US4395404A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic thymosin β3 and β4 analogues
Assignee: George Washington University
•
Filing: 1982-05-14
•
Granted: 1983-07-26
•
Expires: 2002-05-14
Abstract
Abstract Novel peptides representing fragments of thymosin beta 3 and beta 4 have been synthesized and are active agents affecting regulation, differentiation and function of thymus dependent lymphocytes and macrophages.
Inventors
- 👤 Teresa L. K. Low
- 👤 Allan L. Goldstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:34
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/10; C07K5/1002; C07K5/1005; A; A61; A61P; A61P37/00; A61P37/02; A61P37/04; C07K14/00; C07K14/435; C07K14/575; C07K14/57581; C07K5/08; C07K5/0802; C07K5/0804; C07K5/0806; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/837; Y10S930/00; Y10S930/01; Y10S930/18
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
56 words
A peptide of the formula R-Gly-Glu-Ser-R.sub.1 wherein R represents H-Q, Q-Ala-, Q-Gln-Ala, Q-Glu-Lys-Gln-Ala, Q-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Gln-Glu-Lys-Gly-Ala, Q-Ile-Glu-Gln-Glu-Lys-Gin-Ala, Q-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gin-Ala, or Q-Gln-Sar-wherein Q represents H or acyl; and R 1 represents -OH, -A-C or -A-B-C wherein A represents Asp or Asn, B represents -Glu-Ile-Thr- and C represents -Ala-Lys-Thr-Oh. and the pharmaceutically acceptable acid or base addition salts thereof.
Claim 2
Dependent Claim
56 words
A peptide of the formula R-Gly-Glu-Ser-R.sub.1 wherein R represents H-Q, Q-Ala-, Q-Gln-Ala, Q-Glu-Lys-Gln-Ala, Q-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Gln-Glu-Lys-Gly-Ala, Q-Ile-Glu-Gln-Glu-Lys-Gin-Ala, Q-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-, Q-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gin-Ala, or Q-Gln-Sar-wherein Q represents H or acyl; and R 1 represents -OH, -A-C or -A-B-C wherein A represents Asp or Asn, B represents -Glu-Ile-Thr- and C represents -Ala-Lys-Thr-Oh. and the pharmaceutically acceptable acid or base addition salts thereof.
Claim 3
Dependent Claim
9 words
A peptide according to claim 1 which is H-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.
Claim 4
Dependent Claim
9 words
A peptide according to claim 1 which is H-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.
Claim 5
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.
Claim 6
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gln-Ala-Gly-Glu-Ser-OH.
Claim 7
Dependent Claim
9 words
A peptide according to claim 1 which is H-Ala-Gly-Glu-Ser-OH.
Claim 8
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gly-Glu-Ser-OH.
Claim 9
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gln-Ala-Gly-Glu-Ser-Asp-Ala-Lys-Thr-OH.
Claim 10
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gln-Ala-Gly-Glu-Ser-Asn-Ala-Lys-Thr-OH.
Claim 11
Dependent Claim
11 words
A peptide according to claim 1 which is CH 3 CO-Gln-Sar-Gly-Glu-Ser-Asp-Ala-Lys-Thr-OH.
Claim 12
Dependent Claim
11 words
A peptide according to claim 1 which is CH 3 CO-Gln-Sar-Gly-Glu-Ser-Asn-Ala-Lys-Thr-OH.
Claim 13
Dependent Claim
9 words
A peptide according to claim 1 which is H-Gln-Ala-Gly-Glu-Ser-Asp-Glu-Ile-Thr-Ala-Lys-Thr-OH.
Claim 14
Dependent Claim
39 words
A method for stimulating the production of TdT positive prothymocytes, for inhibiting macrophage migration, or restoring immune responses of steroid suppressed mammalian subject, said method comprising administering to said subject an effective amount of a peptide of claim 1.
References Cited (Backward Citations)
US4261886A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-25 | 1987-01-24 | 1987-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-25 | 1991-01-24 | 1991-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-25 | 1995-01-24 | 1995-07-26 | $7700.00 | Window Closed / Lapsed |