US4368138A
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Water soluble thymidine derivative
Assignee: Individual
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Filing: 1980-01-08
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Granted: 1983-01-11
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Expires: 2000-01-08
Abstract
Abstract Thymidine may have its solubility in water increased by as much as 10 times or even more by combining the thymidine with a solubilizing agent, such as a salicylate derivative selected from salicylic acid, amino and methyleneamino substituted salicylic acids and salts and esters thereof. The thymidine and solubilizing agent may be combined by grinding in the dry state. The compounds are most conveniently used in approximately equimolar quantities.
Inventors
- 👤 Israel Marcus
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:02
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; A; A61; A61K; A61K31/00; A61K31/60; A61K47/00; A61K47/06; A61K47/08; A61K47/12; A61K47/16; A61K47/18; A61K47/183
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
48 words
A solubilized thymidine product having increased solubility in aqueous media comprising thymidine and an amount of a solubilizing agent effective to increase the thymidine solubility in aqueous media, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 2
Dependent Claim
48 words
A solubilized thymidine product having increased solubility in aqueous media comprising thymidine and an amount of a solubilizing agent effective to increase the thymidine solubility in aqueous media, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 3
Dependent Claim
32 words
A solubilized thymidine product having increased solubility in aqueous media comprising thymidine and an amount of a solubilizing agent selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 4
Dependent Claim
32 words
A solubilized thymidine product having increased solubility in aqueous media comprising thymidine and an amount of a solubilizing agent selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 5
Dependent Claim
12 words
The product of claim 2 wherein the methyleneaminosalicylic acid is p-methyleneaminosalicylic acid.
Claim 6
Dependent Claim
12 words
The product of claim 2 wherein the salts are alkali metal salts.
Claim 7
Dependent Claim
12 words
The product of claim 2 wherein the salt is the sodium salt.
Claim 8
Dependent Claim
18 words
The product of claim 2 wherein the solubilizing agent is present in about equimolar proportions with the thymidine.
Claim 9
Dependent Claim
70 words
An aqueous solution of thymidine containing up to at least about 0.1 gram thymidine per mililiter, the thymidine being present in an amount greater than the normal solubility of thymidine in water and the solution containing a thymidine solubilizing agent effective to increase the thymidine solubility in the aqueous media, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 10
Dependent Claim
70 words
An aqueous solution of thymidine containing up to at least about 0.1 gram thymidine per mililiter, the thymidine being present in an amount greater than the normal solubility of thymidine in water and the solution containing a thymidine solubilizing agent effective to increase the thymidine solubility in the aqueous media, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 11
Dependent Claim
51 words
An aqueous solution of thymidine containing up to at least about 0.1 g thymidine per ml, the thymidine being present in an amount greater than the normal solubility of thymidine in water, the solution containing a solubilizing agent selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 12
Dependent Claim
51 words
An aqueous solution of thymidine containing up to at least about 0.1 g thymidine per ml, the thymidine being present in an amount greater than the normal solubility of thymidine in water, the solution containing a solubilizing agent selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 13
Dependent Claim
12 words
The solution of claim 8 wherein the methyleneaminosalicylic acid is p-methyleneaminosalicylic acid.
Claim 14
Dependent Claim
12 words
The solution of claim 8 wherein the salts are alkali metal salts.
Claim 15
Dependent Claim
12 words
The solution of claim 8 wherein the salt is the sodium salt.
Claim 16
Dependent Claim
18 words
The solution of claim 8 wherein the solubilizing agent is present in about equimolar proportions with the thymidine.
Claim 17
Independent Claim
68 words
A method of increasing the solubility of thymidine in aqueous solutions comprising treating thymidine with a thymidine solubilizing agent in an amount effective to increase the aqueous solubility of the thymidine above its normal aqueous solubility and up to at least 0.1 grams thymidine per ml. of water, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 18
Independent Claim
68 words
A method of increasing the solubility of thymidine in aqueous solutions comprising treating thymidine with a thymidine solubilizing agent in an amount effective to increase the aqueous solubility of the thymidine above its normal aqueous solubility and up to at least 0.1 grams thymidine per ml. of water, the thymidine solubilizing agent being selected from the group consisting of salicylic acid, its derivatives and salts and esters thereof.
Claim 19
Independent Claim
64 words
A method of increasing the solubility of thymidine in aqueous solutions comprising treating thymidine with a solubilizing compound in an amount effective to increase the aqueous solubility of the thymidine above its normal aqueous solubility and up to at least 0.1 g thymidine per ml of water, the solubilizing agent being selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 20
Independent Claim
64 words
A method of increasing the solubility of thymidine in aqueous solutions comprising treating thymidine with a solubilizing compound in an amount effective to increase the aqueous solubility of the thymidine above its normal aqueous solubility and up to at least 0.1 g thymidine per ml of water, the solubilizing agent being selected from the group consisting of methyleneaminosalicylic acid and esters and salts thereof.
Claim 21
Dependent Claim
12 words
The method of claim 14 wherein the methyleneaminosalicylic acid is p-methyleneaminosalicylic acid.
Claim 22
Dependent Claim
12 words
The method of claim 14 wherein the salts are alkali metal salts.
Claim 23
Dependent Claim
12 words
The method of claim 14 wherein the salt is the sodium salt.
Claim 24
Dependent Claim
25 words
The method of claim 14 wherein the solubilizing agent is added to the thymidine in proportions of up to about equimolar proportions with the thymidine.
Claim 25
Dependent Claim
33 words
The method of claim 14 wherein the solubilizing compound and thymidine are mixed in the dry state and the treating is conducted by grinding the two products together to form a solubilized thymidine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-10 | 1986-07-12 | 1987-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-10 | 1990-07-12 | 1991-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-10 | 1994-07-12 | 1995-01-11 | $7700.00 | Window Closed / Lapsed |