US4357321A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method and composition for treating clotting factor inhibitors
Assignee: Baxter International Inc
•
Filing: 1981-05-11
•
Granted: 1982-11-02
•
Expires: 2001-05-11
Abstract
Abstract A composition comprising about from 37 to 190 units of factor VII/ml and about from 25 to 80 units of factor VIIa/ml is administered to patients in the treatment of clotting factor inhibitors. The composition may include activated and unactivated clotting factors such as factors IX, IXa, Xa and X.
Inventors
- 👤 William R. Thomas
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 22:58
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/647; C12N9/6429; C12Y; C12Y304/00; C12Y304/21; C12Y304/21005; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
46 words
A method for treating a patient having an inhibitor of a blood clotting factor, which comprises administering to the patient a therapeutically effective dose of an aqueous composition comprising about from 37 to 110 units of F-VII-ml and about from 8 to 80 units of V-Vlla/ml.
Claim 2
Independent Claim
46 words
A method for treating a patient having an inhibitor of a blood clotting factor, which comprises administering to the patient a therapeutically effective dose of an aqueous composition comprising about from 37 to 110 units of F-VII-ml and about from 8 to 80 units of V-Vlla/ml.
Claim 3
Dependent Claim
22 words
The method of claim 1 wherein the therapeutically effective dose is greater than about 25 factor VIII correctional units/kg of patient weight.
Claim 4
Dependent Claim
17 words
The method of claim 1 wherein the aqueous composition additionally comprises greater than 1.1 units of heparin/ml.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein the aqueous composition additionally comprises antithrombin lll.
Claim 6
Dependent Claim
28 words
The method of claim 1 wherein the aqueous composition is sufficiently free of factor Vlll antigen to not provoke an immune response in the patient to factor Vlll.
Claim 7
Dependent Claim
27 words
An aqueous composition for treating clotting factor inhibitors which comprises about from 37 to 190 units of F-VII/ml and about from 25 to 80 units of F-VIIa/ml.
Claim 8
Dependent Claim
27 words
An aqueous composition for treating clotting factor inhibitors which comprises about from 37 to 190 units of F-VII/ml and about from 25 to 80 units of F-VIIa/ml.
Claim 9
Dependent Claim
14 words
The aqueous composition of claim 6, additionally comprising greater than 1.1 units of heparin/ml.
Claim 10
Dependent Claim
9 words
The composition of claim 7 additionally comprising antithrombin III.
Claim 11
Dependent Claim
24 words
The composition of claim 6 which is sufficiently free of factor VIII antigen to not provoke an immune response to factor VIII in humans.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-11-01 | 1986-05-03 | 1986-11-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-11-01 | 1990-05-03 | 1990-11-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-11-01 | 1994-05-03 | 1994-11-02 | $7700.00 | Window Closed / Lapsed |