US4381292A
Expired / Lapsed
US
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Anti-human T-lymphocyte monoclonal antibody
Assignee: Leland Stanford Junior University
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Filing: 1980-11-14
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Granted: 1983-04-26
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Expires: 2000-11-14
Abstract
Abstract Mammalian monoclonal antibodies specific for an antigen diagnostic for thymocytes, normal peripheral T cells and some null cells. The antibodies which distinguish among subpopulations of T cells, find use in assays, cell sorting, and immunosupression.
Inventors
- 👤 Charles P. Bieber
- 👤 Frank D. Howard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 02:15
CPC Classifications
C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; G01N33/56966; G01N33/56972; A; A61; A61K; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/808
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
25 words
Mammalian monoclonal antibodies specific for the lymphocyte antigen Leu-5, specifically binding to thymocytes and E-rosette forming peripheral blood lymphocytes and inhibiting human thymocyte rosette formation.
Claim 2
Dependent Claim
25 words
Mammalian monoclonal antibodies specific for the lymphocyte antigen Leu-5, specifically binding to thymocytes and E-rosette forming peripheral blood lymphocytes and inhibiting human thymocyte rosette formation.
Claim 3
Dependent Claim
11 words
Antibodies according to claim 1, wherein said mammal is a mouse.
Claim 4
Dependent Claim
37 words
Mammalian monoclonal antibodies specific for the lymphocyte surface antigen Leu-5 having a label providing a detectible signal, specifically binding to human thymocytes and human peripheral blood lymphocytes which form E-rosettes and inhibiting E-rosette formation of human thymocytes.
Claim 5
Dependent Claim
37 words
Mammalian monoclonal antibodies specific for the lymphocyte surface antigen Leu-5 having a label providing a detectible signal, specifically binding to human thymocytes and human peripheral blood lymphocytes which form E-rosettes and inhibiting E-rosette formation of human thymocytes.
Claim 6
Dependent Claim
30 words
Mammalian monoclonal antibodies according to claim 3, wherein said label is a member of the group consisting of a radioactive isotope, enzyme, fluorescent compound, chemiluminescent compound, ferromagnetic atom, or particle.
Claim 7
Dependent Claim
15 words
The mammalian monoclonal antibody according to claim 4, wherein said label is a radioactive isotope.
Claim 8
Dependent Claim
15 words
A mammalian monoclonal antibody according to claim 4, wherein said label is a fluorescent molecule.
Claim 9
Dependent Claim
56 words
A method for determining the presence of a cell suspected of containing a Leu-5 surface antigen, said method comprises combining a sample suspected of containing said cell having said Leu-5 surface antigen with mammalian monoclonal antibody according to claim 3; and detecting the presence of said Leu-5 by means of said signal provided by said label.
Claim 10
Dependent Claim
13 words
A method according to claim 7, wherein said label is a radioactive isotope.
Claim 11
Dependent Claim
36 words
A method for supressing the immunological response by a mammalian host to an immunogen which comprises introducing into said host a sufficient amount of mammalian monoclonal antibody according to claim 1 to suppress said immunological response.
References Cited (Backward Citations)
US4196265A
Cited
EP0018794A2
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-25 | 1986-10-25 | 1987-04-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-25 | 1990-10-25 | 1991-04-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-25 | 1994-10-25 | 1995-04-26 | $7700.00 | Window Closed / Lapsed |