US4372968A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Granules of sodium ascorbate and the production thereof
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1980-10-29
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Granted: 1983-02-08
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Expires: 2000-10-29
Abstract
Abstract Granules of higher potency of sodium L-ascorbate obtainable by spray-coating sodium L-ascorbate powder in a fluidized-bed granulator with a binder are excellent in terms of color stability and flowability. Tablets obtainable by compressing the granules have a satisfactory mechanical strength.
Inventors
- 👤 Nobuyuki Kitamori
- 👤 Keizi Hemmi
- 👤 Masaya Maeno
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:12
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/365; A61K31/375; A61K9/00; A61K9/14; A61K9/16; A61K9/1682; A61K9/1688; A61K9/20; A61K9/2095
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
146 words
Sodium L-ascorbate granules consisting substantially of sodium L-ascorbate and a binder, wherein the content of sodium L-ascorbate is from about 98.5 to 99.5 weight percent, on dry basis, of the granule and not less than about 80 weight percent of the granule having a particle size of 177 to 840μ which are produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 2
Dependent Claim
146 words
Sodium L-ascorbate granules consisting substantially of sodium L-ascorbate and a binder, wherein the content of sodium L-ascorbate is from about 98.5 to 99.5 weight percent, on dry basis, of the granule and not less than about 80 weight percent of the granule having a particle size of 177 to 840μ which are produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 3
Dependent Claim
21 words
Granules as claimed in claim 1, wherein the binder is a pregelatinized starch, a water-soluble cellulose or a water-soluble high-molecular compound.
Claim 4
Dependent Claim
13 words
Granules as claimed in claim 2, wherein the pregelatinized starch is pregelatinized cornstarch.
Claim 5
Dependent Claim
12 words
Granules as claimed in claim 2, wherein the water-soluble cellulose is hydroxypropylcellulose.
Claim 6
Dependent Claim
14 words
Granules as claimed in claim 2, wherein the water-soluble high-molecular compound is polyvinyl alcohol.
Claim 7
Independent Claim
104 words
A method for producing sodium L-ascorbate granules, which comprises spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and granulating the mixture while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 8
Independent Claim
104 words
A method for producing sodium L-ascorbate granules, which comprises spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and granulating the mixture while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 9
Dependent Claim
21 words
A method according to claim 6, wherein the binder is a pregelatinized starch, a water-soluble cellulose or a water-soluble high-molecular compound.
Claim 10
Dependent Claim
13 words
A method according to claim 7, wherein the pregelatinized starch is pregelatinized cornstarch.
Claim 11
Dependent Claim
12 words
A method according to claim 7, wherein the water-soluble cellulose is hydroxypropylcellulose.
Claim 12
Dependent Claim
14 words
A method according to claim 7, wherein the water-soluble high-molecular compound is polyvinyl alcohol.
Claim 13
Dependent Claim
155 words
Tablets containing sodium L-ascorbate obtained by compressing into tablets granules consisting substantially of sodium L-ascorbate and a binder, the granules comprising sodium L-ascorbate within the range of about 98.5 to 99.5 weight percent on a dry basis of the granule and not less than about 80 weight percent of the granule having a particle size of 177 to 840μ and being produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 14
Dependent Claim
155 words
Tablets containing sodium L-ascorbate obtained by compressing into tablets granules consisting substantially of sodium L-ascorbate and a binder, the granules comprising sodium L-ascorbate within the range of about 98.5 to 99.5 weight percent on a dry basis of the granule and not less than about 80 weight percent of the granule having a particle size of 177 to 840μ and being produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponding to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 15
Dependent Claim
23 words
Tablets containing sodium L-ascorbate as claimed in claim 11, wherein said tablets are obtained by compression in the presence of L-ascorbic acid granules.
Claim 16
Dependent Claim
21 words
A tablet according to claim 11, wherein the binder is a pregelatinized starch, a water-soluble cellulose, or a water-soluble high-molecular compound.
Claim 17
Dependent Claim
13 words
A tablet according to claim 13, wherein the pregelatinized starch is pregelatinized cornstarch.
Claim 18
Dependent Claim
12 words
A tablet according to claim 13, wherein the water-soluble cellulose is hydroxypropylcellulose.
Claim 19
Dependent Claim
14 words
A tablet according to claim 13, wherein the water-soluble high-molecular compound is polyvinyl alcohol.
Claim 20
Independent Claim
153 words
A method for producing tablets containing sodium L-ascorbate by compressing granules consisting substantially of sodium L-ascorbate and a binder, the granules comprising sodium L-ascorbate within the range of about 98.5 to 99.5 weight percent on a dry basis and not less than about 80 weight percent of the granule having a particle size of 177 to 840∞ and being produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponds to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 21
Independent Claim
153 words
A method for producing tablets containing sodium L-ascorbate by compressing granules consisting substantially of sodium L-ascorbate and a binder, the granules comprising sodium L-ascorbate within the range of about 98.5 to 99.5 weight percent on a dry basis and not less than about 80 weight percent of the granule having a particle size of 177 to 840∞ and being produced by spraying sodium L-ascorbate powder having a particle size of not more than 250μ and not less than about 80 weight percent of said powder having a particle size of not more than 149μ, while allowing it to fluidize in a fluidized-bed granulator, with a solution containing a binder in an amount corresponds to about 0.5 to 1.5 weight percent of the total weight of finished product on a dry basis, and while maintaining the water content of the composition during the granulating process below about 7 weight percent throughout the entire process.
Claim 22
Dependent Claim
19 words
A method as claimed in claim 17, wherein the compression is conducted in the presence of L-ascorbic acid granules.
Claim 23
Dependent Claim
21 words
A method according to claim 17, wherein the binder is a pregelatinized starch, a water-soluble cellulose or a water-soluble high-molecular compound.
Claim 24
Dependent Claim
13 words
A method according to claim 19, wherein the pregelatinized starch is pregelatinized cornstarch.
Claim 25
Dependent Claim
12 words
A method according to claim 19, wherein the water-soluble cellulose is hydroxypropylcellulose.
Claim 26
Dependent Claim
14 words
A method according to claim 19, wherein the water-soluble high-molecular compound is polyvinyl alcohol.
References Cited (Backward Citations)
US3493659A
Cited
US4036948A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-02-07 | 1986-08-09 | 1987-02-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-02-07 | 1990-08-09 | 1991-02-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-02-07 | 1994-08-09 | 1995-02-08 | $7700.00 | Window Closed / Lapsed |