US4361574A
Expired / Lapsed
US
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Inhibitors of mammalian collagenase
Assignee: Wyeth LLC
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Filing: 1981-10-02
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Granted: 1982-11-30
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Expires: 2001-10-02
Abstract
Abstract A method of inhibiting mammalian collagenase by using 3-(p-substituted phenyl)-thiazolo[3,2-a]benzimidazole-2-alkanoic acids and esters thereof, and the pharmaceutically acceptable salts thereof.
Inventors
- 👤 Norman H. Grant
- 👤 Donald E. Clark
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:04
CPC Classifications
C; C07; C07D; C07D513/00; C07D513/02; C07D513/04
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
75 words
A method of inhibiting mammalian collagenase in mammals afflicted with a disease state in which collagen is broken down by collagenase, which comprises administering to such an afflicted mammal an amount sufficient to reverse said collagenase-induced collagen break down of a collagenase inhibitor having the formula: ##STR3## wherein R is hydrogen or lower alkyl and R 1 is lower alkyl, lower alkoxy, trifluoromethyl or halo, n is 1 or 2 and pharmaceutically acceptable salts thereof.
Claim 2
Independent Claim
75 words
A method of inhibiting mammalian collagenase in mammals afflicted with a disease state in which collagen is broken down by collagenase, which comprises administering to such an afflicted mammal an amount sufficient to reverse said collagenase-induced collagen break down of a collagenase inhibitor having the formula: ##STR3## wherein R is hydrogen or lower alkyl and R 1 is lower alkyl, lower alkoxy, trifluoromethyl or halo, n is 1 or 2 and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
17 words
The method of claim 1 wherein R is hydrogen, R 1 is chloro and n is 1.
Claim 4
Dependent Claim
17 words
The method of claim 1, wherein R is hydrogen, R 1 is fluoro and n is 1.
Claim 5
Dependent Claim
17 words
The method of claim 1, wherein R is hydrogen, R 1 is bromo and n is 1.
Claim 6
Dependent Claim
17 words
The method of claim 1, wherein R is hydrogen, R 1 is methyl and n is 1.
Claim 7
Dependent Claim
17 words
The method of claim 1, wherein R is hydrogen, R 1 is methoxy and n is 1.
Claim 8
Dependent Claim
17 words
The method of claim 1, wherein R is hydrogen, R 1 is trifluoromethyl and n is 1.
References Cited (Backward Citations)
US4214089A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |