US4376781A
Expired / Lapsed
US
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Pharmaceutical compositions
Assignee: Indena SpA
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Filing: 1978-02-27
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Granted: 1983-03-15
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Expires: 1998-02-27
Abstract
Abstract Valuable pharmaceutical properties of flavylium salts are described, including anti-inflammatory, vaso-protective, hypolipaemic, hypocholesterolaemic and hypoglycaemic activity. The use of flavylium salts as drugs and the production of pharmaceutical compositions containing them is particularly referred to.
Inventors
- 👤 Andrea Lietti
- 👤 Attilio Bonati
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 23:12
CPC Classifications
C; C07; C07D; C07D311/00; C07D311/02; C07D311/04; C07D311/58
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
116 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR15## B is selected from the group consisting of ##STR16## and X - is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier, with the proviso that where the composition consists of a solution of said flavylium salt, said solution also contains at least one pharmaceutically acceptable additive selected from the group consisting of preservatives and buffering, thickening, suspending, stabilizing, wetting, emulsifying, coloring and flavoring agents.
Claim 2
Dependent Claim
116 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR15## B is selected from the group consisting of ##STR16## and X - is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier, with the proviso that where the composition consists of a solution of said flavylium salt, said solution also contains at least one pharmaceutically acceptable additive selected from the group consisting of preservatives and buffering, thickening, suspending, stabilizing, wetting, emulsifying, coloring and flavoring agents.
Claim 3
Dependent Claim
108 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR17## B is selected from the group consisting of ##STR18## and X - is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier selected from the group consisting of carboxy vinyl polymers, propylene glycol, cetyl alcohol, saturated vegetable triglycerides, fatty acid esters, triethanol amine, glycerol, starch, sorbitol, bentonite, carboxymethyl cellulose, lauryl sulfate, dicalcium phosphate, powdered silica, and lecithin.
Claim 4
Dependent Claim
108 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR17## B is selected from the group consisting of ##STR18## and X - is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier selected from the group consisting of carboxy vinyl polymers, propylene glycol, cetyl alcohol, saturated vegetable triglycerides, fatty acid esters, triethanol amine, glycerol, starch, sorbitol, bentonite, carboxymethyl cellulose, lauryl sulfate, dicalcium phosphate, powdered silica, and lecithin.
Claim 5
Dependent Claim
79 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR19## B is selected from the group consisting of ##STR20## and X - is a pharmaceutically acceptable anion, and a combination of at least two different pharmaceutically acceptable diluents or carriers.
Claim 6
Dependent Claim
79 words
A pharmaceutical composition comprising, as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure A.sup.+ --B X.sup.- containing at least one hydroxy or methoxy substituent and wherein A + is selected from the group consisting of ##STR19## B is selected from the group consisting of ##STR20## and X - is a pharmaceutically acceptable anion, and a combination of at least two different pharmaceutically acceptable diluents or carriers.
Claim 7
Dependent Claim
26 words
A pharmaceutical composition according to claim 1 in which the flavylium salt is selected from the group consisting of cyanidine, peonidine, delphinidine, petunidine, malvidine and pelargonidine.
Claim 8
Dependent Claim
30 words
A pharmaceutical composition according to claim 1 in which the active ingredient is selected from the group consisting of 4'-hydroxyflavylium, 3,7-dihydroxyflavylium, 3-hydroxyflavylium, 3,4'-dihydroxyflavylium, 3,5,7-trihydroxy-3',4',5'-trimethoxyflavylium, 3,7,4'-trihydroxyflavylium, 3,5,7-trihydroxyflavylium, 3,4-dihydroxyflavylium and 5,7-dihydroxyflavylium salts.
Claim 9
Dependent Claim
24 words
A pharmaceutical composition according to claim 1 wherein X - is selected from the group consisting of chloride, sulphate, phosphate, acetate and hydroxyl ions.
Claim 10
Dependent Claim
23 words
A composition according to claim 1 and further containing a preservative or a buffering, thickening, suspending, stabilizing, wetting, emulsifying, colouring or flavoring agent.
Claim 11
Dependent Claim
48 words
A composition according to claim 1 wherein said diluent or carrier is selected from the group consisting of carboxy vinyl polymers, propylene, glycol, ethyl alcohol, water, cetyl alcohol, saturated vegetable triglycerides, fatty acid esters, triethanolamine, glycerol, starch, sorbitol, bentonite, carboxymethyl cellulose, laurylsulphate, dicalcium phosphate, powdered silica and lecithin.
Claim 12
Dependent Claim
22 words
A composition according to claim 1 wherein said diluent or carrier comprises a combination of at least two different diluents or carriers.
Claim 13
Dependent Claim
14 words
A composition according to claim 1 containing more than one of said flavylium salts.
Claim 14
Dependent Claim
16 words
A composition according to claim 1 in a form suitable for parenteral, oral or topical administration.
Claim 15
Dependent Claim
12 words
A composition according to claim 1 in the form of a suppository.
Claim 16
Dependent Claim
12 words
A composition according to claim 11 in the form of a dentifrice.
Claim 17
Dependent Claim
14 words
A composition according to claim 1 in the form of a shaped dosage unit.
Claim 18
Dependent Claim
16 words
A composition according to claim 1 containing at least 0.2 wt % of said flavylium salt.
Claim 19
Dependent Claim
17 words
A composition according to claim 1 containing from 1 to 50 wt % of said flavylium salt.
Claim 20
Dependent Claim
16 words
A composition according to claim 15 containing at least 5 wt % of said flavylium salt.
Claim 21
Dependent Claim
31 words
A method of elliciting a hypolipaemic, hypocholesterolaemic or hypoglycaemic response in a subject, which comprises administering to the subject an effective dose of a flavylium salt as defined in claim 1.
Claim 22
Dependent Claim
28 words
A method according to claim 18 in which the flavylium salt is administered in combination with a pharmaceutically acceptable diluent or carrier, in the form of a composition.
Claim 23
Dependent Claim
26 words
A method according to claim 18 in which the flavylium salt is administered as a treatment of disorders caused by impairment of lipidic or glycidic metabolism.
Claim 24
Dependent Claim
23 words
A method according to claim 18 in which said effective dose is from 1 to 100 mg/kg per day of said flavylium salt.
Claim 25
Dependent Claim
24 words
A method according to claim 21 in which said effective daily dose is from 5 to 50 mg/kg per day of said flavylium salt.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-03-14 | 1986-09-13 | 1987-03-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-03-14 | 1990-09-13 | 1991-03-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-03-14 | 1994-09-13 | 1995-03-15 | $7700.00 | Window Closed / Lapsed |