US4394385A
Expired / Lapsed
US
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Treatment of gray matter edema
Assignee: Sanofi SA
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Filing: 1982-01-29
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Granted: 1983-07-19
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Expires: 2002-01-29
Abstract
Abstract The invention relates to the treatment of gray matter edema in the brain or spinal chord by the administration of benzofuranyloxyacetic acids, indeno[5,4-b]furancarboxylic acids, their analogs and salts thereof.
Inventors
- 👤 Edward J. Cragoe, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 13:25
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/34
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
149 words
A method of treating persons with gray matter edema which comprises administering to such a person an effective amount of a compound of the formulae: ##STR2## wherein R 1 is H, CH 3 or Cl R 2 is CH 3 or Cl R 3 is alkyl or alkenyl of one through six carbons; cycloalkyl or cycloalkylalkyl of four through seven carbons; phenyl, unsubstituted or substituted with chloro or methyl; benzyl; or thienyl R 4 is H, alkyl of one through five carbons, or R 4 and R 3 taken together with the carbon to which they are attached may be joined to form a cycloalkyl radical of five or six carbons, and R 5 is (1) furyl, (2) thienyl, (3) phenyl, unsubstituted or substituted with methyl, methoxy or halo, or (4) benzyl, unsubstituted or substituted with methyl or halo or the pharmaceutically acceptable salt, ester, or amide derivative thereof.
Claim 2
Independent Claim
149 words
A method of treating persons with gray matter edema which comprises administering to such a person an effective amount of a compound of the formulae: ##STR2## wherein R 1 is H, CH 3 or Cl R 2 is CH 3 or Cl R 3 is alkyl or alkenyl of one through six carbons; cycloalkyl or cycloalkylalkyl of four through seven carbons; phenyl, unsubstituted or substituted with chloro or methyl; benzyl; or thienyl R 4 is H, alkyl of one through five carbons, or R 4 and R 3 taken together with the carbon to which they are attached may be joined to form a cycloalkyl radical of five or six carbons, and R 5 is (1) furyl, (2) thienyl, (3) phenyl, unsubstituted or substituted with methyl, methoxy or halo, or (4) benzyl, unsubstituted or substituted with methyl or halo or the pharmaceutically acceptable salt, ester, or amide derivative thereof.
Claim 3
Dependent Claim
57 words
The method of claim 1 where R 3 is alkyl of one through five carbons, cycloalkyl or cycloalkylalkyl of four through six carbons, benzyl, phenyl or together with R 4 is tetramethylene; R 4 is H or alkyl of one through five carbons; and R 5 is furyl, thienyl, benzyl, or phenyl substituted with chloro or methyl.
Claim 4
Dependent Claim
57 words
The method of claim 2 where R 1 and R 2 are both chloro or both methyl; R 3 is alkyl of one through three carbons, phenyl cyclobutyl, cyclopentyl, cyclohexyl, or benzyl; R 4 is H, methyl, or ethyl; R 3 together with R 4 are tetramethylene; and R 5 is furyl, thienyl, benzyl, p-chlorophenyl, or p-methoxyphenyl.
Claim 5
Dependent Claim
12 words
The method of claim 3 where the compound is of formula I.
Claim 6
Dependent Claim
31 words
The method of claim 4 where R 1 and R 2 are chloro, and R 3 is phenyl, alkyl of one through three carbons, or cycloalkyl of four through six carbons.
Claim 7
Dependent Claim
20 words
The method of claim 5 where the compound is in α-diastereomer, R 3 is cyclopentyl and R 4 is methyl.
Claim 8
Dependent Claim
20 words
The method of claim 5 where the compound is in α-diastereomer, R 3 is phenyl and R 4 is methyl.
Claim 9
Dependent Claim
20 words
The method of claim 5 where the compound is the β-diastereomer, R 3 is phenyl and R 4 is methyl.
Claim 10
Dependent Claim
22 words
The method of claim 4 where R 1 and R 2 are methyl, R 3 is propyl, and R 4 is H.
Claim 11
Dependent Claim
12 words
The method of claim 3 where the compound is of formula II.
Claim 12
Dependent Claim
10 words
The method of claim 10 where R 5 is 2-furyl.
Claim 13
Dependent Claim
13 words
The method of claim 1 where the compound is in the + configuration.
Claim 14
Dependent Claim
13 words
The method of claim 1 where the compound is in the - configuration.
Claim 15
Dependent Claim
12 words
The method of claim 1 for treating persons with spinal chord injury.
Claim 16
Dependent Claim
10 words
The method of claim 1 for treating persons with hydrocephalus.
Claim 17
Dependent Claim
11 words
The method of claim 1 for treating persons with ischemic stroke.
Claim 18
Dependent Claim
11 words
The method of claim 1 for treating persons with head injury.
References Cited (Backward Citations)
US3931234A
Cited
US3984552A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-18 | 1987-01-17 | 1987-07-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-18 | 1991-01-17 | 1991-07-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-18 | 1995-01-17 | 1995-07-19 | $7700.00 | Window Closed / Lapsed |