US4363813A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-(3,4,5-Trimethoxyphenyl)-4,5-disubstituted thiazoles
Assignee: Kureha Corp
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Filing: 1980-06-27
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Granted: 1982-12-14
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Expires: 2000-06-27
Abstract
Abstract 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazoles, each of which has an anti-peptic ulcer activity, and methods for producing the same are disclosed herein.
Inventors
- 👤 Takao Kawasaki
- 👤 Yoshiaki Osaka
- 👤 Tadashi Tsuchiya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 04:02
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/24; C07D277/28; C07D277/32; C07D277/56
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
83 words
2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole represented by the formula: ##STR20## wherein R 1 represents an alkyl group of C 1 to C 3 and R 2 represents a hydrogen atom, an alkyl group of C 1 to C 3 , an acetyl group, a carboxyl group of ester group thereof with an alcohol of C 1 to C 3 , a carbamoyl group or a hydrazinocarbonyl group, and wherein the carbonyl group of said acetyl group may also be converted to oxime, oxime-acetate, semicarbazide or guanylhydrazone.
Claim 2
Dependent Claim
83 words
2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole represented by the formula: ##STR20## wherein R 1 represents an alkyl group of C 1 to C 3 and R 2 represents a hydrogen atom, an alkyl group of C 1 to C 3 , an acetyl group, a carboxyl group of ester group thereof with an alcohol of C 1 to C 3 , a carbamoyl group or a hydrazinocarbonyl group, and wherein the carbonyl group of said acetyl group may also be converted to oxime, oxime-acetate, semicarbazide or guanylhydrazone.
Claim 3
Dependent Claim
50 words
2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole according to claim 1 wherein said thiazole is represented by the formula: ##STR21## wherein R represents a methyl group, a carboxyl group, an ethoxycarbonyl group, an acetyl group, a carbamoyl group, a hydrazinocarbonyl group or an acetyl group of which the carbonyl group is converted to a thiosemicarbazone.
Claim 4
Dependent Claim
127 words
A pharmaceutical composition for treating peptic ulcer in dosage unit form, which comprises an effective amount of a compound of 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole represented by the formula: ##STR22## wherein R 1 represents an alkyl group of C 1 to C 3 and R 2 represents a hydrogen atom, an alkyl group of C 1 to C 3 , an acetyl group, a carboxyl group or an ester group thereof with an alcohol of C 1 to C 3 , a carbamoyl group or a hydrazinocarbonyl group, with the proviso that both R 1 and R 2 do not represent simultaneously hydrogen atoms, and wherein the carbonyl group of said acetyl group may also be converted to oxime, oxime-acetate, semicarbazide or guanylhydrazone; and a pharmaceutically acceptable carrier or excipient.
Claim 5
Dependent Claim
127 words
A pharmaceutical composition for treating peptic ulcer in dosage unit form, which comprises an effective amount of a compound of 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole represented by the formula: ##STR22## wherein R 1 represents an alkyl group of C 1 to C 3 and R 2 represents a hydrogen atom, an alkyl group of C 1 to C 3 , an acetyl group, a carboxyl group or an ester group thereof with an alcohol of C 1 to C 3 , a carbamoyl group or a hydrazinocarbonyl group, with the proviso that both R 1 and R 2 do not represent simultaneously hydrogen atoms, and wherein the carbonyl group of said acetyl group may also be converted to oxime, oxime-acetate, semicarbazide or guanylhydrazone; and a pharmaceutically acceptable carrier or excipient.
Claim 6
Dependent Claim
53 words
A pharmaceutical composition of claim 3, wherein the compound of 2-(3,4,5-trimethoxyphenyl)-4,5-disubstituted thiazole is represented by the formula: ##STR23## wherein R represents a methyl group, a carboxyl group, an ethoxycarbonyl group, an acetyl group, a carbamoyl group, a hydrazinocarbonyl group or an acetyl group of which the carbonyl group is converted to a thiosemicarbazone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-13 | 1986-06-14 | 1986-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-13 | 1990-06-14 | 1990-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-13 | 1994-06-14 | 1994-12-14 | $7700.00 | Window Closed / Lapsed |