US4361553A
Expired / Lapsed
US
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Therapeutic uses of dynorphin
Assignee: Neurobiological Technologies Inc
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Filing: 1981-05-18
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Granted: 1982-11-30
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Expires: 2001-05-18
Abstract
Abstract A therapeutic method of using dynorphin comprises administering dynorphin to a host tolerant to narcotic analgesics. Practice of the therapeutic method provides that lower doses of a narcotic analgesic may be used, such as for patients requiring chronic treatment with narcotics to ease pain, and for treatment of narcotics addicts.
Inventors
- 👤 Horace H. Loh
- 👤 Nancy M. Lee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:57
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
47 words
A therapeutic method of using dynorphin comprising: administering a dynorphin dose, said dynorphin dose including a polypeptide having at least the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO, the TYR-GLY-GLY-PHE-LEU portion of said sequence defining an N-terminal end for said polypeptide, the administering being to a host tolerant to a narcotic analgesic.
Claim 2
Dependent Claim
47 words
A therapeutic method of using dynorphin comprising: administering a dynorphin dose, said dynorphin dose including a polypeptide having at least the sequence TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO, the TYR-GLY-GLY-PHE-LEU portion of said sequence defining an N-terminal end for said polypeptide, the administering being to a host tolerant to a narcotic analgesic.
Claim 3
Dependent Claim
27 words
The therapeutic method as in claim 1 wherein: the administering is in conjunction with administering a dose of the narcotic analgesic to which the host is tolerant.
Claim 4
Dependent Claim
31 words
The therapeutic method as in claim 2 wherein: the administering of said dynorphin dose is within at least about 30 minutes of the administering of said dose of the narcotic analgesic.
Claim 5
Dependent Claim
21 words
The therapeutic method as in claim 2 wherein: said dynorphin dose and said dose of the narcotic analgesic are simultaneously administered.
Claim 6
Dependent Claim
16 words
The therapeutic method as in claim 1 wherein: the dynorphin in said dynorphin dose includes dynorphin-(1-13).
Claim 7
Dependent Claim
17 words
The therapeutic method as in claim 2 wherein: said dose of narcotic analgesic includes an opiate alkaloid.
Claim 8
Dependent Claim
22 words
The therapeutic method as in claim 1 or 2 wherein: the narcotic analgesic is morphine, a morphine analog, or a morphine salt.
Claim 9
Dependent Claim
14 words
The therapeutic method as in claim 1 wherein: said dynorphin dose is administered intraveneously.
Claim 10
Dependent Claim
25 words
The therapeutic method as in claim 1 wherein: said dynorphin dose of the administering is sufficient to retard withdrawal syndrome from occurring in the host.
Claim 11
Dependent Claim
102 words
A therapeutic method of producing analgesia in a host tolerant to a narcotic analgesic comprising the steps of: determining a first dose of said narcotic analgesic, said first dose being sufficient to produce an analgesic level in the host; administering a predetermined dose of said narcotic analgesic to the host, said second host being lower than said first dose of the determining step; and, supplementing said second dose with a third dose, said third dose including dynorphin-(1-13), the supplementing being sufficient to produce a level of analgesia in the host which is substantially equivalent to the analgesic level of the determining step.
Claim 12
Dependent Claim
102 words
A therapeutic method of producing analgesia in a host tolerant to a narcotic analgesic comprising the steps of: determining a first dose of said narcotic analgesic, said first dose being sufficient to produce an analgesic level in the host; administering a predetermined dose of said narcotic analgesic to the host, said second host being lower than said first dose of the determining step; and, supplementing said second dose with a third dose, said third dose including dynorphin-(1-13), the supplementing being sufficient to produce a level of analgesia in the host which is substantially equivalent to the analgesic level of the determining step.
Claim 13
Dependent Claim
22 words
The therapeutic method as in claim 10 wherein: the supplementing step is within at least about 30 minutes of the administering step.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-29 | 1986-05-31 | 1986-11-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-29 | 1990-05-31 | 1990-11-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-29 | 1994-05-31 | 1994-11-30 | $7700.00 | Window Closed / Lapsed |