US4399065A
Expired / Lapsed
US
⏱️ 0.0 years remaining
D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate and process for the preparation thereof
Assignee: Patentbureau Danubia
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Filing: 1982-01-05
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Granted: 1983-08-16
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Expires: 2002-01-05
Abstract
Abstract The invention relates to D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate, highly stable in aqueous solution, and to a process for preparing it from D-phenylalanyl-L-prolyl-L-arginine aldehyde hemisulfate or NG-carboxy derivative containing an acid-sensitive protecting group at its amino terminal, wherein the acid sensitive amino terminal protecting group or optionally the NG-carboxy group is removed with 1 to 12 N sulfuric acid, applied in 1 to 12 equivalent amounts and the resulting free tripeptide aldehyde sulfate is isolated. The D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate of the invention possesses valuable anticoagulant activity.
Inventors
- 👤 Sandor Bajusz
- 👤 Erzsebet Szell nee Hasenohrl
- 👤 Eva Barabas
- 👤 Daniel Bagdy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 08:59
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06078; A; A61; A61P; A61P7/00; A61P7/02; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
8 words
D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate highly stable in aqueous solution.
Claim 2
Dependent Claim
8 words
D-Phenylalanyl-L-prolyl-L-arginine aldehyde sulfate highly stable in aqueous solution.
Claim 3
Dependent Claim
24 words
A pharmaceutical composition for use as an anticoagulant which comprises a pharmaceutically acceptable carrier and/or diluent and an effective amount of D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate.
Claim 4
Dependent Claim
24 words
A pharmaceutical composition for use as an anticoagulant which comprises a pharmaceutically acceptable carrier and/or diluent and an effective amount of D-phenylalanyl-L-prolyl-L-arginine aldehyde sulfate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-15 | 1987-02-14 | 1987-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-15 | 1991-02-14 | 1991-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-15 | 1995-02-14 | 1995-08-16 | $7700.00 | Window Closed / Lapsed |