US4401663A
Expired / Lapsed
US
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Novel sulfonamide derivatives
Assignee: Procter and Gamble Co
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Filing: 1982-03-23
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Granted: 1983-08-30
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Expires: 2002-03-23
Abstract
Abstract A compound, or pharmaceutically acceptable salt thereof, having the formula: <IMAGE> wherein X is <IMAGE> wherein R is C3-C12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C3-C22 alkenyl, branched or unbranched; wherein R1 is H, OH or OCH3, and wherein R2 is OH or H, at least one of R1 and R2 being OH or OCH3. These sulfonamides have analgesic and anti-irritant activity when administered to humans and lower animals.
Inventors
- 👤 Brian L. Buckwalter
- 👤 Thomas R. LaHann
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 03:25
CPC Classifications
A; A61; A61Q; A61Q9/00; A61Q9/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K8/466; A61Q17/00; A61K2800/00; A61K2800/74; A61K2800/75
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
71 words
Compounds of formula: ##STR7## wherein X is ##STR8## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
71 words
Compounds of formula: ##STR7## wherein X is ##STR8## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
The sodium, potassium, calcium, magnesium, or ammonium salt of the compounds of claim 1.
Claim 4
Dependent Claim
12 words
A compound or salt according to claim 1 wherein X is ##STR9##
Claim 5
Dependent Claim
18 words
A compound according to claim 3 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 6
Dependent Claim
24 words
A compound or salt according to claim 4 wherein R is C 6 -C 12 alkyl or aralkyl, or C 6 -C 22 alkenyl.
Claim 7
Dependent Claim
14 words
A compound or salt according to claim 5 wherein R is n-heptyl or n-octyl.
Claim 8
Dependent Claim
96 words
A pharmaceutical composition in unit dosage form having analgesic activity which comprises a safe and effective amount of a compound of formula: ##STR10## wherein X is ##STR11## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
96 words
A pharmaceutical composition in unit dosage form having analgesic activity which comprises a safe and effective amount of a compound of formula: ##STR10## wherein X is ##STR11## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, unsubstituted aryl, haloaryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
20 words
A composition according to claim 7 wherein the pharmaceutically acceptable salt is a sodium, potassium, calcium, magnesium, or ammonium salt.
Claim 11
Dependent Claim
10 words
A composition according to claim 7 wherein X is ##STR12##
Claim 12
Dependent Claim
18 words
A composition according to claim 9 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 13
Dependent Claim
22 words
A composition according to claim 10 wherein R is C 6 -C 12 alkyl or aralkyl, or C 6 -C 22 alkenyl.
Claim 14
Dependent Claim
12 words
A composition according to claim 11 wherein R is n-heptyl or n-octyl.
Claim 15
Independent Claim
102 words
A method for providing analgesia in humans and lower animals in need thereof, which comprises the step of administering to the human or lower animal a safe and effective amount of a compound of formula: ##STR13## wherein X is ##STR14## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; or a pharmaceutically acceptable salt thereof.
Claim 16
Independent Claim
102 words
A method for providing analgesia in humans and lower animals in need thereof, which comprises the step of administering to the human or lower animal a safe and effective amount of a compound of formula: ##STR13## wherein X is ##STR14## wherein R is C 3 -C 12 alkyl or aralkyl, branched or unbranched, aryl, or C 3 -C 22 alkenyl, branched or unbranched, wherein R 1 is H, OH or OCH 3 , and wherein R 2 is H or OH, at least one of R 1 and R 2 being OH or OCH 3 ; or a pharmaceutically acceptable salt thereof.
Claim 17
Dependent Claim
15 words
A method according to claim 13 in which the compound or salt is administered topically.
Claim 18
Dependent Claim
15 words
A method according to claim 13 in which the compound or salt is administered parenterally.
Claim 19
Dependent Claim
15 words
A method according to claim 15 in which the compound or salt is administered intramuscularly.
Claim 20
Dependent Claim
15 words
A method according to claim 15 in which the compound or salt is administered subcutaneously.
Claim 21
Dependent Claim
16 words
A method according to claim 13 in which the compound is administered in sequentially increasing doses.
Claim 22
Dependent Claim
20 words
A method according to claim 18 in which the doses are separated by a period of at least 2 hours.
Claim 23
Dependent Claim
10 words
A method according to claim 13 wherein X is ##STR15##
Claim 24
Dependent Claim
18 words
A method according to claim 20 wherein R 1 is OCH 3 and wherein R 2 is OH.
Claim 25
Dependent Claim
22 words
A method according to claim 21 wherein R is C 6 -C 12 alkyl or aralkyl, or C 6 -C 22 alkenyl.
Claim 26
Dependent Claim
19 words
A depilatory composition having reduced dermal irritation, which comprises: (a) a depilatory amount of a thioglycolate depilatory agent, and
Claim 27
Dependent Claim
19 words
A depilatory composition having reduced dermal irritation, which comprises: (a) a depilatory amount of a thioglycolate depilatory agent, and
Claim 28
Dependent Claim
25 words
(b) a compound or salt according to claim 1 in an amount effective to prevent or reduce the dermal irritation of the thioglycolate depilatory agent.
Claim 29
Dependent Claim
13 words
A composition according to claim 23 which further comprises a pharmaceutically acceptable carrier.
Claim 30
Dependent Claim
59 words
A method for preventing or reducing the dermal irritation caused by a thioglycolate depilatory agent, which comprises the step of applying to at least a portion of a depilated area a compound or salt according to claim 1 in an amount effective to prevent or reduce irritation caused by treatment of the depilated area with a thioglycolate depilatory agent.
Claim 31
Dependent Claim
26 words
A method according to claim 25 wherein X is ##STR16## wherein R is n-octyl, wherein R 1 is OCH 3 and wherein R 2 is OH.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-29 | 1987-02-28 | 1987-08-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-29 | 1991-02-28 | 1991-08-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-29 | 1995-02-28 | 1995-08-30 | $7700.00 | Window Closed / Lapsed |