US4374248A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3,4-Disubstituted-1,2,5-thiadiazole-1-oxide compounds
Assignee: Bristol Myers Co
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Filing: 1981-06-23
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Granted: 1983-02-15
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Expires: 2001-06-23
Abstract
Abstract Histamine H2-antagonists of the formula <IMAGE> I wherein p is 1 or 2; R1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anit-ulcer agents. Intermediates and processes for their preparation are disclosed.
Inventors
- 👤 Ronnie R. Crenshaw
- 👤 Aldo A. Algieri
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:49
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D213/24; C07D213/36; C07D213/38; C07D271/00; C07D271/02; C07D271/06; C07D271/08; C07D271/10; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/28; C07D277/32; C07D277/38; C07D277/40; C07D277/42; C07D277/44; C07D277/48; C07D277/56; C07D285/00; C07D285/01; C07D285/02; C07D285/04; C07D285/10; C07D307/00; C07D307/02; C07D307/34; C07D307/38; C07D307/52; C07D417/00; C07D417/02; C07D417/12
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
33 words
A compound of the formula ##STR60## wherein each R 7 is halogen, (lower)alkoxy or (lower)alkylthio, or phenoxy or phenylthio which may contain 1 or 2 substituents selected from halogen, (lower)alkyl, (lower)alkoxy and nitro.
Claim 2
Dependent Claim
33 words
A compound of the formula ##STR60## wherein each R 7 is halogen, (lower)alkoxy or (lower)alkylthio, or phenoxy or phenylthio which may contain 1 or 2 substituents selected from halogen, (lower)alkyl, (lower)alkoxy and nitro.
Claim 3
Dependent Claim
12 words
A compound of claim 1 in which each R 7 is (lower)alkoxy.
Claim 4
Dependent Claim
2 words
3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide.
Claim 5
Dependent Claim
2 words
3,4-Dimethoxy-1,2,5-thiadiazole 1-oxide.
References Cited (Backward Citations)
US3419573A
Cited
US3564000A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-14 | 1986-08-16 | 1987-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-14 | 1990-08-16 | 1991-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-14 | 1994-08-16 | 1995-02-15 | $7700.00 | Window Closed / Lapsed |