US4388232A
Expired / Lapsed
US
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Method of producing plasma fractions free of side-effects using fast-reacting antithrombin
Assignee: Oesterreichisches Institut fuer Haemoderivate
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Filing: 1982-05-05
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Granted: 1983-06-14
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Expires: 2002-05-05
Abstract
Abstract In a method of producing plasma fractions free of side-effects by purification and step-wise enrichment of plasma proteins in the presence of calcium-binding anticoagulants, also fast reactive (avid) antithrombin is present, wherein a concentration of the fast reacting (avid) antithrombin of 0.05 to 50 units per ml of the respective solution is maintained during all fractionation process steps.
Inventors
- 👤 Johann Eibl
- 👤 Fritz Elsinger
- 👤 Yendra Linnau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 19:47
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/56; A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86; G01N2333/00; G01N2333/81; G01N2333/8107; G01N2333/811; G01N2333/8121; G01N2333/8128; G01N2333/90; G01N2333/91; G01N2333/91045; G01N2333/91074; G01N2333/9108; G01N2333/91085; G01N2400/00; G01N2400/10; G01N2400/38; G01N2400/40; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
84 words
A method of producing plasma fractions free of side-effects, by purification and step-wise enrichment of plasma proteins, by a technique selected from the group consisting of filtration, cryoprecipitation, precipitation, adsorption, ultrafiltration, centrifugation and lyophilization, in the presence of calcium-binding anticoagulants, which method comprises the purification and enrichment of the plasma proteins, in the presence of fast reacting (avid) antithrombin, while maintaining a concentration of the fast reacting (avid) antithrombin of 0.05 to 50 units per ml of the respective solution during all fractionation-process steps.
Claim 2
Independent Claim
84 words
A method of producing plasma fractions free of side-effects, by purification and step-wise enrichment of plasma proteins, by a technique selected from the group consisting of filtration, cryoprecipitation, precipitation, adsorption, ultrafiltration, centrifugation and lyophilization, in the presence of calcium-binding anticoagulants, which method comprises the purification and enrichment of the plasma proteins, in the presence of fast reacting (avid) antithrombin, while maintaining a concentration of the fast reacting (avid) antithrombin of 0.05 to 50 units per ml of the respective solution during all fractionation-process steps.
Claim 3
Dependent Claim
33 words
A method as set forth in claim 1, wherein a concentration of the fast reacting (avid) antithrombin of 0.5 to 50 units of the same per ml of the respective solution is maintained.
Claim 4
Dependent Claim
20 words
A method as set forth in claim 1, wherein fast reacting (avid) antithrombin is formed in situ by adding inhibitor-cofactors.
Claim 5
Dependent Claim
14 words
A method as set forth in claim 3, wherein heparin is added as inhibitor-cofactor.
Claim 6
Dependent Claim
14 words
A method as set forth in claim 3, wherein heparinoids are added as inhibitor-cofactors.
Claim 7
Dependent Claim
38 words
A method as set forth in claim 1, comprising the steps of preforming fast reacting (avid) antithrombin so as to obtain a preformed antithrombin-cofactor complex, and adding said preformed antithrombin-cofactor complex in portions during the individual fractionation-process steps.
Claim 8
Dependent Claim
17 words
A method as set forth in claim 6, wherein said preformed antithrombin-cofactor complex is an antithrombin-III-cofactor complex.
Claim 9
Dependent Claim
15 words
A method as set forth in claim 1, wherein the calcium-binding anticoagulants are citrate ions.
Claim 10
Dependent Claim
17 words
A method as set forth in claim 1, wherein the plasma fractions are coagulation-factors obtained from plasma.
Claim 11
Dependent Claim
19 words
A method as set forth in claim 1, wherein the plasma fractions are immune globulin fractions obtained from plasma.
Claim 12
Dependent Claim
15 words
A method as set forth in claim 1, wherein the plasma fractions are C1-esterase inhibitors.
Claim 13
Dependent Claim
23 words
A method as set forth in claim 9 wherein the coagulation-factors are selected from the group consisting of factor-VIII-containing concentrates and factor-VIII-containing concentrates.
References Cited (Backward Citations)
DE2324717A1
Cited
US3803115A
Cited
FR2184898B1
Cited
US4137223A
Cited
GB2001528B
Cited
US4203891A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-13 | 1986-12-13 | 1987-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-13 | 1990-12-13 | 1991-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-13 | 1994-12-13 | 1995-06-14 | $7700.00 | Window Closed / Lapsed |