Measuring low flowrates

Claim 2

Apparatus for making a measurement of the flowrate of a flowing liquid subject to short-term variations in flowrate comprising a vertically-positioned collection tube with a known volume-versus-height relationship, means for directing said flowing liquid into said collection tube, means for periodically generating electrical signals representing the height of the surface of said liquid in said tube at different times while said height is increasing during a collection interval in which there are short-term variations in flowrate, and means for receiving said signals and determining the time-averaged flowrate value at the end of said collection interval based on a succession of height-versus-time data taken during said collection interval to avoid distortion of flowrate value owing to said short-term variations.

Claim 3

The apparatus of claim 1 further comprising a first port for removing liquid in said tube before and after making said measurement, and a first valve means connected to said first port to block flow through said port while said measurement is being made.

Claim 4

The apparatus of claim 2 further comprising a source of pressurized air connected to said tube for removing said liquid prior to measuring at a time when said first valve means is open.

Claim 5

The apparatus of claim 3 further comprising a second port on said collection tube located above the highest point reached by said surface in said tube during said measurement, and valve means connected to said second port to allow air above said surface to exit through said second port while said surface is rising and to facilitate discharge through said first port while said first valve means is open and air is being forced into said tube prior to a measurement.

Claim 6

The apparatus of claim 4 wherein said source is connected to said tube through said second port.

Claim 7

The apparatus of claim 1 or 4 wherein said means for generating electrical signals is a sonic transmitter and receiver located at the bottom of said tube.

Claim 8

Apparatus for making a measurement of the ultrafiltration flowrate in a fluid flow transfer device having a first liquid flowing on one side of a semipermeable membrane at a first pressure and a second liquid flowing on the othe side of said membrane at a lower pressue, said ultrafiltration being subject to short-term variations in flowrate, said apparatus comprising, a vertically-positioned collection tube with a known volume-versus-height relationship, means for directing a flow of liquid equal in amount to that resulting from ultrafiltration into said collection tube, means for periodically generating electrical signals representing the height of the surface of liquid in said tube at different times while said height is increasing during a collection interval in which there are short-term variations in flowrate, and means for receiving said signals and determining the time-averaged flowrate value at the end of said collection interval based on a succession of height-versus-time data taken during said collection interval to avoid distortion of flowrate value owing to said short-term variations.

Claim 9

Apparatus for making a measurement of the ultrafiltration flowrate in a fluid flow transfer device having a first liquid flowing on one side of a semipermeable membrane at a first pressure and a second liquid flowing on the othe side of said membrane at a lower pressue, said ultrafiltration being subject to short-term variations in flowrate, said apparatus comprising, a vertically-positioned collection tube with a known volume-versus-height relationship, means for directing a flow of liquid equal in amount to that resulting from ultrafiltration into said collection tube, means for periodically generating electrical signals representing the height of the surface of liquid in said tube at different times while said height is increasing during a collection interval in which there are short-term variations in flowrate, and means for receiving said signals and determining the time-averaged flowrate value at the end of said collection interval based on a succession of height-versus-time data taken during said collection interval to avoid distortion of flowrate value owing to said short-term variations.

Claim 10

The apparatus of claim 7 further comprising a first port for removing liquid collected in said tube before and after making said measurement, and a first valve means connected to said first port to block flow through said port while said measurement is being made.

Claim 11

The apparatus of claim 8 further comprising a source of pressurized air connected to said tube for removing said liquid prior to measuring at a time when said first valve means is open.

Claim 12

The apparatus of claim 9 further comprising a second port on said collection tube located above the highest point reached by said surface in said tube during said measurement, and valve means connected to said second port to allow air above said surface to exit through said second port while said surface is rising and to facilitate discharge through said first port while said first valve means is open and air is being forced into said tube prior to a measurement.

Claim 13

The apparatus of claim 10 wherein said source is connected to said tube through said second port.

Claim 14

The apparatus of claim 11 wherein said means for generating electrical signals is a sonic transmitter and receiver located at the bottom of said tube.

Claim 15

The apparatus of claim 7, 10, or 12 wherein said means for directing a flow comprises valve means for temporarily blocking the flow of said second liquid into said fluid flow transfer device, and means for directing all of the flow of said second liquid into said collection tube.

Claim 16

The apparatus of claim 7, 10, or 12 wherein said means for directing a flow comprises valve means for temporarily blocking the flow of said second liquid into said fluid flow transfer device, and means for directing all of the flow of said second liquid into said collection tube, and wherein said first liquid is blood and said second liquid is dialysate, and further comprising means to initially adjust the dialysate pressure to a value sufficiently high to avoid degassing which would occur at a lower pressure and displace liquid and incorrectly increase the measured amount of liquid collected in said tube.

Claim 19

The method of claim 15 further comprising providing a first port and a first valve means connected to said first port, removing liquid in said tube before and after making said measurement, and blocking flow through said port while said measurement is being made.

Claim 20

The method of claim 16 further comprising removing said liquid prior to measurement by introducing pressurized air into said tube at a time when said first valve means is open.

Claim 21

The method of claim 17 further comprising providing a second port on said collection tube located above the highest point reached by said surface in said tube during said measurement and valve means connected to said second port, causing air above said surface to exit through said second port while said surface is rising, and discharging liquid through said first port while said first valve means is open, said second valve means is closed, and air is being forced into said tube prior to a measurement.

Claim 22

The method of claim 18 wherein said pressurized air is introduced into said tube through said second port.

Claim 23

The method of claim 19 wherein said means for generating electrical signals is a sonic transmitter and receiver located at the bottom of said tube.

Claim 24

The method of claim 15, 18 or 20 wherein said liquid is ultrafiltrate from a dialyzer, and said directing step comprises temporarily blocking the flow of fresh dialysate to said dialyzer and directing all of the flow of spent dialysate from said dialyzer to said collection tube.

Claim 25

The method of claim 15, 18 or 20 wherein said liquid is ultrafiltrate from a dialyzer, and said directing step comprises temporarily blocking the flow of fresh dialysate to said dialyzer and directing all of the flow of spent dialysate from said dialyzer to said collection tube, and prior to said directing step, adjusting the dialysate pressure to a value sufficiently high to avoid degassing which would occur at a lower pressure and displace liquid and incorrectly increase the measured amount of liquid collected in said tube.