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US4369138A Expired / Lapsed US ⏱️ 0.0 years remaining

Parathyroid radioimmunoassay

Assignee: Diasorin SpA
•
Filing: 1981-09-16
•
Granted: 1983-01-18
•
Expires: 2001-09-16
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Abstract

Abstract A method for the radioimmunoassay of parathyroid hormone in mammalian serum. The method is an improvement on previous double antibody radioimmunoassays in that spurious assay results caused by the nonspecific interaction of serum proteins with the labeled peptide is eliminated by the labeling of a specific portion of either human or bovine parathyroid molecule. The 65-84 portion of human or bovine parathyroid hormone, as radioactively labeled, is incorporated in the assay as the labeled peptide. A chicken antibody with a high affinity for the 65-84 portion of human parathyroid hormone is incorporated in the assay as the first antibody. The invention further pertains to compounds useful in practicing the method, namely X 64 -hPTH 65-84 and Y-X 64 -hPTH 65-84 wherein X is either histidyl, tyramyl, histamyl, or tyrosyl, and wherein Y is either 125 I or 131 I.

Inventors

  • 👤 Arnold W. Lindall

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-05 07:31
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/74; G01N33/78; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/854

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 24 words
A compound having the formula X 64 -hPTH 65-84 wherein X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 2
Dependent Claim 24 words
A compound having the formula X 64 -hPTH 65-84 wherein X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 3
Dependent Claim 10 words
The compound of claim 1 wherein said member is tyrosyl.
Claim 4
Dependent Claim 39 words
A compound having the formula Y-X 64 -hPTH 65-84 wherein Y is a member of the group consisting of 131 I and 125 I and X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 5
Dependent Claim 39 words
A compound having the formula Y-X 64 -hPTH 65-84 wherein Y is a member of the group consisting of 131 I and 125 I and X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 6
Dependent Claim 15 words
The compound of claim 3 wherein said compound is 125 I-Tyr 64 -hPTH 65-84 .
Claim 7
Dependent Claim 25 words
A compound having the formula X 64 -bovine PTH 65-84 wherein X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 8
Dependent Claim 25 words
A compound having the formula X 64 -bovine PTH 65-84 wherein X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 9
Dependent Claim 10 words
The compound of claim 5 wherein said member is tyrosyl.
Claim 10
Dependent Claim 40 words
A compound having the formula Y-X 64 -bovine PTH 65-84 wherein Y is a member of the group consisting of 131 I and 125 I and X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 11
Dependent Claim 40 words
A compound having the formula Y-X 64 -bovine PTH 65-84 wherein Y is a member of the group consisting of 131 I and 125 I and X is a member of the group consisting of histidyl, tyramyl, histamyl, and tyrosyl.
Claim 12
Dependent Claim 16 words
The compound of claim 7 wherein said compound is 125 I-Tyr 64 -bovine PTH 65-84 .

References Cited (Backward Citations)

US4146602A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-01-17 1986-07-19 1987-01-18 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-01-17 1990-07-19 1991-01-18 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-01-17 1994-07-19 1995-01-18 $7700.00 Window Closed / Lapsed

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