US4373035A
Expired / Lapsed
US
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Isotonic monomer formulations
Assignee: American Dental Association
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Filing: 1981-06-01
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Granted: 1983-02-08
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Expires: 2001-06-01
Abstract
Abstract Application of a composition of matter comprising a solution of water in relatively nontoxic water-stable ethylenically unsaturated monomers, preferably methacrylate and/or acrylate and most preferably methacrylate monomers, which solution is substantially isotonic with normal physiological saline solution. As a further aspect of the invention, the compositions may be prepared by selecting ethylenically unsaturated monomers of varying hydrophilicity or water solubility, equilibrating each such monomer with water to form a two phase system and measuring the concentration of the monomer in the water-rich phase, preparing a mixture of monomers in equilibrium with water such that their cumulative concentration in the water phase is about 0.31 molar, and collecting the monomer-rich phase, which will be saturated with water and will also be isotonic with normal physiological saline.
Inventors
- 👤 Rafael L. Bowen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 00:55
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/06
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
21 words
A composition of matter comprising a solution, substantially isotonic with normal physiological saline solution, of water in water-stable ethylenically unsaturated monomers.
Claim 2
Dependent Claim
21 words
A composition of matter comprising a solution, substantially isotonic with normal physiological saline solution, of water in water-stable ethylenically unsaturated monomers.
Claim 3
Dependent Claim
35 words
A composition of matter comprising a solution of water in water-stable ethylenically unsaturated monomers wherein the osmotic pressure of the solution substantially equals the osmotic pressure of an aqueous 0.31 mole per liter glucose solution.
Claim 4
Dependent Claim
35 words
A composition of matter comprising a solution of water in water-stable ethylenically unsaturated monomers wherein the osmotic pressure of the solution substantially equals the osmotic pressure of an aqueous 0.31 mole per liter glucose solution.
Claim 5
Dependent Claim
25 words
A composition of matter as in claim 1 or 2 wherein the ethylenically unsaturated monomers are selected from the group consisting of methacrylates and acrylates.
Claim 6
Dependent Claim
15 words
A composition of matter as in claim 3 wherein the ethylenically unsaturated monomers are methacrylates.
Claim 7
Dependent Claim
17 words
A composition of matter as in claim 1 or wherein the ethylenically unsaturated monomers are relatively nontoxic.
Claim 8
Dependent Claim
29 words
A composition of matter comprising a solution of water in relatively nontoxic water-stable ethylenically unsaturated monomers which is substantially osmotically equivalent to 0.9 percent by weight aqueous sodium chloride.
Claim 9
Dependent Claim
29 words
A composition of matter comprising a solution of water in relatively nontoxic water-stable ethylenically unsaturated monomers which is substantially osmotically equivalent to 0.9 percent by weight aqueous sodium chloride.
Claim 10
Dependent Claim
29 words
An isotonic monomer formulation, useful as a vehicle for the application of adhesion-promoting surface-active comonomers to the surface of dentin, comprising a composition of matter as in claim 1.
Claim 11
Dependent Claim
29 words
An isotonic monomer formulation, useful as a vehicle for the application of adhesion-promoting surface-active comonomers to the surface of dentin, comprising a composition of matter as in claim 3.
Claim 12
Dependent Claim
29 words
An isotonic monomer formulation, useful as a vehicle for the application of adhesion-promoting surface-active comonomers to the surface of dentin, comprising a composition of matter as in claim 4.
Claim 13
Dependent Claim
32 words
An isotonic monomer formulation as in claim 7 comprising a saturated solution of water in a mixture of about 60 mole percent triethylene glycol dimethacrylate and about 40 mole percent 2-hydroxypropyl methacrylate.
Claim 14
Dependent Claim
31 words
An isotonic monomer formulation as in claim 7 comprising a saturated solution of water in a mixture of about 45 mole percent 2,2-bis[p-(2'-hydroxy-3'-methacryloxypropoxy)phenylene]propane and about 55 mole percent 2-hydroxy propyl methacrylate.
Claim 15
Dependent Claim
24 words
An isotonic monomer formulation as in claim 7 further comprising one or more additives selected from the group consisting of stabilizers, initiators and accelerators.
Claim 16
Dependent Claim
62 words
An isotonic monomer formulation as in claim 12 comprising a saturated solution of water in a mixture of about 40 weight percent 2-hydroxypropyl methacrylate, about 35 weight percent 2,2-bis[p-(2'-hydroxy-3'-methacryloxypropoxy)phenylene]propane, and about 16 weight percent triethylene glycol dimethacrylate, also containing triphenyl antimony as a stabilizer, 2,6-di-t-butyl-4-methylphenol as a stabilizer, hydroquinonemonomethylether as a stabilizer, benzoyl peroxide as an initiator, and DHPT as an accelerator.
Claim 17
Dependent Claim
23 words
A composition of matter comprising a mixture of an isotonic monomer formulation as in claim 7 with at least one adhesion-promoting surface-active comonomer.
Claim 18
Dependent Claim
27 words
A composition of matter as in claim 14 wherein the adhesion-promoting surface active comonomer is selected from the group consisting of N-(2-hydroxy-3-methacryloxypropyl)-N-phenylglycine and polyfunctional surface active comonomers.
Claim 19
Dependent Claim
40 words
A composition of matter as in claim 15 comprising a saturated solution of water in a mixture of about 40 weight percent 2-hydroxypropyl methacrylate, about 35 weight percent 2,2-bis[p-(2'-hydroxy-3'-methacryloxypropoxy)phenylene]propane, about 16 weight percent triethylene glycol dimethacrylate, and about 2% N-(2-hydroxy-3-methacryloxypropyl)-N-phenylglycine.
Claim 20
Dependent Claim
40 words
An isotonic monomer formulation, useful for the protection of body tissues from abstraction or excess application of water, relative to normal homeostatic conditions, during soft tissue replication for scanning electron-micrographic studies, comprising a composition of matter as in claim 1.
Claim 21
Dependent Claim
44 words
An isotonic monomer formulation, useful for the protection of body tissues from abstraction or excess application of water, relative to normal homeostatic conditions, during application of prosthetic applicance formulations for dentistry or orthopedic surgery, comprising a composition of matter as claimed in claim 1.
Claim 22
Dependent Claim
38 words
An isotonic monomer formulation, useful for the protection of body tissues from abstraction or excess application of water, relative to normal homeostatic conditions, during application of bone cement, comprising a composition of matter as claimed in claim 1.
Claim 23
Dependent Claim
40 words
An isotonic monomer formulation, useful for the protection of body tissues from abstraction or excess application of water, relative to normal homeostatic conditions, during application of impression-forming materials to soft tissues, comprising a composition of matter as in claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-07 | 1986-08-09 | 1987-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-07 | 1990-08-09 | 1991-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-07 | 1994-08-09 | 1995-02-08 | $7700.00 | Window Closed / Lapsed |