US4371522A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Keratoconjunctivitis sicca therapy
Assignee: Individual
•
Filing: 1980-11-24
•
Granted: 1983-02-01
•
Expires: 2000-11-24
Abstract
Abstract Discomfort in patients suffering from keratoconjunctivitis sicca is considerably relieved by instilling into the eyes of the afflicted patient a small amount of hypotonic solution suitably of a strength of between 25 and 75 percent isotonicity.
Inventors
- 👤 Jeffrey P. Gilbard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 07:14
CPC Classifications
A; A61; A61K; A61K33/00; A61K33/14
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
43 words
A method of relieving discomfort in eyes of patients afflicted with keratoconjunctivitis sicca which comprises adjusting the tonicity of the eyes by contacting the eyes of said patients with an ophthalmically acceptable hypotonic solution of a concentration of between 75 to 225 mOsm/l.
Claim 2
Independent Claim
43 words
A method of relieving discomfort in eyes of patients afflicted with keratoconjunctivitis sicca which comprises adjusting the tonicity of the eyes by contacting the eyes of said patients with an ophthalmically acceptable hypotonic solution of a concentration of between 75 to 225 mOsm/l.
Claim 3
Dependent Claim
15 words
A method of claim 1 wherein the concentration is between about 110 and 225 mOsm/l.
Claim 4
Dependent Claim
17 words
A method of claim 1 wherein the hypotonic solution comprises substantially an aqueous solution of sodium chloride.
Claim 5
Dependent Claim
18 words
A method of claim 1 wherein the solution is buffered to a pH of between 4.5 and 7.8.
Claim 6
Dependent Claim
19 words
A method of claim 1 wherein the mode of contacting is bathing the afflicted eye with said hypotonic solution.
Claim 7
Dependent Claim
19 words
A method of claim 1 wherein the mode of contacting is instilling said hypotonic solution into the afflicted eye.
Claim 8
Dependent Claim
37 words
A method of claim 6 which comprises instilling between 1 and 5 drops (0.015 to 0.2 ml) into each affected eye at intervals of between 0.5 and 5 hours, or as needed, while the patient is awake.
References Cited (Backward Citations)
US2547653A
Cited
US4039662A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-31 | 1986-08-02 | 1987-02-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-31 | 1990-08-02 | 1991-02-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-31 | 1994-08-02 | 1995-02-01 | $7700.00 | Window Closed / Lapsed |