US4367216A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Triiodinated 5-aminoisophthalic acid derivatives
Assignee: Bayer Pharma AG
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Filing: 1980-06-27
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Granted: 1983-01-04
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Expires: 2000-06-27
Abstract
Abstract Compounds of the formula <IMAGE> wherein R1 is hydroxy-C2-8-alkyl containing 1-5 OH-groups; R2 is hydrogen, C1-4-alkyl or R1; R3 and R4 can be identical or different, and each independently is hydrogen or C1-4-alkyl; and X is straight chain or branched C2-12 alkylene interrupted by sulfur or selenium atoms, and, optionally, additionally interrupted by oxygen atoms, by a di(C1-4-alkyl)silyl group or a tetra(C1-4-alkyl)disiloxane group; are very useful as X-ray contrast media opaque agents, which can be employed even in lymphography.
Inventors
- 👤 Wolfgang Mutzel
- 👤 Hans-Martin Siefert
- 👤 Ulrich Speck
- 👤 Heinrich Pfeiffer
- 👤 Paul-Eberhard Schulze
- 👤 Bernhard Acksteiner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 20:15
CPC Classifications
C; C07; C07C; C07C391/00; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/0803; C07F7/081; C07F7/0834; C07F7/0838
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
85 words
A compound of the formula ##STR8## wherein R 1 is hydroxy-C 2-8 -alkyl containing 1-5 OH groups; R 2 is hydrogen, C 1-4 -alkyl, or R 1 ; R 3 and R 4 can be identical or different, and each independently is hydrogen or C 1-4 -alkyl; and X is straight chain or branched C 2-12 alkylene interrupted by 1-4 sulfur or selenium atoms, and, optionally, additionally interrupted by 1-3 oxygen atoms, by a di(C 1-4 -alkyl)silyl group or a tetra (C 1-4 -alkyl)disiloxane group.
Claim 2
Dependent Claim
85 words
A compound of the formula ##STR8## wherein R 1 is hydroxy-C 2-8 -alkyl containing 1-5 OH groups; R 2 is hydrogen, C 1-4 -alkyl, or R 1 ; R 3 and R 4 can be identical or different, and each independently is hydrogen or C 1-4 -alkyl; and X is straight chain or branched C 2-12 alkylene interrupted by 1-4 sulfur or selenium atoms, and, optionally, additionally interrupted by 1-3 oxygen atoms, by a di(C 1-4 -alkyl)silyl group or a tetra (C 1-4 -alkyl)disiloxane group.
Claim 3
Dependent Claim
20 words
A compound of claim 1, wherein R 1 is a C 2-4 -straight chain alkyl substituted by 1-3 OH groups.
Claim 4
Dependent Claim
19 words
A compound of claim 1, wherein R 1 is a branched C 3-5 -alkyl substituted by 1-3 OH groups.
Claim 5
Dependent Claim
14 words
A compound of claim 2 or 3 wherein R 1 contains two OH groups.
Claim 6
Dependent Claim
20 words
A compound of claim 1, wherein R 2 , R 3 and R 4 are straight chain C 1-2 -alkyl.
Claim 7
Dependent Claim
22 words
A compound of claim 1, wherein X is straight chain C 2-4 -alkylene interrupted by 1-3 S atoms or 1-2 Se atoms.
Claim 8
Dependent Claim
24 words
A compound of claim 1, wherein X is C 2-8 -alkylene interrupted by a di(C 1-4 alkyl)silyl group or a tetra(C 2-8 alkyl)disiloxane group.
Claim 9
Dependent Claim
8 words
3,3'-Thiodipropionic acid bis[3,5-bis(2,3-dihydroxypropyl-N-methylcarbamoyl)-2,4,6-triiodoanilide], a compound of claim 1.
Claim 10
Dependent Claim
8 words
3,6-Dithiaoctanedioic acid bis(3,5-bis(2,3-dihydroxypropyl-N-methylcarbamoyl)-2,4,6-triiodoanilide], a compound of claim 1.
Claim 11
Dependent Claim
8 words
4,4,6,6-Tetramethyl-4,6-disila-5-oxanonanedioic acid bis[3,5-bis(2,3-dihydroxypropyl-N-methylcarbamoyl)-2,4,6-triiodoanilide], a compound of claim 1.
Claim 12
Dependent Claim
27 words
A pharmaceutical X-ray contrast medium comprising an amount of a compound of claim 1 or 8 effective as an X-ray opaque agent, and a pharmaceutically acceptable carrier.
Claim 13
Dependent Claim
19 words
The pharmaceutical X-ray contrast medium of claim 11 comprising 20-400 mg I/ml of total composition of the opaque agent.
Claim 14
Dependent Claim
58 words
A method of X-ray visualization of a body part of a host which comprises prior to the taking of X-rays, administering to the host an amount of a compound of claim 1 or 8 effective as an X-ray opaque agent for the body part to be visualized and, subsequently, taking X-rays of the body part to be visualized.
Claim 15
Dependent Claim
11 words
The method of claim 13, wherein the visualization is by lymphography.
Claim 16
Dependent Claim
42 words
A method of rendering a body part of a host visualizable by X-rays, which comprises administering to the host an amount of a compound of claim 1 or 8 effective as an X-ray opaque agent for the body part to be visualized.
References Cited (Backward Citations)
US4239747A
Cited
US4139605A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-03 | 1986-07-05 | 1987-01-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-03 | 1990-07-05 | 1991-01-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-03 | 1994-07-05 | 1995-01-04 | $7700.00 | Window Closed / Lapsed |