US4393076A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-inflammatory and analgesic gel composition
Assignee: Hisamitsu Pharmaceutical Co Inc
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Filing: 1982-02-16
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Granted: 1983-07-12
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Expires: 2002-02-16
Abstract
Abstract An anti-inflammatory analgesic gel composition comprising (1) ketoprofen and/or flurbiprofen as the effective ingredient, as well as (2) a glycol, lower alcohol, water and/or a mixture of a lower alcohol with water, (3) a gel-forming agent and, if desired, (4) a solubilizing agent and/or non-ionic surface-active agent as the ingredients of a gel base for the gel composition.
Inventors
- 👤 Kanji Noda
- 👤 Akira Nakagawa
- 👤 Tetsuya Yamagata
- 👤 Hiroyuki Ide
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 13:46
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/32; A61K31/00; A61K31/185; A61K31/19; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
102 words
An anti-inflammatory and analgesic gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxycellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Claim 2
Dependent Claim
102 words
An anti-inflammatory and analgesic gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxycellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Claim 3
Dependent Claim
36 words
An anti-inflammatory and analgesic gel composition according to claim 1, further comprising up to 20% by weight of a solubilizing agent selected from the group consisting of propylene carbonate, diethyl sebacate, benzyl alcohol and diisopropyl adipate.
Claim 4
Dependent Claim
55 words
An anti-inflammatory and analgesic gel composition according to claim 2, further comprising up to 15% by weight of a surface-active agent selected from the group consisting of sesquioleic acid sorbitan, trioleic acid sorbitan, monooleic acid sorbitan, monostearic acid polyethylene glycol, monooleic polyoxyethylenesorbitan, monolauric acid polyoxyethylenesorbitan, polyoxyethylene nonylphenyl ether, polyoxyethylenecetyl ether, polyoxyethylenelauryl ether and mixtures thereof.
Claim 5
Dependent Claim
24 words
An anti-inflammatory analgesic gel composition according to claim 1, 2 or 3, characterized in that it is kept at a pH value of 4.5-7.0.
Claim 6
Dependent Claim
33 words
A method of improving the anti-inflammatory analgesic effects obtainable with the gel composition of claim 1, 2, or 3 which comprises topically applying said composition to the skin of animals and human beings.
Claim 7
Dependent Claim
18 words
A method according to claim 1, wherein the gel composition is kept at a pH value of 4.5-7.0.
Claim 8
Independent Claim
127 words
A method of improving the anti-inflammatory analgesic effects of an inflammatory analgesic gel compositions which comprises topically applying said composition to the skin of animals and human beings, the gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Claim 9
Independent Claim
127 words
A method of improving the anti-inflammatory analgesic effects of an inflammatory analgesic gel compositions which comprises topically applying said composition to the skin of animals and human beings, the gel composition comprising, by weight, 0.5-10% of ketoprofen as the effective ingredient, 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Claim 10
Dependent Claim
36 words
A method according to claim 7, wherein the gel composition further comprises up to 20% by weight of a solubilizing agent selected from the group consisting of propylene carbonate, diethyl sebacate, diisopropyl adipate and bezyl alcohol.
Claim 11
Dependent Claim
61 words
A method according to claim 8, wherein the gel composition further comprises up to 15% by weight of a surface-active agent selected from the group consisting of sesquioleic acid sorbitan, trioleic acid sorbitan, monooleic acid sorbitan, monostearic acid sorbitan, monolauric acid sorbitan, monostearic acid polyethylene glycol, monooleic acid polyoxyethylenesorbitan, monolauric acid polyoxyethylenesorbitan, polyoxyethylenenonylphyenyl ether, polyoxyethylenecetyl ether, polyoxyethylenelauryl ether and mixtures thereof.
Claim 12
Dependent Claim
22 words
An anti-inflammatory and analgesic gel composition according to claim 1, wherein the alcohol is comprises in an amount by weight of 20-45%.
Claim 13
Dependent Claim
22 words
An anti-inflammatory and analgesic gel composition according to claim 4, characterized in that the pH value is in the range of 5.0-6.5.
Claim 14
Dependent Claim
28 words
A method of improving the anti-inflammatory analgesic effects according to claim 5, wherein the alcohol is comprised in an amount by weight of 20-45% in the gel composition.
Claim 15
Dependent Claim
28 words
A method of improving the anti-inflammatory analgesic effects according to claim 7, wherein the alcohol is comprised in an amount by weight of 20-45% in the gel composition.
Claim 16
Dependent Claim
16 words
A method according to claim 6, wherein the pH value is in the range of 5.0-6.5%.
Claim 17
Dependent Claim
102 words
An anti-inflammatory and analgesic gel composition comprising by weight, 3-7% of ketoprofen as the effective ingredient 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
Claim 18
Dependent Claim
102 words
An anti-inflammatory and analgesic gel composition comprising by weight, 3-7% of ketoprofen as the effective ingredient 2-40% of a glycol selected from the group consisting of propylene glycol, butylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol dodecyl ether and glycerine, 20-55% of water, up to 60% of a lower alcohol selected from the group consisting of ethanol, denatured ethanol, propanol and isopropanol, 0.5-5% of a gelling agent selected from the group consisting of carboxyvinyl polymers, hydroxyethylcellulose, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginic acid-propylene glycol ester and 0.1-3% of a neutralizing agent selected from the group consisting of triethanolamine, diethylamine, triethylamine, diisopropylamine and diisopropanolamine.
References Cited (Backward Citations)
US4230724A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-07-11 | 1987-01-10 | 1987-07-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-07-11 | 1991-01-10 | 1991-07-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-07-11 | 1995-01-10 | 1995-07-12 | $7700.00 | Window Closed / Lapsed |