US4364941A
Expired / Lapsed
US
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Method for regulating bone metabolism of warm-blooded animals, and pharmaceutical compositions thereof
Assignee: Teijin Ltd
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Filing: 1981-08-31
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Granted: 1982-12-21
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Expires: 2001-08-31
Abstract
Abstract A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α, 24-dihydroxycholecalciferol (1α, 24-DHCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) to said warm-blooded animal, and a pharmaceutical composition comprising 1α,24-DHCC, 24,25-DHCC and a pharmaceutically acceptable carrier. According to the invention, a condition of abnormal bone metabolism requiring long-term therapy, such as osteoporosis, can be safely treated by administering 1α, 24-DHCC and 24,25-DHCC over a long period of time because no substantial adverse effect of 1α, 24-DHCC on the metabolis of 24,25-DHCC is observed.
Inventors
- 👤 Mamoru Kiyoki
- 👤 Hiroyoshi Endo
- 👤 Tatsuyuki Naruchi
- 👤 Yoshinobu Hashimoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:28
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/59; A61P; A61P3/00; A61P3/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
45 words
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal, said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism.
Claim 2
Independent Claim
45 words
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal, said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism.
Claim 3
Dependent Claim
11 words
The method of claim 1 wherein said warm-blooded animal is man.
Claim 4
Dependent Claim
13 words
The method of claim 1 wherein said warm-blooded animal is other than man.
Claim 5
Independent Claim
39 words
A method for remedying abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism.
Claim 6
Independent Claim
39 words
A method for remedying abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism.
Claim 7
Dependent Claim
18 words
The method of claim 4 wherein the abnormal bone metabolism involves a decrease in the amount of bonemass.
Claim 8
Dependent Claim
22 words
The method of claim 4 wherein the abnormal bone metabolism is the derangement of normal reactivity of bones with calcium homeostatic hormone.
Claim 9
Independent Claim
36 words
A method for preventing the abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of a 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to maintain normal bone metabolism.
Claim 10
Independent Claim
36 words
A method for preventing the abnormal bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of a 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to the warm-blooded animal said amount being sufficient to maintain normal bone metabolism.
Claim 11
Independent Claim
66 words
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to said warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism so that the calcium level in the serum of said warm-blooded animal is maintained at 8 to 12 mg/dl of serum.
Claim 12
Independent Claim
66 words
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol to said warm-blooded animal said amount being sufficient to bring abnormal bone metabolism to a normal bone metabolism or to maintain normal bone metabolism so that the calcium level in the serum of said warm-blooded animal is maintained at 8 to 12 mg/dl of serum.
Claim 13
Dependent Claim
30 words
A pharmaceutical composition for regulating the bone metabolism of a warm-blooded animal which comprises a pharmaceutically effective amount of a mixture of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
30 words
A pharmaceutical composition for regulating the bone metabolism of a warm-blooded animal which comprises a pharmaceutically effective amount of a mixture of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 15
Dependent Claim
28 words
A medicament for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising a unit dosage of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 16
Dependent Claim
28 words
A medicament for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising a unit dosage of 1α,24-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 17
Dependent Claim
37 words
A medicament for oral administration for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising 0.05 to 10 μg of 1α,24-dihydroxycholecalciferol and 0.5 to 25 μg of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 18
Dependent Claim
37 words
A medicament for oral administration for regulating the bone metabolism of a warm-blooded animal in unit dosage form comprising 0.05 to 10 μg of 1α,24-dihydroxycholecalciferol and 0.5 to 25 μg of 24,25-dihydroxycholecalciferol and a pharmaceutically acceptable carrier.
Claim 19
Dependent Claim
15 words
The medicament of claim 10 or 11 wherein the 1α,24-dihydroxycholecalciferol is 1α,24(R)-dihydroxycholecalciferol, 1α,24(S)-dihydroxycholecalciferol, or 1α,24(R,S)-dihydroxycholecalciferol.
Claim 20
Dependent Claim
15 words
The medicament of claim 10 or 11 wherein said 24,25-dihydroxycholecalciferol is 24(R),25-dihydroxycholecalciferol, 24(S),25-dihydroxycholecalciferol, or 24(R,S),25-dihydroxycholecalciferol.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-20 | 1986-06-21 | 1986-12-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-20 | 1990-06-21 | 1990-12-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-20 | 1994-06-21 | 1994-12-21 | $7700.00 | Window Closed / Lapsed |