US4385116A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Demethylmacrocin and process for its production
Assignee: Eli Lilly and Co
•
Filing: 1980-07-15
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Granted: 1983-05-24
•
Expires: 2000-07-15
Abstract
Abstract 2'"-O-demethylmacrocin (DOMM) which has the formula: ##STR1## 20-dihydro-DOMM, 2'"-O-demethyllactenocin (DOML), 20-dihydro-DOML, specified acyl ester derivatives, and their acid addition salts are useful antibacterial agents.
Inventors
- 👤 Richard H. Baltz
- 👤 Gene M. Wild
- 👤 Eugene T. Seno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:35
CPC Classifications
C; C07; C07H; C07H17/00; C07H17/04; C07H17/08; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12R; C12R2001/00; C12R2001/01; C12R2001/465; C12R2001/54; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886; Y10S435/896
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
56 words
The method of producing 2'''-O-demethylmacrocin and 20-dihydro-2'''-O-demethylmacrocin which comprises cultivating bacteria having the identifying taxonomic characteristics of Streptomyces fradiae ATCC 31664 and capable of producing 2'''-O-demethylmacrocin in recoverable amounts in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
Claim 2
Independent Claim
56 words
The method of producing 2'''-O-demethylmacrocin and 20-dihydro-2'''-O-demethylmacrocin which comprises cultivating bacteria having the identifying taxonomic characteristics of Streptomyces fradiae ATCC 31664 and capable of producing 2'''-O-demethylmacrocin in recoverable amounts in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic fermentation conditions until a substantial amount of antibiotic activity is produced.
Claim 3
Dependent Claim
12 words
The method of claim 1 which comprises cultivating Streptomyces fradiae ATCC 31664.
Claim 4
Dependent Claim
15 words
The method of claim 1 or 2 which includes the additional step of isolating 2'''-O-demethylmacrocin.
Claim 5
Dependent Claim
15 words
The method of claim 1 or 2 which includes the additional step of isolating 20-dihydro-2'''-O-demethylmacrocin.
Claim 6
Dependent Claim
24 words
A biologically pure culture of bacteria having the identifying taxonomic characteristics of Streptomyces fradiae ATCC 31664 and capable of producing 2'''-O-demethylmacrocin in recoverable amounts.
Claim 7
Dependent Claim
24 words
A biologically pure culture of bacteria having the identifying taxonomic characteristics of Streptomyces fradiae ATCC 31664 and capable of producing 2'''-O-demethylmacrocin in recoverable amounts.
Claim 8
Dependent Claim
13 words
The culture of claim 5 wherein the microorganism is Streptomyces fradiae ATCC 31664.
References Cited (Backward Citations)
GB901273A
Cited
US3178341A
Cited
US3226759A
Cited
US3344024A
Cited
US3459853A
Cited
US4161523A
Cited
US4056616A
Cited
US4196280A
Cited
US4205163A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-05-23 | 1986-11-22 | 1987-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-05-23 | 1990-11-22 | 1991-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-05-23 | 1994-11-22 | 1995-05-24 | $7700.00 | Window Closed / Lapsed |