US4380581A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Istamycins and streptomyces culture for the production thereof
Assignee: Microbial Chemistry Research Foundation
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Filing: 1981-02-05
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Granted: 1983-04-19
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Expires: 2001-02-05
Abstract
Abstract Four new antibiotics which are denominated istamycin A, istamycin B, istamycin Ao and istamycin Bo, and which are useful as antibacterial agents, are produced by fermentation of a new microorganism, Streptomyces tenjimariensis.
Inventors
- 👤 Hamao Umezawa
- 👤 Yoshiro Okami
- 👤 Shinichi Kondo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 20:09
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/22; C07H15/222; C07H15/224; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P19/00; C12P19/44; C12P19/46; C12P19/48; C12R; C12R2001/00; C12R2001/01; C12R2001/465; Y; Y10; Y10S; Y10S435/00; Y10S435/8215; Y10S435/822; Y10S435/886
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
58 words
The process for the production of the antibiotic, istamycin complex, which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin is produced and accumulated in the culture medium.
Claim 2
Dependent Claim
58 words
The process for the production of the antibiotic, istamycin complex, which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin is produced and accumulated in the culture medium.
Claim 3
Dependent Claim
19 words
The process of claim 1 which comprises the additional step of recovering the istamycin complex from the culture medium.
Claim 4
Dependent Claim
55 words
The process of producing istamycin A which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin A is produced and accumulated in the culture medium.
Claim 5
Dependent Claim
55 words
The process of producing istamycin A which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin A is produced and accumulated in the culture medium.
Claim 6
Dependent Claim
55 words
The process of producing istamycin B which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin B is produced and accumulated in the culture medium.
Claim 7
Dependent Claim
55 words
The process of producing istamycin B which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin B is produced and accumulated in the culture medium.
Claim 8
Dependent Claim
57 words
The process of producing istamycin A o which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin A o is produced and accumulated in the culture medium.
Claim 9
Dependent Claim
57 words
The process of producing istamycin A o which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin A o is produced and accumulated in the culture medium.
Claim 10
Dependent Claim
57 words
The process of producing istamycin B o which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin B o is produced and accumulated in the culture medium.
Claim 11
Dependent Claim
57 words
The process of producing istamycin B o which comprises cultivating a microorganism having the identifying characteristics of Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603, under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial amount of istamycin B o is produced and accumulated in the culture medium.
Claim 12
Dependent Claim
28 words
The process of claim 3, 4, 5 or 6 which comprises the additional step of isolating istamycin A, istamycin B, istamycin A o or istamycin B o .
Claim 13
Dependent Claim
46 words
A biologically pure culture of the microorganism, Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603 which is capable of producing the antibiotic, istamycin complex, in a recoverable quantity upon cultivation in a culture medium containing assimilable sources of carbon and nitrogen under aerobic conditions.
Claim 14
Dependent Claim
46 words
A biologically pure culture of the microorganism, Streptomyces tenjimariensis SS-939, identified as FERM-P 4932 or ATCC 31603 which is capable of producing the antibiotic, istamycin complex, in a recoverable quantity upon cultivation in a culture medium containing assimilable sources of carbon and nitrogen under aerobic conditions.
Claim 15
Dependent Claim
22 words
The process of claim 7 which includes the additional step of hydrolyzing istamycin A under alkaline conditions to istamycin A o .
Claim 16
Dependent Claim
22 words
The process of claim 7 which includes the additional step of hydrolyzing istamycin B under alkaline conditions to istamycin B o .
References Cited (Backward Citations)
US4216308A
Cited
US4205070A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-18 | 1986-10-18 | 1987-04-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-18 | 1990-10-18 | 1991-04-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-18 | 1994-10-18 | 1995-04-19 | $7700.00 | Window Closed / Lapsed |