US4357343A
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Nutritional composition for management of renal failure
Assignee: Baxter International Inc
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Filing: 1981-06-26
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Granted: 1982-11-02
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Expires: 2001-06-26
Abstract
Abstract A novel amino acid composition is provided for the nutritional maintenance of renal failure patients.
Inventors
- 👤 David C. Madsen
- 👤 Hugh N. Tucker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 08:32
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/01
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
95 words
A composition for treating renal failure or deficiency, comprising an amino acid mixture consisting of the following amino acids in the stated proportions: ______________________________________
Mole Percent Range
Amino Acid about from
______________________________________
L-Leucine 8.6 to 8.9
L-Phenylalanine
5.6 to 5.8
L-Methionine 7.2 to 6.5
L-Lysine (free base)
5.8 to 6.0
L-Isoleucine 7.2 to 7.5
L-Valine 12.1 to 13.6
L-Histidine 5.2 to 6.9
L-Threonine 5.9 to 6.3
L-Tryptophan 1.4 to 1.5
L-Alanine 11.7 to 12.4
Glycine 7.7 to 8.9
L-Arginine 5.6 to 7.0
L-Proline 5.9 to 6.2
L-Tyrosine 0.3 to 0.6
L-Serine 5.5 to 6.3
______________________________________
Claim 2
Dependent Claim
95 words
A composition for treating renal failure or deficiency, comprising an amino acid mixture consisting of the following amino acids in the stated proportions: ______________________________________
Mole Percent Range
Amino Acid about from
______________________________________
L-Leucine 8.6 to 8.9
L-Phenylalanine
5.6 to 5.8
L-Methionine 7.2 to 6.5
L-Lysine (free base)
5.8 to 6.0
L-Isoleucine 7.2 to 7.5
L-Valine 12.1 to 13.6
L-Histidine 5.2 to 6.9
L-Threonine 5.9 to 6.3
L-Tryptophan 1.4 to 1.5
L-Alanine 11.7 to 12.4
Glycine 7.7 to 8.9
L-Arginine 5.6 to 7.0
L-Proline 5.9 to 6.2
L-Tyrosine 0.3 to 0.6
L-Serine 5.5 to 6.3
______________________________________
Claim 3
Dependent Claim
59 words
The composition of claim 1 wherein the mole percentages of L-leucine, L-phenylalanine, L-methionine, L-lysine, L-isoleucine, L-valine, L-histidine, L-threonine, L-tryptophan, L-alanine, glycine L-arginine, L-proline, L-tyrosine, and L-serine are, respectively, about 8.6, about 5.7, about 7.2, about 5.8, about 7.2, about 12.1, about 6.9, about 5.9, about 1.5, about 11.7, about 8.9, about 5.6, about 6.1, about 0.5 and about 6.3.
Claim 4
Dependent Claim
16 words
The composition of claim 2 further comprising water soluble vitamins and digestively assimilable carbohydrates and fats.
Claim 5
Dependent Claim
21 words
The composition of claim 2 in aqueous solution in a concentration of about from 1 to 10 grams of amino acid/dl.
Claim 6
Dependent Claim
14 words
The composition of claim 2 which is essentially free of electrolytes and fat-soluble vitamins.
Claim 7
Independent Claim
23 words
A method for treating a renal failure patient, comprising orally administering the composition of claims 2, 3, 4 or 5 to said patient.
Claim 8
Dependent Claim
59 words
The composition of claim 1 wherein the mole percentages of L-leucine, L-phenylalanine, L-methionine, L-lysine, L-isoleucine, L-valine, L-histidine, L-threonine, L-tryptophan, L-alanine, glycine L-arginine, L-proline, L-tyrosine, and L-serine are, respectively, about 8.9, about 5.6, about 7.4, about 6.0, about 7.5, about 12.4, about 5.2, about 6.3, about 1.4, about 12.4, about 7.7, about 7.0, about 6.1, about 0.5 and about 5.5.
Claim 9
Dependent Claim
23 words
The composition of claim 7 as a sterile aqueous solution at a concentration of about from 3 to 10 grams of amino acid/dl.
Claim 10
Dependent Claim
11 words
The composition of claim 7 which is essentially free of electrolytes.
Claim 11
Dependent Claim
11 words
The composition of claim 8 wherein the pH is about 6.0.
Claim 12
Dependent Claim
23 words
A method for treating a renal failure patient, comprising parenteral administration of the composition of claim 8, 9 or 10 to said patient.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-01 | 1986-05-03 | 1986-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-01 | 1990-05-03 | 1990-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-01 | 1994-05-03 | 1994-11-02 | $7700.00 | Window Closed / Lapsed |