US4371527A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic process with diphosphonate compounds
Assignee: Symphar SA
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Filing: 1980-11-18
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Granted: 1983-02-01
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Expires: 2000-11-18
Abstract
Abstract A method of increasing the quantity of circulating high density lipoproteins and clearing cholesterol from certain tissues, comprising administering to a human an effective amount of a compound of the formula ##STR1## where X is H, OH, ##STR2## or NH 2 ; R and R' identical or different are H, CH 3 or C 2 H 5 ; m is zero or 1; and A is selected from the group comprising (CH 3 ) 3 C--, Y--C 6 H 4 --, Y--C 6 H 4 --O--C(CH 3 ) 2 --, Y--C 6 H 4 --C(CH 3 ) 2 --, Y--C 6 H 4 --C(O)--C 6 H 4 --, Y--C 6 H 4 --(CH 2 ) n -- and Y--C 6 H 4 --O--(CH 2 ) n --, where n is an integer from 1 to 6 and Y is H, CH 3 , OCH 3 or Cl. The present invention is a division of our copending application Ser. No. 114,423, filed Jan. 22, 1980, now U.S. Pat. No. 4,309,364.
Inventors
- 👤 Craig L. Bentzen
- 👤 Lan Nguyen Mong
- 👤 Eric Niesor
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 11:31
CPC Classifications
C; C07; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/38; C07F9/40; C07F9/4003; C07F9/4056; A; A61; A61K; A61K31/00; A61K31/66; C07F9/3804; C07F9/3808; C07F9/3839; C07F9/3882; C07F9/4006; C07F9/4025
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
110 words
A method of increasing the quantity of circulating high density lipoproteins and clearing cholesterol from various tissues, in humans, comprising administering to a human an amount effective to increase the quantity of circulating high density lipoproteins and to clear cholesterol from various tissues, of a diphosphonate compound of ##STR32## where X is H, OH, ##STR33## or NH 2 ; R and R' identical or different are H, CH 3 or C 2 H 5 ; m is zero or 1; and A is selected from the group consisting of ##STR34## where n is an integer from 1 to 6 and Y is H, CH 3 , OCH 3 or Cl.
Claim 2
Independent Claim
110 words
A method of increasing the quantity of circulating high density lipoproteins and clearing cholesterol from various tissues, in humans, comprising administering to a human an amount effective to increase the quantity of circulating high density lipoproteins and to clear cholesterol from various tissues, of a diphosphonate compound of ##STR32## where X is H, OH, ##STR33## or NH 2 ; R and R' identical or different are H, CH 3 or C 2 H 5 ; m is zero or 1; and A is selected from the group consisting of ##STR34## where n is an integer from 1 to 6 and Y is H, CH 3 , OCH 3 or Cl.
Claim 3
Dependent Claim
26 words
A method according to claim 1, in which said compound is of formula (Ia) ##STR35## where R, R' and A are as defined in claim 1.
Claim 4
Dependent Claim
26 words
A method according to claim 1, in which said compound is of formula (Ib) ##STR36## where R, R' and A are as defined in claim 1.
Claim 5
Dependent Claim
26 words
A method according to claim 1, in which said compound is of formula (Ic) ##STR37## where R, R' and A are as defined in claim 1.
Claim 6
Dependent Claim
18 words
A method according to claim 1 in which Y is H or a chlorine atom in para position.
Claim 7
Dependent Claim
15 words
A method according to claim 1, in which said compound is tetramethyl 1(p-chlorophenyl)methane 1-hydroxy 1-1-diphosphonate.
Claim 8
Dependent Claim
15 words
A method according to claim 1, in which said compound is tetramethyl 2-2-dimethyl 2-(p-chlorophenoxy)ethane 1-hydroxy-1,1-diphosphonate.
Claim 9
Dependent Claim
15 words
A method according to claim 1, in which said compound is tetramethyl 1-[4(4'-chlorobenzoyl)phenyl]-methane 1-hydroxy 1,1-diphosphonate.
Claim 10
Dependent Claim
13 words
A method according to claim 1, in which said compound is dimethyl 1[(dimethoxyphosphinyl)p-chlorobenzyl]-phosphate.
Claim 11
Dependent Claim
16 words
A method according to claim 1, in which said compound is dimethyl [1(dimethoxyphosphinyl) 2,2-dimethyl 2-phenyl]-ethyl phosphate.
Claim 12
Dependent Claim
15 words
A method according to claim 1, in which said compound is dimethyl [1(dimethoxyphosphinyl)2,2-dimethyl 2(p-chlorophenyl]ethyl phosphate.
Claim 13
Dependent Claim
14 words
A method according to claim 1, in which said compound is tetraethyl 4-phenylbutylidene 1,1-diphosphonate.
Claim 14
Dependent Claim
14 words
A method according to claim 1, in which said compound is 4-phenylbutylidene 1,1-diphosphonic acid.
Claim 15
Dependent Claim
14 words
A method according to claim 1, in which said compound is tetramethyl 4-phenylbutylidene 1,1-diphosphonate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-31 | 1986-08-02 | 1987-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-31 | 1990-08-02 | 1991-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-31 | 1994-08-02 | 1995-02-01 | $7700.00 | Window Closed / Lapsed |