Trialkylsilicon-containing phenylcycloalkane analgesics
Abstract
Abstract A compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: G is hydroxymethylene or carbonyl; R is hydrogen or alkanoyl having from one to seven carbon atoms; R 1 and R 2 are each methyl or ethyl; R 3 is an alkyl of from five to seven carbon atoms; m is 0 or 1; and n is 1, 2 or 3. A preferred compound is one in which m is zero, n is one or G is hydroxymethylene. Also preferred are compounds in which R 1 and R 2 are methyl. Additional preferred compounds include those where R is hydrogen or acetyl. A preferred compound is Z-3-(4'-(dimethyl-n-hexylsilyl)-2'-hydroxyphenyl)cyclohexanol. The invention further comprises pharmaceutical compositions containing these compounds. In accordance with the present invention, these compounds when administered in an effective amount to mammals are useful as CNS agents including analgesics, tranquilizers, sedatives, anticonvulsants, antidiarrheals, antiemetics and antianxiety agents.
Inventors
- 👤 Lawrence S. Melvin, Jr.
- 👤 Michael R. Johnson
Bibliographic Details
Claims Analysis
Total Claims: 12References Cited (Backward Citations)
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