, or 2-phenylethyl; and wherein R 54 is hydrogen or alkyl of one to 3 carbon atoms; or an enantiomer (when R 4 is --CH(R 35 )OH or when R 6 is not hydrogen) or diastereomer (when R 4 is --CH(R 35 )OH and R 6 is not hydrogen) of such compound.