US4360685A
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Dioxatricyclic prostacyclin analogs
Assignee: ER Squibb and Sons LLC
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Filing: 1981-09-25
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Granted: 1982-11-23
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Expires: 2001-09-25
Abstract
Abstract New dioxatricyclic prostacyclin analogs are provided which have the general formula ##STR1## wherein R is hydrogen or lower alkyl, Q is a single bond or --CH 2 --, m is 1 to 9 and n is 3 or 4, and all stereoisomers thereof, and are useful as cardiovascular agents.
Inventors
- 👤 Martin F. Haslanger
- 👤 Peter W. Sprague
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 17:31
CPC Classifications
C; C07; C07D; C07D493/00; C07D493/02; C07D493/08; A; A61; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
39 words
A compound having the structural formula ##STR20## and including all stereoisomers thereof, wherein R is hydrogen or lower alkyl, Q is a single bond or --CH 2 --, m is 1 to 9, and n is 3 or 4.
Claim 2
Dependent Claim
39 words
A compound having the structural formula ##STR20## and including all stereoisomers thereof, wherein R is hydrogen or lower alkyl, Q is a single bond or --CH 2 --, m is 1 to 9, and n is 3 or 4.
Claim 3
Dependent Claim
14 words
The compound of claim 1 having the structure ##STR21## and including all stereoisomers thereof.
Claim 4
Dependent Claim
14 words
The compound of claim 1 having the structure ##STR22## and including all stereoisomers thereof.
Claim 5
Dependent Claim
27 words
The compound of claim 1 wherein R is hydrogen and m is 4 so that (CH 2 ) m CH 3 represents C 5 H 11 .
Claim 6
Dependent Claim
9 words
The compound of claim 2 having the structure ##STR23##
Claim 7
Dependent Claim
22 words
The compound of claim 5 wherein R is H and --(CH 2 ) m CH 3 is --C 5 H 11 .
Claim 8
Dependent Claim
18 words
The compound of claim 6 wherein n is 3 and having the name [2α,3aα,5Z,7α,7aα,8S*(1E,3R)]-5-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-5H-furo[3,2-b]pyran-5-ylidene]pentanoic acid or [2α,3aα,5α(E),7α,7aα,8S*(1E,3R)]-5-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-2H-furo[3,2-b]pyran-5-yl]-4-pentenoic acid.
Claim 9
Dependent Claim
18 words
The compound of claim 6 wherein n is 4 and having the name [2α,3aα,6Z,7α,7aα,8S*(1E,3R)]-6-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-5H-furo[3,2-b]pyran-6-ylidine]hexanoic acid or [2α,3aα,5α(E),7α,7aα,8S*(1E,3R)]-6-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-2H-furo[3,2-b]pyran-6-yl]-5-hexenoic acid.
Claim 10
Dependent Claim
9 words
The compound of claim 2 having the structure ##STR24##
Claim 11
Dependent Claim
21 words
The compound of claim 9 wherein R is H and --(CH 2 ) m CH is --C 5 H 11 .
Claim 12
Dependent Claim
18 words
The compound of claim 10 wherein n is 3 and having the name [2α,3aα,5Z,7α,7aα,8S*(1E,3S)]-5-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-5H-furo[3,2-b]pyran-5-ylidene]pentanoic acid or [2α,3aα,5α(E),7α,7aα,8S*(1E,3S)]-5-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-2H-furo[3,2-b]-pyran-5-yl]-4-pentenoic acid.
Claim 13
Dependent Claim
18 words
The compound of claim 10 wherein n is 4 and having the name [2α,3aα,6Z,7α,7aα,8S*(1E,3S)]-6-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-5H-furo[3,2-]pyran-6-ylidine]hexanoic acid or [2α,3aα,5α(E),7α,7aα,8S*(1E,3S)]-6-[hexahydro-8-(3-hydroxy-1-octenyl)-2,7-methano-2H-furo-[3,2-b]pyran-6-yl]-5-hexenoic acid.
Claim 14
Dependent Claim
9 words
The compound of claim 3 having the structure ##STR25##
Claim 15
Dependent Claim
22 words
The compound of claim 13 wherein R is H and --(CH 2 ) m CH 3 is C 5 H 11 .
Claim 16
Dependent Claim
18 words
The compound of claim 14 wherein n is 3 and having the name [2α,3aα,6Z,6α,6aα,7S*(1E,3R)]-6-[tetrahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]furan-5(2H)-ylidene]hexanoic acid or [2α,3aα,5α(E),6α,6aα,7S*(1E,3R)]-6-[hexahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]-furan-5-yl]-5-hexanoic acid.
Claim 17
Dependent Claim
18 words
The compound of claim 14 wherein n is 4 and having the name [2α,3aα,5Z,6α,6aα,7S*(1E,3R)]-5-[tetrahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]furan-5(2H)-ylidene]pentanoic acid or [2α,3aα,5α(E),6α,6aα,7S*(1E,3R)]-5-[hexahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]-furan-5-yl]-4-pentenoic acid.
Claim 18
Dependent Claim
9 words
The compound of claim 13 having the structure ##STR26##
Claim 19
Dependent Claim
22 words
The compound of claim 17 wherein R is H and --(CH 2 ) m CH 3 is --C 5 H 11 .
Claim 20
Dependent Claim
18 words
The compound of claim 18 wherein n is 3 and having the name [2α,3aα,5Z,6α,6aα,7S*(1E,3S)]-5-[tetrahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]furan-5(2H)-ylidine]pentanoic acid or [2α,3aα,5α(E),6α,7aα,7S*(1E,3S)]-5-[hexahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]furan-5-yl]-4-pentenoic acid.
Claim 21
Dependent Claim
18 words
The compound of claim 18 wherein n is 4 and having the name [2α,3aα,6Z,6α,6aα,7S*(1E,3S)]-6-[tetrahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]furan-5(2H)-ylidene]hexanoic acid or [2α,3aα,5α(E),6α,6aα,7S*(1E,3S)]-6-[hexahydro-7-(3-hydroxy-1-octenyl)-2,6-methano-furo[3,2-b]-furan-5-yl]-5-hexenoic acid.
Claim 22
Dependent Claim
10 words
The compound of claim 1 wherein R is lower alkyl.
Claim 23
Dependent Claim
23 words
The compound of claim 21 wherein R is CH 3 and (CH 2 ) m CH 3 is C 5 H 11 .
Claim 24
Dependent Claim
23 words
The compound of claim 2 wherein R is CH 3 and (CH 2 ) m CH 3 is C 5 H 11 .
Claim 25
Dependent Claim
23 words
The compound of claim 3 wherein R is CH 3 and (CH 2 ) m CH 3 is C 5 H 11 .
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-22 | 1986-05-24 | 1986-11-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-22 | 1990-05-24 | 1990-11-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-22 | 1994-05-24 | 1994-11-23 | $7700.00 | Window Closed / Lapsed |