US4374838A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines
Assignee: Merck and Co Inc
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Filing: 1981-10-22
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Granted: 1983-02-22
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Expires: 2001-10-22
Abstract
Abstract Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.
Inventors
- 👤 Paul S. Anderson
- 👤 Marcia E. Christy
- 👤 Ben E. Evans
- 👤 David C. Remy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 21:19
CPC Classifications
C; C07; C07D; C07D451/00; C07D451/14; C07C; C07C1/00; C07C1/20; C07C1/24; C07C29/00; C07C29/132; C07C29/136; C07C29/143; C07C29/17; C07C29/36; C07C29/38; C07C29/40; C07C45/00; C07C45/56; C07C45/57; C07C45/59; C07C45/61; C07C45/62; C07C45/67; C07C45/673; C07C45/68; C07D317/00; C07D317/08; C07D317/72; C07D487/00; C07D487/02; C07D487/08; C07C2603/00; C07C2603/02; C07C2603/04; C07C2603/36
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
69 words
A method of treating anxiety, depression, muscle spasm, convulsions, mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders comprising administering to a patient in need of such treatment an effective amount of a compound of structural formula: ##STR144## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C 1-3 alkyl; R 2 is C 1-3 alkyl, and R 1 , R 3 and R 4 are all hydrogen.
Claim 2
Independent Claim
69 words
A method of treating anxiety, depression, muscle spasm, convulsions, mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders comprising administering to a patient in need of such treatment an effective amount of a compound of structural formula: ##STR144## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C 1-3 alkyl; R 2 is C 1-3 alkyl, and R 1 , R 3 and R 4 are all hydrogen.
Claim 3
Dependent Claim
16 words
The method of claim 1 wherein the compound is 12-methyl-5,6,7,12-tetrahydrodibenzo[a,d]cycloocten-6,12-imine or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
71 words
A pharmaceutical composition useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant, or in the treatment of mixed anxiety-depression, minimal brain dysfunction or extrapyramidal disorders comprising a pharmaceutical carrier and an effective amount of a compound of structural formula: ##STR145## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C 1-3 alkyl; R 2 is C 1-3 alkyl, and R 1 , R 3 and R 4 are all hydrogen.
Claim 5
Dependent Claim
71 words
A pharmaceutical composition useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant, or in the treatment of mixed anxiety-depression, minimal brain dysfunction or extrapyramidal disorders comprising a pharmaceutical carrier and an effective amount of a compound of structural formula: ##STR145## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C 1-3 alkyl; R 2 is C 1-3 alkyl, and R 1 , R 3 and R 4 are all hydrogen.
Claim 6
Dependent Claim
16 words
The composition of claim 3, wherein the compound is 12-methyl-5,6,7,12-tetrahydrodibenzo[a,d]cycloocten-6,12-imine or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-21 | 1986-08-23 | 1987-02-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-21 | 1990-08-23 | 1991-02-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-21 | 1994-08-23 | 1995-02-22 | $7700.00 | Window Closed / Lapsed |