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US4359454A Expired / Lapsed US ⏱️ 0.0 years remaining

Method and composition containing MCA for female sterilization

Assignee: WORLD HEALTH ORGANIZATION 1211 GENEVE 27 SWITZERLAND
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Filing: 1980-12-16
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Granted: 1982-11-16
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Expires: 2000-12-16
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Abstract

Abstract A method of female sterilization which comprises instilling methyl cyanoacrylate and radiopaque additive in the oviduct, allowing the methyl cyanoacrylate (MCA) to polymerize and induce an inflammatory response on the inside lining of the oviduct such that dense fibrous scar tissue is deposited across the oviduct lumen and the oviduct is occluded by natural scar tissue. The radiopaque additive permits the instillation to be examined by X-ray to insure proper positioning of the formulation and resultant blockage of the oviduct. The polymerized methyl cyanoacrylate degrades and is readily cleared along with other components of the formulation from the oviduct. In one embodiment the MCA and radiopaque additive are instilled together in liquid water-free form although they may also be instilled separately. The latter embodiment permits the use of aqueous systems for the radiopaque material. Acid and free radical polymerization inhibitors should also be used to prevent premature polymerization. Isobutyl cyanoacrylate may also be used with the MCA.

Inventors

  • 👤 Allan S. Hoffman

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 16:25
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0039; A61K49/00; A61K49/04; A61K49/0433; A61K49/0447

Claims Analysis

Total Claims: 9
Claim 1
Independent Claim 85 words
In a method of female sterilization which comprises instilling liquid water-free methyl cyanoacrylate in the oviduct whereby the methyl cyanoacrylate polymerizes and degrades to induce an inflammatory response on the lining of the oviduct such that dense fibrous tissue is deposited across the oviduct lumen and the oviduct is thereby occluded by natural scar tissue, the improvement which comprises using the methyl cyanoacrylate polymer with ethyl-10-(iodophenyl) undecanoate so that the positioning of the methyl cyanoacrylate instilled in the oviduct can be determined by X-ray eximination.
Claim 2
Dependent Claim 85 words
In a method of female sterilization which comprises instilling liquid water-free methyl cyanoacrylate in the oviduct whereby the methyl cyanoacrylate polymerizes and degrades to induce an inflammatory response on the lining of the oviduct such that dense fibrous tissue is deposited across the oviduct lumen and the oviduct is thereby occluded by natural scar tissue, the improvement which comprises using the methyl cyanoacrylate polymer with ethyl-10-(iodophenyl) undecanoate so that the positioning of the methyl cyanoacrylate instilled in the oviduct can be determined by X-ray eximination.
Claim 3
Dependent Claim 18 words
The method of claim 1 wherein the formulation includes up to 20% by volume of another faster-curing cyanoacrylate.
Claim 4
Dependent Claim 12 words
The method of claim 2 wherein the other cyanoacrylate is isobutyl cyanoacrylate.
Claim 5
Dependent Claim 26 words
The method of claim 1 wherein the formulation includes an acid and a free radical polymerization inhibitor present in an amount sufficient to prevent premature polymerization.
Claim 6
Dependent Claim 72 words
A liquid, water-free formulation for use in female sterilization which consists essentially of methyl cyanoacrylate; 10-50% ethyl-10-(iodophenyl) undecanoate based on the volume of the formulation from 0.01 to 3% by volume of an acid polymerization inhibitor, based on the methyl cyanoacrylate content, and from 0.01 to 1% by weight of a free radical polymerization inhibitor, based on the weight of methylcyanoacrylate, the inhibitors being present in amounts sufficient to prevent premature polymerization.
Claim 7
Dependent Claim 72 words
A liquid, water-free formulation for use in female sterilization which consists essentially of methyl cyanoacrylate; 10-50% ethyl-10-(iodophenyl) undecanoate based on the volume of the formulation from 0.01 to 3% by volume of an acid polymerization inhibitor, based on the methyl cyanoacrylate content, and from 0.01 to 1% by weight of a free radical polymerization inhibitor, based on the weight of methylcyanoacrylate, the inhibitors being present in amounts sufficient to prevent premature polymerization.
Claim 8
Dependent Claim 19 words
A formulation according to claim 5 wherein the formulation weighs up to 20% by volume of another faster-curing cyanoacrylate.
Claim 9
Dependent Claim 13 words
A formulation according to claim 6 wherein the other cyanoacrylate is isobutyl cyanoacrylate.

References Cited (Backward Citations)

US3360124A Cited
US3896077A Cited
US4086266A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-11-15 1986-05-17 1986-11-16 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-11-15 1990-05-17 1990-11-16 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-11-15 1994-05-17 1994-11-16 $7700.00 Window Closed / Lapsed

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