US4357326A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Multi-glucopyranosyl-fructofuranosyl-galactopyranosyl-glucopyranoside sulfate salts and methods of use
Assignee: Wyeth Holdings LLC
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Filing: 1981-08-28
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Granted: 1982-11-02
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Expires: 2001-08-28
Abstract
Abstract O-α-D-glucopyranosyl(1→4)-[O-α-D-glucopyranosyl-(1.fwdarw.4)] n -O-β-D-glucopyranosyl(1→6)-β-D-fructofuranosyl-O-α-D-galactopyranosyl(1→6)-α-D-glucopyranoside sulfate salts, useful as inhibitors of the complement system and the process of making such compounds.
Inventors
- 👤 Vijay G. Nair
- 👤 Joseph P. Joseph
- 👤 Seymour Bernstein
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 06:22
CPC Classifications
C; C07; C07H; C07H3/00; C07H3/06
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
80 words
A compound selected from those of the formula: ##STR27## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 2
Dependent Claim
80 words
A compound selected from those of the formula: ##STR27## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 3
Dependent Claim
7 words
The compound according to claim 1, ##STR28##
Claim 4
Dependent Claim
7 words
The compound according to claim 1, ##STR29##
Claim 5
Dependent Claim
7 words
The compound according to claim 1, ##STR30##
Claim 6
Dependent Claim
7 words
The compound according to claim 1, ##STR31##
Claim 7
Independent Claim
109 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a pharmaceutically acceptable compound selected from those of the formula: ##STR32## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 8
Independent Claim
109 words
A method of inhibiting the complement system in a body fluid which comprises subjecting said body fluid to the action of an effective complement inhibiting amount of a pharmaceutically acceptable compound selected from those of the formula: ##STR32## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 9
Independent Claim
105 words
A method of inhibiting the complement system in warm-blooded animal which comprises administering to said warm-blooded animal an effective complement inhibiting amount of a pharmaceutically acceptable compound selected from those of the formula: ##STR33## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 10
Independent Claim
105 words
A method of inhibiting the complement system in warm-blooded animal which comprises administering to said warm-blooded animal an effective complement inhibiting amount of a pharmaceutically acceptable compound selected from those of the formula: ##STR33## wherein n is an integer from zero to five, inclusive; X is --SO 3 A; and A is a pharmaceutically acceptable cation salt, wherein the salt forming moiety is selected from the group consisting of alkali metal, alkaline earth metal, ammonia and substituted ammonia selected from the group consisting of trialkylamine (C 1 -C 6 ), piperidine, pyrazine, alkanolamine (C 2 -C 6 ) and cycloalkylamine (C 3 -C 6 ).
Claim 11
Dependent Claim
13 words
The method according to claim 6 or 7, wherein the compound is ##STR34##
Claim 12
Dependent Claim
13 words
The method according to claim 6 or 7, wherein the compound is ##STR35##
Claim 13
Dependent Claim
13 words
The method according to claim 6 or 7, wherein the compound is ##STR36##
Claim 14
Dependent Claim
13 words
The method according to claim 6 or 7, wherein the compound is ##STR37##
Claim 15
Dependent Claim
12 words
The method according to claim 7, wherein the compound is administered internally.
Claim 16
Dependent Claim
12 words
The method according to claim 7, wherein the compound is administered topically.
Claim 17
Dependent Claim
16 words
The method according to claim 7, wherein the compound is administered periodontally in the oral cavity.
Claim 18
Dependent Claim
12 words
The method according to claim 7, wherein the compound is administered intra-articularly.
Claim 19
Dependent Claim
12 words
The method according to claim 7, wherein the compound is administered parenterally.
References Cited (Backward Citations)
US4098995A
Cited
US4221907A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-01 | 1986-05-03 | 1986-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-01 | 1990-05-03 | 1990-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-01 | 1994-05-03 | 1994-11-02 | $7700.00 | Window Closed / Lapsed |