US4363794A
Expired / Lapsed
US
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Oral composition for caries prophylaxis
Assignee: Lion Corp
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Filing: 1978-10-06
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Granted: 1982-12-14
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Expires: 1998-10-06
Abstract
Abstract An oral composition is disclosed which comprises a stannous salt such as stannous fluoride, a water-soluble fluoride salt such as sodium fluoride and an orally acceptable acid such as L-ascorbic acid, lactic acid, malonic acid, tartaric acid, citric acid, hydrochloric acid and pyrophosphoric acid, the molar ratio of fluoride ion to stannous ion being in the range of 3.2 to 7:1, preferably 3.5-6:1, in an aqueous condition and the pH of the composition being in the range of from 2 to 4. The composition exhibits excellent effects on the inhibition of dental caries.
Inventors
- 👤 Yoshihito Ochiai
- 👤 Syozi Nakashima
- 👤 Midori Hayashi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:44
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K6/00; A61K6/60; A61K6/69; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/30; A61K8/33; A61K8/36; A61K8/362; A61K8/365; A61K8/67; A61K8/676
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
171 words
An oral composition for caries prophylaxis comprising a stannous salt, a water-soluble fluoride salt selected from the group consisting of sodium fluoride, potassium fluoride and mixtures thereof, and an orally acceptable acid selected from the group consisting of a monocarboxylic acid, a dicarboxylic acid, a tricarboxylic acid, a mineral acid and mixtures thereof, said stannous salt being present in the range of from 0.07% by weight of the total amount of the composition as stannous ion to the saturated state in water, the molar ratio of fluoride ion to stannous ion being in the range of from 3.5:1 to 5.7:1 in the aqueous condition, the molar ratio of said monocarboxylic acid to stannous ion being in the range of from 0.8×0.5 n :1 to 30×0.6 n :1, the exponent "n" being the weight percent content of the stannous ion in the composition, and said orally acceptable acid being present in the composition in such an amount that the pH of the composition is in the range of from 2 to 4.
Claim 2
Dependent Claim
171 words
An oral composition for caries prophylaxis comprising a stannous salt, a water-soluble fluoride salt selected from the group consisting of sodium fluoride, potassium fluoride and mixtures thereof, and an orally acceptable acid selected from the group consisting of a monocarboxylic acid, a dicarboxylic acid, a tricarboxylic acid, a mineral acid and mixtures thereof, said stannous salt being present in the range of from 0.07% by weight of the total amount of the composition as stannous ion to the saturated state in water, the molar ratio of fluoride ion to stannous ion being in the range of from 3.5:1 to 5.7:1 in the aqueous condition, the molar ratio of said monocarboxylic acid to stannous ion being in the range of from 0.8×0.5 n :1 to 30×0.6 n :1, the exponent "n" being the weight percent content of the stannous ion in the composition, and said orally acceptable acid being present in the composition in such an amount that the pH of the composition is in the range of from 2 to 4.
Claim 3
Dependent Claim
186 words
An oral composition for caries prophylaxis comprising a stannous salt, a water-soluble fluoride salt selected from the group consisting of sodium fluoride, potassium fluoride and mixtures thereof, and an orally acceptable acid selected from the group consisting of a monocarboxylic acid, a dicarboxylic acid, a tricarboxylic acid, a mineral acid and mixtures thereof, said stannous salt being present in the range of from 0.07% by weight of the total amount of the composition as stannous ion to the saturated state in water, the molar ratio of fluoride ion to stannous ion being in the range of from 3.5:1 to 5.7:1 in the aqueous condition, the molar ratio of the acid selected from the group consisting of a dicarboxylic acid, a tricarboxylic acid and a mineral acid to stannous ion being in the range of from 0.2×0.6 n :1 to 5×0.6 n :1, the exponent "n" being the weight percent content of the stannous ion in the composition, and said orally acceptable acid being present in the composition in such an amount that the pH of the composition is in the range of from 2 to 4.
Claim 4
Dependent Claim
186 words
An oral composition for caries prophylaxis comprising a stannous salt, a water-soluble fluoride salt selected from the group consisting of sodium fluoride, potassium fluoride and mixtures thereof, and an orally acceptable acid selected from the group consisting of a monocarboxylic acid, a dicarboxylic acid, a tricarboxylic acid, a mineral acid and mixtures thereof, said stannous salt being present in the range of from 0.07% by weight of the total amount of the composition as stannous ion to the saturated state in water, the molar ratio of fluoride ion to stannous ion being in the range of from 3.5:1 to 5.7:1 in the aqueous condition, the molar ratio of the acid selected from the group consisting of a dicarboxylic acid, a tricarboxylic acid and a mineral acid to stannous ion being in the range of from 0.2×0.6 n :1 to 5×0.6 n :1, the exponent "n" being the weight percent content of the stannous ion in the composition, and said orally acceptable acid being present in the composition in such an amount that the pH of the composition is in the range of from 2 to 4.
Claim 5
Dependent Claim
37 words
The oral composition according to claim 1 or 2, wherein said stannous salt is at least one member selected from the group consisting of stannous fluoride, stannous chloride, stannous chlorofluoride, stannous pyrophosphate, stannous monofluorophosphate and stannous acetate.
Claim 6
Dependent Claim
16 words
The oral composition according to claim 1 or 2, wherein said stannous salt is stannous fluoride.
Claim 7
Dependent Claim
33 words
The oral composition according to claim 1, wherein said monocarboxylic acid is selected from the group consisting of L-ascorbic acid, lactic acid, acetic acid, propionic acid, n-butyric acid, gluconic acid and mixtures thereof.
Claim 8
Dependent Claim
37 words
The oral composition according to claim 2, wherein said dicarboxylic acid is selected from the group consisting of malonic acid, tartaric acid, malic acid, succinic acid, maleic acid, L-aspartic acid, L-glutamic acid, oxalic acid and mixtures thereof.
Claim 9
Dependent Claim
14 words
The oral composition according to claim 2, wherein said tricarboxylic acid is citric acid.
Claim 10
Dependent Claim
29 words
The oral composition according to claim 2, wherein said mineral acid is selected from the group consisting of hydrochloric acid, sulfuric acid, orthophosphoric acid, pyrophosphoric acid and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-13 | 1986-06-14 | 1986-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-13 | 1990-06-14 | 1990-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-13 | 1994-06-14 | 1994-12-14 | $7700.00 | Window Closed / Lapsed |