Stable nonaqueous solution of tetracycline salt

Claim 1

A stable nonaqueous solution of tetracycline hydrochloride consisting essentially of a mixture of 0.25 to 2 percent tetracycline hydrochloride, 41 to 88 percent of a nonaqueous diluent material selected from the class consisting of glyceryl triacetate, diisopropyl sebacate, diisopropyl adipate, isopropyl palmitate, isopropyl myristate, lauryl lactate, linear alcohol lactate, decyl oleate, isodecyl oleate, 2-ethylhexyl palmitate, isopropyl linoleate, acetylated monoglyceride, acetyl tributyl citrate, acetyl triethyl citrate, tricyclo hexyl citrate, butyl myristate, promyristyl propionate, dibutyl sebacate, dioctyl adipate, dioctyl succinate, isobutyl acetate, acetamide, methyl acetamide, polydimethyl cyclosiloxane, hexamethyl disiloxane, and fractionated triglycerides of coconut oil origin, 4 to 40 percent of a nonaqueous solvent selected from the class consisting of ethanol, methanol, isopropanol, butanol, N-methyl-2-pyrrolidone and acetone, 0.3 to 20 percent nonaqueous nonionic solubilizer selected from the class consisting of polyethylene glycols, methoxy polyethylene glycols, polysorbates, ethylene oxide-propylene oxide block copolymers, sorbitan esters and glycerin, 0 to 6 percent nonaqueous anionic solubilizer selected from the class consisting of monovalent or divalent salts of dialkyl sulfosuccinates, acyl lactates and aryl sulfonates, and 0 to 0.75 percent antioxidant selected from the class consisting of ascorbyl palmitate, ascorbic acid, propyl gallate, butylated hydroxytoluene, butylated hydroxyanisole, tertiary butyl hydroquinone, and d-beta, gamma and delta isomers of tocopherol, said percent values being on a weight/weight basis based on the entire solution weight.