US4387106A
Expired / Lapsed
US
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Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas
Assignee: Wyeth Holdings LLC
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Filing: 1982-01-26
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Granted: 1983-06-07
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Expires: 2002-01-26
Abstract
Abstract Methods of treating atherosclerosis with di(aralkyl) ureas and di(aralkyl)thioureas, compositions thereof and processes for their preparation.
Inventors
- 👤 Vern G. De Vries
- 👤 Elwood E. Largis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 14:23
CPC Classifications
C; C07; C07C; C07C273/00; C07C273/18; C07C273/1809; C07C273/1818; C07C273/1827; A; A61; A61K; A61K31/00; A61K31/16; A61K31/17
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
220 words
A method of treating atherosclerosis, reducing the cholesterol ester content of the arterial wall, inhibiting atherosclerotic lesion development and/or treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula: ##STR6## wherein X represents at least one substituent selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkynyl, hydroxy, C 1 -C 4 alkoxy, phenoxy, mercapto, C 1 -C 4 alkylthio, amino, C 1 -C 4 alkylamino, di-(C 2 -C 4 alkyl)amino, halo, trihalomethyl, C 1 -C 4 alkanoyl, benzoyl, C 1 -C 4 alkanamido, C 1 -C 4 alkanesulfonyl, C 1 -C 4 alkanesulfinyl, benzenesulfonyl, toluenesulfonyl, nitro, cyano, carboxy, C 1 -C 4 carboalkoxy, carbamoyl, sulfamyl, methylenedioxy, phenyl, ortho-phenylene tolyl, benzyl, halobenzyl, methylbenzyl and the group ##STR7## Y is selected from the group consisting of oxygen and sulfur, and R is selected from the group consisting of C 7 -C 14 aralkyl, and C 7 -C 14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C 1 -C 10 alkyl, C 1 -C 10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C 1 -C 4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C 1 -C 4 carboalkoxy and nitro.
Claim 2
Independent Claim
220 words
A method of treating atherosclerosis, reducing the cholesterol ester content of the arterial wall, inhibiting atherosclerotic lesion development and/or treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula: ##STR6## wherein X represents at least one substituent selected from the group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 alkenyl, C 1 -C 4 alkynyl, hydroxy, C 1 -C 4 alkoxy, phenoxy, mercapto, C 1 -C 4 alkylthio, amino, C 1 -C 4 alkylamino, di-(C 2 -C 4 alkyl)amino, halo, trihalomethyl, C 1 -C 4 alkanoyl, benzoyl, C 1 -C 4 alkanamido, C 1 -C 4 alkanesulfonyl, C 1 -C 4 alkanesulfinyl, benzenesulfonyl, toluenesulfonyl, nitro, cyano, carboxy, C 1 -C 4 carboalkoxy, carbamoyl, sulfamyl, methylenedioxy, phenyl, ortho-phenylene tolyl, benzyl, halobenzyl, methylbenzyl and the group ##STR7## Y is selected from the group consisting of oxygen and sulfur, and R is selected from the group consisting of C 7 -C 14 aralkyl, and C 7 -C 14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C 1 -C 10 alkyl, C 1 -C 10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C 1 -C 4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C 1 -C 4 carboalkoxy and nitro.
Claim 3
Dependent Claim
11 words
A method as recited in claim 1, wherein Y is oxygen.
Claim 4
Dependent Claim
39 words
A method as recited in claim 2, wherein X represents at least one substituent selected from the group consisting of C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo, carboxy, C 1 -C 4 carboalkoxy, and benzyl.
Claim 5
Dependent Claim
15 words
A method as recited in claim 3, wherein R is C 7 -C 14 aralkyl.
Claim 6
Dependent Claim
11 words
A method as recited in claim 4, wherein R is benzyl.
Claim 7
Dependent Claim
27 words
A method as recited in claim 5, wherein X represents at least one substituent selected from the group consisting of C 1 -C 4 alkyl and halo.
Claim 8
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3-methylphenyl)urea.
Claim 9
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3-trifluoromethylphenyl)urea.
Claim 10
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3-chlorophenyl)urea.
Claim 11
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3,4-dichlorophenyl)urea.
Claim 12
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3,5-dichlorophenyl)urea.
Claim 13
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3-chloro-4-methylphenyl)urea.
Claim 14
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(2,4-dimethylphenyl)urea.
Claim 15
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(2-methylphenyl)urea.
Claim 16
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(4-methylphenyl)urea.
Claim 17
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(2,3-dimethylphenyl)urea.
Claim 18
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(2,5-dimethylphenyl)urea.
Claim 19
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(2,6-dimethylphenyl)urea.
Claim 20
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3,5-dimethylphenyl)urea.
Claim 21
Dependent Claim
12 words
The method as recited in claim 1, wherein the compound is 1,1-dibenzyl-3-(3,4-dimethylphenyl)urea.
Claim 22
Dependent Claim
30 words
A method of treating atherosclerosis in a mammal in need of such treatment which comprises administering to said mammal an antiatherosclerotic amount of a compound as recited in claim 1.
Claim 23
Dependent Claim
37 words
A method of reducing the cholesterol content of an arterial wall in a mammal in need of such treatment which comprises administering to said mammal a cholesterol ester-reducing amount of a compound as recited in claim 1.
Claim 24
Dependent Claim
34 words
A method of inhibiting atherosclerotic lesion development in a mammal in need of such treatment which comprises administering to said mammal an atherosclerotic lesion development-inhibiting amount of a compound as recited in claim 1.
Claim 25
Dependent Claim
31 words
A method of treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective lipid-altering amount of a compound as recited in claim 1.
References Cited (Backward Citations)
US4011340A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-06 | 1986-12-06 | 1987-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-06 | 1990-12-06 | 1991-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-06 | 1994-12-06 | 1995-06-07 | $7700.00 | Window Closed / Lapsed |