US4385066A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
Assignee: Beecham Group PLC
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Filing: 1981-05-13
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Granted: 1983-05-24
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Expires: 2001-05-13
Abstract
Abstract Compounds of formula (II): ##STR1## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, wherein R 1 and R 2 , which may be the same or different, are each of a hydrogen atom or a methyl group, n is 1, 2 or 3, and Z is a C 1-6 alkyl or C 1-6 alkoxy group, or a halogen or hydrogen atom are useful in treating obesity and/or hyperglycaemia and/or inflammation in mammals.
Inventors
- 👤 Anthony T. Ainsworth
- 👤 David G. Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 06:41
CPC Classifications
C; C07; C07C; C07C229/00; C07C229/38; A; A61; A61P; A61P29/00; A61P3/00; A61P3/08
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
60 words
A compound of formula (II): ##STR20## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, in which R 1 and R 2 , which may be the same or different, are each hydrogen or methyl, n is 1, 2 or 3, and Z is a C 1-6 alkyl or C 1-6 alkoxy or halogen or hydrogen.
Claim 2
Dependent Claim
60 words
A compound of formula (II): ##STR20## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, in which R 1 and R 2 , which may be the same or different, are each hydrogen or methyl, n is 1, 2 or 3, and Z is a C 1-6 alkyl or C 1-6 alkoxy or halogen or hydrogen.
Claim 3
Dependent Claim
45 words
A compound of formula (III): ##STR21## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, wherein R 1 and R 2 , which may be the same or different, are each hydrogen or methyl and n is 1, 2 or 3.
Claim 4
Dependent Claim
45 words
A compound of formula (III): ##STR21## or a pharmaceutically acceptable salt, lower alkyl or aralkyl ester or amide thereof, wherein R 1 and R 2 , which may be the same or different, are each hydrogen or methyl and n is 1, 2 or 3.
Claim 5
Dependent Claim
17 words
A compound according to claim 1, in which R 1 is hydrogen and R 2 is methyl.
Claim 6
Dependent Claim
11 words
A compound according to claim 1, in which n is 1.
Claim 7
Dependent Claim
20 words
A compound according to claim 1, in which Z is methyl, ethyl, methoxy or ethoxy, or is chlorine or hydrogen.
Claim 8
Dependent Claim
18 words
A compound according to claim 1, in which the ester is the methyl, ethyl, propyl or benzyl ester.
Claim 9
Dependent Claim
9 words
The compound according to claim 1, which is N-(2-(4-carbomethoxyphenyl)-1-methylethyl)-2-hydroxy-2-(3-trifluoromethylphenyl)ethanamine.
Claim 10
Dependent Claim
36 words
A pharmaceutical composition for the treatment of obesity or hyperglycaemia, comprising an effective amount of a compound or a pharmaceutically acceptable salt, ester or amide thereof according to claim 1, together with a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
11 words
A pharmaceutical composition according to claim 8, in unit dosage form.
Claim 12
Dependent Claim
23 words
A composition according to claim 9, in which each unit dose contains from 0.1 to 500 mg of said compound of formula (II).
Claim 13
Dependent Claim
37 words
A method of treating obesity in human or non-human animals, which comprises administering an effective, non-toxic amount of a compound or a pharmaceutically acceptable salt, ester or amide thereof according to claim 1 to the obese animals.
Claim 14
Dependent Claim
33 words
A method of treating hyperglycaemia, in humans, which comprises administering an effective, non-toxic amount of a compound or a pharmaceutically acceptable salt, ester or amide thereof according to claim 1 to hyperglycaemic humans.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-05-23 | 1986-11-22 | 1987-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-05-23 | 1990-11-22 | 1991-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-05-23 | 1994-11-22 | 1995-05-24 | $7700.00 | Window Closed / Lapsed |