US4376782A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Complexes of square planar platinum II compounds and N-methyl glucamine
Assignee: Research Corp
•
Filing: 1980-05-21
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Granted: 1983-03-15
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Expires: 2000-05-21
Abstract
Abstract Complexes or salts of square planar platinum(II) compounds and N-methyl glucamine, prepared by reacting a platinum(II) compound with N-methyl glucamine in an aqueous medium, are effective anti-tumor agents.
Inventors
- 👤 John Turkevich
- 👤 Joseph H. Burchenal
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:14
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
27 words
A cis-complex or -salt prepared by reacting a cis-square planar platinum compound with N-methyl-glucamine wherein two moles of N-methyl-glucamine are reacted with each mole of platinum compound.
Claim 2
Dependent Claim
27 words
A cis-complex or -salt prepared by reacting a cis-square planar platinum compound with N-methyl-glucamine wherein two moles of N-methyl-glucamine are reacted with each mole of platinum compound.
Claim 3
Dependent Claim
18 words
The complex or salt of claim 1 prepared by reacting said platinum compound and N-methyl-glucamine in aqueous solution.
Claim 4
Dependent Claim
14 words
The complex or salt of claim 1 wherein said platinum compound is a haloplatinate.
Claim 5
Dependent Claim
14 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichlorodiammine platinum-II.
Claim 6
Dependent Claim
14 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichloro-1,2-diaminocyclohexane platinum-II.
Claim 7
Dependent Claim
13 words
The complex or salt of claim 1 wherein said platinum compound is cis-malonato-1,2-diaminocyclohexaneplatinum-II.
Claim 8
Dependent Claim
13 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichloro-1,2-diaminocyclopentaneplatinum-II.
Claim 9
Dependent Claim
13 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichloro-1,2-diaminocycloheptaneplatinum-II.
Claim 10
Dependent Claim
13 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichloro-ethylenediamine-platinum-II.
Claim 11
Dependent Claim
15 words
The complex or salt of claim 1 wherein said platinum compound is cis-dichloro-bis (isopropylamino) platinum-II.
Claim 12
Independent Claim
35 words
A method comprising reacting a cis-square platinum compound, and for each mole thereof two moles of N-methyl-glucamine in an aqueous medium and recovering the cis-complex or -salt of said platinum compound and N-methyl-glucamine formed therein.
Claim 13
Independent Claim
35 words
A method comprising reacting a cis-square platinum compound, and for each mole thereof two moles of N-methyl-glucamine in an aqueous medium and recovering the cis-complex or -salt of said platinum compound and N-methyl-glucamine formed therein.
Claim 14
Dependent Claim
12 words
The method of claim 11 wherein said platinum compound is a haloplatinate.
Claim 15
Dependent Claim
12 words
The method of claim 11 wherein said platinum compound is cis-dichlorodiamine platinum-II.
Claim 16
Dependent Claim
12 words
The method of claim 11 wherein said platinum compound is cis-dichloro-1,2-diaminocyclohexane platinum-II.
Claim 17
Dependent Claim
11 words
The method of claim 11 wherein said platinum compound is cis-malonato-1,2-diaminocyclohexane-platinum-II.
Claim 18
Dependent Claim
11 words
The method of claim 11 wherein said platinum compound is cis-dichloro-1,2-diaminocyclopentane-platinum-II.
Claim 19
Dependent Claim
11 words
The method of claim 11 wherein said platinum compound is cis-dichloro-1,2-diaminocycloheptane-platinum-II.
Claim 20
Dependent Claim
11 words
The method of claim 11 wherein said platinum compound is cis-dichloro-ethylene-diamine-platinum-II.
Claim 21
Dependent Claim
12 words
The method of claim 11 wherein said platinum compound is cis-dichloro-bis(isopropylamine) platinum-II.
Claim 22
Dependent Claim
49 words
A pharmaceutical composition in unit-dosage form for the treatment of animal malignant tumor cells sensitive to a complex or salt of claim 1 consisting essentially of an effective amount of said complex or salt sufficient to cause regression of said animal tumor cells and a pharmaceutically acceptable carrier therefor.
Claim 23
Dependent Claim
44 words
A method of treating animal malignant tumor cells sensitive to a complex or salt of claim 1 comprising administering to an animal afflicted with said tumor cells an effective amount of said complex or salt sufficient to cause regression of the animal tumor cells.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-03-14 | 1986-09-13 | 1987-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-03-14 | 1990-09-13 | 1991-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-03-14 | 1994-09-13 | 1995-03-15 | $7700.00 | Window Closed / Lapsed |