Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
250 words
A compound of the formula ##STR186## or salts thereof wherein R is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R 1 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl; R 2 is hydrogen or ##STR187## R 3 is ##STR188## R 4 is hydrogen, lower alkyl or arylalkyl; R 5 and R 6 are each independently selected as --OCH 3 or --OCH 2 CH 3 or are combined as --OCH 2 --CH 2 --O-- or --O--(CH 2 ) 3 --O--; R 7 and R 8 are each independently selected as hydrogen, lower alkyl or are combined as --(CH 2 ) 4 --, --(CH 2 ) 5 -- or --CH 2 CH 2 --O--CH 2 CH 2 --; R 9 is hydrogen, lower alkyl, ##STR189## m is an integer from 0 to 7; p is an integer from 1 to 3 with the proviso that when p is 1, R 2 is -(lower alkyl) ##STR190## AA n is an amino acid chain or from one to three amino acids; n is 1 or 1, 2 or 1, 2, 3; when p is 1, AA n is AA 1 ; when p is 2, AA n is AA 1 --AA 2 ; when p is 3, AA n is AA 1 --AA 2 --AA 3 ; AA 1 is glycine or alanine; AA 2 is glycine or alanine; AA 3 is leucine, glutamine or isoleucine, and physiologically acceptable salts thereof.
Claim 2
Dependent Claim
250 words
A compound of the formula ##STR186## or salts thereof wherein R is hydrogen, alkanoyl of 2 to 10 carbon atoms or arylcarbonyl; R 1 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl or arylalkyl; R 2 is hydrogen or ##STR187## R 3 is ##STR188## R 4 is hydrogen, lower alkyl or arylalkyl; R 5 and R 6 are each independently selected as --OCH 3 or --OCH 2 CH 3 or are combined as --OCH 2 --CH 2 --O-- or --O--(CH 2 ) 3 --O--; R 7 and R 8 are each independently selected as hydrogen, lower alkyl or are combined as --(CH 2 ) 4 --, --(CH 2 ) 5 -- or --CH 2 CH 2 --O--CH 2 CH 2 --; R 9 is hydrogen, lower alkyl, ##STR189## m is an integer from 0 to 7; p is an integer from 1 to 3 with the proviso that when p is 1, R 2 is -(lower alkyl) ##STR190## AA n is an amino acid chain or from one to three amino acids; n is 1 or 1, 2 or 1, 2, 3; when p is 1, AA n is AA 1 ; when p is 2, AA n is AA 1 --AA 2 ; when p is 3, AA n is AA 1 --AA 2 --AA 3 ; AA 1 is glycine or alanine; AA 2 is glycine or alanine; AA 3 is leucine, glutamine or isoleucine, and physiologically acceptable salts thereof.
Claim 3
Dependent Claim
19 words
A compound of claim 1 wherein R is hydrogen, R 3 is ##STR191## and m is 0 to 3.
Claim 4
Dependent Claim
9 words
A compound of claim 2 wherein n is 3.
Claim 5
Dependent Claim
9 words
A compound of claim 3 having the name N-[N-[[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]-L-alanyl]glycyl]-L-leucyl]-L-arginine.
Claim 6
Dependent Claim
13 words
The compound of claim 1 having the name (±)-N 2 -[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycyl]-L-argininamide, monoacetate salt.
Claim 7
Dependent Claim
11 words
The compound of claim 1 having the name N 2 -[N-[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycyl]glycyl]-L-arginine.
Claim 8
Dependent Claim
11 words
The compound of claim 1 having the name N 2 -[N-[N-[N-[2-(mercaptomethyl)-4-methyl-1-oxopentyl]glycyl]glycyl]-L-leucyl]-L-arginine.
Claim 9
Dependent Claim
26 words
A pharmaceutical composition for reducing the adverse effects of mammalian collagenase which comprises a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 10
Dependent Claim
34 words
A method for reducing the adverse effects of mammalian collagenase in a mammalian host in need thereof, which comprises administering to said mammal an effective amount of a compound as defined in claim 1.
Claim 11
Dependent Claim
24 words
A method for treating rheumatoid arthritis in a mammalian host, which comprises administering an effective amount of a compound as defined in claim 1.