US4356184A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
Assignee: GD Searle LLC
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Filing: 1981-03-25
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Granted: 1982-10-26
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Expires: 2001-03-25
Abstract
Abstract 1-Piperidinylmethyl benzenamines represented by the formula: ##STR1## wherein X is S or --CH 2 --CH 2 --; R 1 and R 2 are the same different members of the group consisting of hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof. The compounds are useful as anti-allergic and antihypertensive agents.
Inventors
- 👤 James R. Deason
- 👤 Richard A. Partis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:16
CPC Classifications
C; C07; C07D; C07D409/00; C07D409/02; C07D409/04; C07D211/00; C07D211/04; C07D211/68; C07D211/70
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
45 words
A 1-piperidinylmethyl benzenamine represented by the formula: ##STR6## wherein: X is --S-- or --CH 2 --CH 2 --; and R 1 and R 2 are the same or different members of the group consisting of hydrogen or loweralkyl; or a the pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
45 words
A 1-piperidinylmethyl benzenamine represented by the formula: ##STR6## wherein: X is --S-- or --CH 2 --CH 2 --; and R 1 and R 2 are the same or different members of the group consisting of hydrogen or loweralkyl; or a the pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
30 words
A compound of claim 1 wherein X is --S-- and the compound is represented by the Formula: ##STR7## wherein R 1 and R 2 are as defined in claim 1.
Claim 4
Dependent Claim
12 words
A compound of claim 2; N,N-dimethyl-4-[4-(9H-thioxanthene-9-ylidene)-1-piperidinylmethyl]-benzenamine or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
34 words
A compound of claim 1 wherein X is --CH 2 --CH 2 -- and the compound is represented by the formula ##STR8## wherein R 1 and R 2 are as defined in claim 1.
Claim 6
Dependent Claim
12 words
A compound of claim 4: N,N-dimethyl-4-[4-(5H-dibenzo[a,d]cycloheptan-5-ylidene)-1-piperidinylmethyl]benzenamine or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
24 words
An anti-allergic or antihypertensive pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier or diluent.
Claim 8
Dependent Claim
17 words
A pharmaceutical composition of claim 6 wherein said compound is N,N-dimethyl-4-[4-(9H-thioxanthene-9-ylidine)-1-piperidinylmethyl]-benzenamine or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
17 words
A pharmaceutical composition of claim 6 wherein said compound is N,N-dimethyl-4-[4-(5H-dibenzo[a,d]cycloheptan-5-ylidene-1-piperidinylmethyl]benzenamine or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
CA746508A
Cited
US3014911A
Cited
GB1103718A
Cited
FR1516783A
Cited
DE2256392A1
Cited
US3862156A
Cited
US4275209A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-25 | 1986-04-26 | 1986-10-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-25 | 1990-04-26 | 1990-10-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-25 | 1994-04-26 | 1994-10-26 | $7700.00 | Window Closed / Lapsed |