US4374128A
Expired / Lapsed
US
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Substituted deoxyadenosine derivatives
Assignee: Merrell Toraude et Cie
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Filing: 1981-03-13
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Granted: 1983-02-15
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Expires: 2001-03-13
Abstract
Abstract Novel compounds of the following general Formula I are useful pharmacological agents: ##STR1## wherein: Ado represents 5'-deoxyadenosin-5'-yl; R 1 represents methyl, ethyl or, preferably hydrogen; R 2 represents C 1 -C 8 alkylene; R 4 represents C 1 -C 8 alkylene; R 5 represents hydrogen, C 1 -C 6 alkyl or --R 6 NHR 7 ; R 6 represents C 1 -C 4 alkylene; and R 7 represents hydrogen or C 1 -C 6 alkyl; and pharmaceutically acceptable acid addition salts thereof.
Inventors
- 👤 Philippe Bey
- 👤 Michel Jung
- 👤 Michael Kolb
- 👤 Charles Danzin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 00:15
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/16; A; A61; A61P; A61P33/00; A61P33/02; A61P35/00; C07C; C07C255/00
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
75 words
A 5'-N-(aminoalkyl)amino-5'-deoxyadenosine of the formula ##STR23## wherein: Ado represents 5'-deoxyadenosine-5'-yl; R 1 represents hydrogen, methyl or ethyl; R 2 represents C 1 -C 8 alkylene; R 4 represents C 1 -C 8 alkylene; R 5 represents hydrogen, C 1 -C 6 alkyl or --R 6 NHR 7 ; R 6 represents C 1 -C 4 alkylene; and R 7 represents hydrogen or C 1 -C 4 alkyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
75 words
A 5'-N-(aminoalkyl)amino-5'-deoxyadenosine of the formula ##STR23## wherein: Ado represents 5'-deoxyadenosine-5'-yl; R 1 represents hydrogen, methyl or ethyl; R 2 represents C 1 -C 8 alkylene; R 4 represents C 1 -C 8 alkylene; R 5 represents hydrogen, C 1 -C 6 alkyl or --R 6 NHR 7 ; R 6 represents C 1 -C 4 alkylene; and R 7 represents hydrogen or C 1 -C 4 alkyl or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
12 words
A compound as claimed in claim 1 wherein R 1 represents hydrogen.
Claim 4
Dependent Claim
29 words
A compound as claimed in claim 1 wherein R 2 represents ##STR24## each R 8 independently represents hydrogen or methyl and n represents an integer of 1 to 4.
Claim 5
Dependent Claim
25 words
A compound as claimed in claim 1 wherein R 4 represents --(CH 2 ) m -- and m represents an integer of 3 to 7.
Claim 6
Dependent Claim
12 words
A compound as claimed in claim 1 wherein R 5 represents hydrogen.
Claim 7
Dependent Claim
26 words
A compound as claimed in claim 1 wherein R 5 represents --(CH 2 ) p NH 2 and p represents an integer of 2 to 4.
Claim 8
Dependent Claim
68 words
A 5'-N-(aminoalkyl)amino-5'-deoxyadenosine as claimed in claim 1 of the formula ##STR25## wherein: Ado represents 5'-deoxyadenosin-5'-yl; R 1 ' represents hydrogen or methyl; R 5 ' represents hydrogen or --(CH 2 ) p NH 2 ; n represents an integer of 1 to 4; m represents an integer of 3 to 7; and p represents an integer of 2 to 4; or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Dependent Claim
11 words
A compound as claimed in claim 7 wherein n represents 2.
Claim 10
Dependent Claim
11 words
A compound as claimed in claim 7 wherein m represents 5.
Claim 11
Dependent Claim
13 words
A compound as claimed in claim 7 wherein R 5 ' represents hydrogen.
Claim 12
Dependent Claim
19 words
A compound as claimed in claim 7 wherein R 5 ' represents --(CH 2 ) 3 NH 2 .
Claim 13
Dependent Claim
13 words
A compound as claimed in claim 7 wherein R 1 ' represents hydrogen.
Claim 14
Dependent Claim
27 words
A compound as claimed in claim 7 wherein R 1 ' represents hydrogen or methyl, n represents 2, m represents 5 and R 5 ' represents hydrogen.
Claim 15
Dependent Claim
33 words
A compound as claimed in claim 7 wherein R 1 ' represents hydrogen or methyl, n represents 2, m represents 5 and R 5 ' represents --(CH 2 ) 3 NH 2 .
Claim 16
Dependent Claim
39 words
A pharmaceutical composition for controlling undesirable cell proliferation in a warm-blooded animal in need thereof comprising a therapeutically effective amount of a compound as claimed in claim 1 as an active ingredient and a pharmaceutically acceptable diluent or carrier.
Claim 17
Dependent Claim
23 words
A pharmaceutical composition as claimed in claim 15 in unit dosage form containing 1 to 100 mg of said compound per unit dose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-14 | 1986-08-16 | 1987-02-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-14 | 1990-08-16 | 1991-02-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-14 | 1994-08-16 | 1995-02-15 | $7700.00 | Window Closed / Lapsed |