US4378353A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Novel C-076 compounds
Assignee: Merck and Co Inc
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Filing: 1981-02-17
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Granted: 1983-03-29
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Expires: 2001-02-17
Abstract
Abstract There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Inventors
- 👤 Robert T. Goegelman
- 👤 Vincent P. Gullo
- 👤 Louis Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:45
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/12; C07D493/20; A; A61; A61P; A61P31/00; A61P31/04; C07H; C07H19/00; C07H19/01; C12; C12N; C12N1/00; C12N1/20; C12N1/205; C12P; C12P17/00; C12P17/18; C12P17/181; C12P19/00; C12P19/44; C12P19/60; C12P19/62; C12P19/623; C12R; C12R2001/00; C12R2001/01; C12R2001/465
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
50 words
A compound having the formula ##STR5## wherein: (a.) R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is methyl; (b.) R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is hydrogen; and (c.) R 1 is α-L-oleandrosyl-α-L-oleandrosyl; R 2 is sec-butyl and R 3 is hydrogen.
Claim 2
Dependent Claim
50 words
A compound having the formula ##STR5## wherein: (a.) R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is methyl; (b.) R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is hydrogen; and (c.) R 1 is α-L-oleandrosyl-α-L-oleandrosyl; R 2 is sec-butyl and R 3 is hydrogen.
Claim 3
Dependent Claim
19 words
The compound of claim 1 wherein R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is methyl.
Claim 4
Dependent Claim
19 words
The compound of claim 1 wherein R 1 is α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is hydrogen.
Claim 5
Dependent Claim
19 words
The compound of claim 1 wherein R 1 is α-L-oleandrosyl-α-L-oleandrosyl; R 2 is sec-butyl and R 3 is hydrogen.
Claim 6
Dependent Claim
38 words
A compound having the formula: ##STR6## wherein: (a.) R 2 is isopropyl; and R 3 is methoxy; (b.) R 2 is sec-butyl; and R 3 is keto; and (c.) R 2 is iso-propyl; and R 3 is keto.
Claim 7
Dependent Claim
38 words
A compound having the formula: ##STR6## wherein: (a.) R 2 is isopropyl; and R 3 is methoxy; (b.) R 2 is sec-butyl; and R 3 is keto; and (c.) R 2 is iso-propyl; and R 3 is keto.
Claim 8
Dependent Claim
15 words
The compound of claim 5 wherein R 2 is iso-propyl; and R 3 is methoxy.
Claim 9
Dependent Claim
15 words
The compound of claim 5 wherein R 2 is sec-butyl; and R 3 is keto.
Claim 10
Dependent Claim
15 words
The compound of claim 5 wherein R 2 is iso-propyl and R 3 is keto.
Claim 11
Dependent Claim
20 words
A compound having the formula: ##STR7## wherein R 1 is α-L-oleandrosyl-α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is hydrogen.
Claim 12
Dependent Claim
20 words
A compound having the formula: ##STR7## wherein R 1 is α-L-oleandrosyl-α-L-oleandrosyl; R 2 is sec-butyl; and R 3 is hydrogen.
Claim 13
Independent Claim
31 words
A method for the treatment of parasite infections in animals infected with parasites, which comprises administering to said animal an effective amount of a compound of claims 1, 5 or 9.
Claim 14
Dependent Claim
27 words
A composition useful for the treatment of parasite infections which comprises an inert carrier and an effective amount of a compound of claims 1, 5 or 9.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1986-03-28 | 1986-09-27 | 1987-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-03-28 | 1990-09-27 | 1991-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-03-28 | 1994-09-27 | 1995-03-29 | $7700.00 | Window Closed / Lapsed |